Cocaine treatment in neonatal rats affects the adult behavioral response to amphetamine
This study investigated whether exposure to cocaine during critical periods of brain development alters the motor stimulating effects of amphetamine given in adulthood. Female rats received 50 mg/kg/day cocaine HCl SC or vehicle during either postnatal days 1–10 or 11–20. At 60–65 days of age, activ...
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| Veröffentlicht in: | Neurotoxicology and teratology 1991-05, Vol.13 (3), p.335-339 |
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| container_title | Neurotoxicology and teratology |
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| creator | Hughes, Harry E. Pringle, Graham F. Scribani, Louis A. Dow-Edwards, Diana L. |
| description | This study investigated whether exposure to cocaine during critical periods of brain development alters the motor stimulating effects of amphetamine given in adulthood. Female rats received 50 mg/kg/day cocaine HCl SC or vehicle during either postnatal days 1–10 or 11–20. At 60–65 days of age, activity counts were collected over a 15-min baseline period. Subjects then received one of 3 doses (0, 0.1, 0.25 mg/kg) of d-amphetamine sulfate SC followed by a 90-min period of activity monitoring. Adult activity in 1–10-day cocaine-treated rats was different from vehicle-treated rats in response to 0.1 mg/kg amphetamine only. Adult activity in 11–20-day cocaine-treated rats was different from vehicle-treated rats in response to 0.25 mg/kg only. The observed differences represented an increase and decrease in activity, respectively. These alterations in amphetamine response may be related to the observed alterations in D-1 receptor concentrations as well as the altered rates of brain glucose metabolism we have observed in adult rats neonatally exposed to cocaine. |
| doi_str_mv | 10.1016/0892-0362(91)90080-G |
| format | Article |
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Female rats received 50 mg/kg/day cocaine HCl SC or vehicle during either postnatal days 1–10 or 11–20. At 60–65 days of age, activity counts were collected over a 15-min baseline period. Subjects then received one of 3 doses (0, 0.1, 0.25 mg/kg) of d-amphetamine sulfate SC followed by a 90-min period of activity monitoring. Adult activity in 1–10-day cocaine-treated rats was different from vehicle-treated rats in response to 0.1 mg/kg amphetamine only. Adult activity in 11–20-day cocaine-treated rats was different from vehicle-treated rats in response to 0.25 mg/kg only. The observed differences represented an increase and decrease in activity, respectively. These alterations in amphetamine response may be related to the observed alterations in D-1 receptor concentrations as well as the altered rates of brain glucose metabolism we have observed in adult rats neonatally exposed to cocaine.</description><subject>Amphetamine</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Cocaine</subject><subject>Cocaine - pharmacology</subject><subject>Development</subject><subject>Dextroamphetamine - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug addictions</subject><subject>Female</subject><subject>Locomotor activity</subject><subject>Medical sciences</subject><subject>Motor Activity - drug effects</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reference Values</subject><subject>Toxicology</subject><issn>0892-0362</issn><issn>1872-9738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vEzEQhi0EakPhHxRpL1RwWBivvf64VKoiCEiVuLTiaM16ZxWj_UhtpxL_HodE7Q1Oc5jnfTV-zNglh08cuPoMxjY1CNV8sPyjBTBQb16wFTe6qa0W5iVbPSHn7HVKvwBAKw5n7Iwbo1opV-znevEYZqpyJMwTzbkKczXTMmPGsYqYU4XDQL7MvKUK-_2Yq462-BiWeCAo7ZY5lYKlwmm3pYxT6XvDXg04Jnp7mhfs_uuXu_W3-vbH5vv65rb2kptcqwG0FV3boBSdsuXcdlBGNqSF7Um0stPSqnJz37XcUyeHErMdFMz0vdLigl0de3dxedhTym4KydM4YnnDPjndgDZcwH9BroCLRpkCyiPo45JSpMHtYpgw_nYc3EG8O1h1B6vOcvdXvNuU2LtT_76bqH8OHU2X_fvTHpPHcYg4-5CeMautEVYV7vrIUbH2GCi65APNnvoQyy-4fgn_PuQPPOSelA</recordid><startdate>19910501</startdate><enddate>19910501</enddate><creator>Hughes, Harry E.</creator><creator>Pringle, Graham F.</creator><creator>Scribani, Louis A.</creator><creator>Dow-Edwards, Diana L.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7T2</scope><scope>7TK</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19910501</creationdate><title>Cocaine treatment in neonatal rats affects the adult behavioral response to amphetamine</title><author>Hughes, Harry E. ; Pringle, Graham F. ; Scribani, Louis A. ; Dow-Edwards, Diana L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-6f0793b52a43b698925f6842e739de354b7496610db51ceb4f4189b025f8dd673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Amphetamine</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Cocaine</topic><topic>Cocaine - pharmacology</topic><topic>Development</topic><topic>Dextroamphetamine - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug addictions</topic><topic>Female</topic><topic>Locomotor activity</topic><topic>Medical sciences</topic><topic>Motor Activity - drug effects</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reference Values</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hughes, Harry E.</creatorcontrib><creatorcontrib>Pringle, Graham F.</creatorcontrib><creatorcontrib>Scribani, Louis A.</creatorcontrib><creatorcontrib>Dow-Edwards, Diana L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Neurotoxicology and teratology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hughes, Harry E.</au><au>Pringle, Graham F.</au><au>Scribani, Louis A.</au><au>Dow-Edwards, Diana L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cocaine treatment in neonatal rats affects the adult behavioral response to amphetamine</atitle><jtitle>Neurotoxicology and teratology</jtitle><addtitle>Neurotoxicol Teratol</addtitle><date>1991-05-01</date><risdate>1991</risdate><volume>13</volume><issue>3</issue><spage>335</spage><epage>339</epage><pages>335-339</pages><issn>0892-0362</issn><eissn>1872-9738</eissn><coden>NETEEC</coden><abstract>This study investigated whether exposure to cocaine during critical periods of brain development alters the motor stimulating effects of amphetamine given in adulthood. Female rats received 50 mg/kg/day cocaine HCl SC or vehicle during either postnatal days 1–10 or 11–20. At 60–65 days of age, activity counts were collected over a 15-min baseline period. Subjects then received one of 3 doses (0, 0.1, 0.25 mg/kg) of d-amphetamine sulfate SC followed by a 90-min period of activity monitoring. Adult activity in 1–10-day cocaine-treated rats was different from vehicle-treated rats in response to 0.1 mg/kg amphetamine only. Adult activity in 11–20-day cocaine-treated rats was different from vehicle-treated rats in response to 0.25 mg/kg only. The observed differences represented an increase and decrease in activity, respectively. These alterations in amphetamine response may be related to the observed alterations in D-1 receptor concentrations as well as the altered rates of brain glucose metabolism we have observed in adult rats neonatally exposed to cocaine.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1886544</pmid><doi>10.1016/0892-0362(91)90080-G</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neurotoxicology and teratology, 1991-05, Vol.13 (3), p.335-339 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Amphetamine Analysis of Variance Animals Animals, Newborn Biological and medical sciences Body Weight - drug effects Cocaine Cocaine - pharmacology Development Dextroamphetamine - pharmacology Dose-Response Relationship, Drug Drug addictions Female Locomotor activity Medical sciences Motor Activity - drug effects Rats Rats, Inbred Strains Reference Values Toxicology |
| title | Cocaine treatment in neonatal rats affects the adult behavioral response to amphetamine |
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