Gastrin Significantly Modifies the Migratory Abilities of Experimental Glioma Cells

Malignant astrocytic tumors are characterized by the pronounced and diffuse migration of tumor astrocytes into the brain parenchyma. The present study shows that gastrin is a brain neuropeptide that is able to significantly modulate astrocytic tumor migration at both invasion and motility levels. In...

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Veröffentlicht in:	Laboratory investigation 2002-09, Vol.82 (9), p.1241-1252
Hauptverfasser:	Lefranc, Florence, Camby, Isabelle, Belot, Nathalie, Bruyneel, Erik, Chaboteaux, Carole, Brotchi, Jacques, Mareel, Marcus, Salmon, Isabelle, Kiss, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Movement - drug effects Cytoskeleton - drug effects Gastrins - genetics Gastrins - pharmacology General aspects (metabolism, cell proliferation, established cell line...) Glioma - chemistry Glioma - mortality Glioma - pathology Humans Laboratory Medicine Medical sciences Medicine Medicine & Public Health Neoplasm Transplantation Pathology Rats Rats, Wistar Receptor, Cholecystokinin A Receptor, Cholecystokinin B Receptors, Cholecystokinin - analysis rhoA GTP-Binding Protein - analysis RNA, Messenger - analysis Tumor cell Tumor Cells, Cultured Tumors
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