Coexistence of Impairment of Endothelium-Derived Nitric Oxide and Platelet-Derived Nitric Oxide in Patients With Coronary Risk Factors
Impairment of endothelium-derived nitric oxide (EDNO) has been demonstrated in patients with coronary risk factors in some studies, as well as impaired platelet-derived nitric oxide (PDNO) in other studies. However, no study has examined whether these impairments coexist. In 24 patients with coronar...
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| Veröffentlicht in: | Circulation Journal 2002, Vol.66(9), pp.837-840 |
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| creator | Katoh, Atsushi Ikeda, Hisao Takajo, Yoshinori Haramaki, Nobuya Murohara, Toyoaki Shintani, Satoshi Kanaya, Seiji Yokoyama, Shinji Ueno, Takafumi Honma, Tomoki Imaizumi, Tsutomu |
| description | Impairment of endothelium-derived nitric oxide (EDNO) has been demonstrated in patients with coronary risk factors in some studies, as well as impaired platelet-derived nitric oxide (PDNO) in other studies. However, no study has examined whether these impairments coexist. In 24 patients with coronary risk factors, femoral vascular endothelial function was assessed with acetylcholine (ACh: 50, 100, 200 and 400 μg/min) and endothelium-independent vascular function with nitroglycerin (NTG; 50, 100, 200 μg/min) using a Doppler flow-wire technique, as well as ADP (5 μmol/L)-induced PDNO release with an NO-specific electrode. The ACh-mediated percent change in femoral vascular resistance index (% change of FVRI) and PDNO release had a significant correlation with the number of risk factors. The ACh-mediated % change of FVRI, but not that with NTG, significantly correlated with the PDNO release. Both EDNO and PDNO bioactivities are impaired in patients with coronary risk factors and there is a common mechanism. (Circ J 2002; 66: 837 - 840) |
| doi_str_mv | 10.1253/circj.66.837 |
| format | Article |
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However, no study has examined whether these impairments coexist. In 24 patients with coronary risk factors, femoral vascular endothelial function was assessed with acetylcholine (ACh: 50, 100, 200 and 400 μg/min) and endothelium-independent vascular function with nitroglycerin (NTG; 50, 100, 200 μg/min) using a Doppler flow-wire technique, as well as ADP (5 μmol/L)-induced PDNO release with an NO-specific electrode. The ACh-mediated percent change in femoral vascular resistance index (% change of FVRI) and PDNO release had a significant correlation with the number of risk factors. The ACh-mediated % change of FVRI, but not that with NTG, significantly correlated with the PDNO release. Both EDNO and PDNO bioactivities are impaired in patients with coronary risk factors and there is a common mechanism. 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Vascular system ; Coronary Disease - metabolism ; Coronary heart disease ; Endothelium ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - metabolism ; Female ; Femoral Artery - metabolism ; Heart ; Humans ; Male ; Medical sciences ; Middle Aged ; Nitric oxide ; Nitric Oxide - metabolism ; Platelets ; Risk Factors ; Vasodilator Agents - pharmacology</subject><ispartof>Circulation Journal, 2002, Vol.66(9), pp.837-840</ispartof><rights>2002 THE JAPANESE CIRCULATION SOCIETY</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-2bc79a07476485859fb000a6330dd959aac26b58856f01f53cf35fabc533fa6b3</citedby><cites>FETCH-LOGICAL-c503t-2bc79a07476485859fb000a6330dd959aac26b58856f01f53cf35fabc533fa6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13930394$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12224822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katoh, Atsushi</creatorcontrib><creatorcontrib>Ikeda, Hisao</creatorcontrib><creatorcontrib>Takajo, Yoshinori</creatorcontrib><creatorcontrib>Haramaki, Nobuya</creatorcontrib><creatorcontrib>Murohara, Toyoaki</creatorcontrib><creatorcontrib>Shintani, Satoshi</creatorcontrib><creatorcontrib>Kanaya, Seiji</creatorcontrib><creatorcontrib>Yokoyama, Shinji</creatorcontrib><creatorcontrib>Ueno, Takafumi</creatorcontrib><creatorcontrib>Honma, Tomoki</creatorcontrib><creatorcontrib>Imaizumi, Tsutomu</creatorcontrib><title>Coexistence of Impairment of Endothelium-Derived Nitric Oxide and Platelet-Derived Nitric Oxide in Patients With Coronary Risk Factors</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Impairment of endothelium-derived nitric oxide (EDNO) has been demonstrated in patients with coronary risk factors in some studies, as well as impaired platelet-derived nitric oxide (PDNO) in other studies. However, no study has examined whether these impairments coexist. In 24 patients with coronary risk factors, femoral vascular endothelial function was assessed with acetylcholine (ACh: 50, 100, 200 and 400 μg/min) and endothelium-independent vascular function with nitroglycerin (NTG; 50, 100, 200 μg/min) using a Doppler flow-wire technique, as well as ADP (5 μmol/L)-induced PDNO release with an NO-specific electrode. The ACh-mediated percent change in femoral vascular resistance index (% change of FVRI) and PDNO release had a significant correlation with the number of risk factors. The ACh-mediated % change of FVRI, but not that with NTG, significantly correlated with the PDNO release. Both EDNO and PDNO bioactivities are impaired in patients with coronary risk factors and there is a common mechanism. (Circ J 2002; 66: 837 - 840)</description><subject>Acetylcholine - pharmacology</subject><subject>Aged</subject><subject>Bioactivity</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - drug effects</subject><subject>Blood Platelets - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Disease - metabolism</subject><subject>Coronary heart disease</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Female</subject><subject>Femoral Artery - metabolism</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Platelets</subject><subject>Risk Factors</subject><subject>Vasodilator Agents - pharmacology</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0E9vFCEYBvCJ0dhavXk2XOzJ2TIwMMOxWVtt0tim0Xgk7zAvLusMrMA29Qv4uaXdjXvxwp_wy_OSp6reNnTRMMHPjItmvZBy0fPuWXXc8Lar257R509nWau-5UfVq5TWlDJFhXpZHTWMsWLYcfVnGfDBpYzeIAmWXM0bcHFGnx9vF34MeYWT2871R4zuHkfyxeXoDLl5cCMS8CO5nSDjhPn_wnlyC9mVwES-u7wiyxCDh_ib3Ln0k1yCySGm19ULC1PCN_v9pPp2efF1-bm-vvl0tTy_ro2gPNdsMJ0C2rWdbHvRC2UHSilIzuk4KqEADJOD6HshLW2s4MZyYWEwgnMLcuAn1ekudxPDry2mrGeXDE4TeAzbpDtGu65nvMAPO2hiSCmi1Zvo5vJt3VD92Lt-6l1LqUvvhb_b526HGccD3hddwPs9gGRgshG8cenguOKUq7a4851bpww_8B-AmJ2Z8DBV7ZYy_PC2gqjR878fcaUd</recordid><startdate>20020901</startdate><enddate>20020901</enddate><creator>Katoh, Atsushi</creator><creator>Ikeda, Hisao</creator><creator>Takajo, Yoshinori</creator><creator>Haramaki, Nobuya</creator><creator>Murohara, Toyoaki</creator><creator>Shintani, Satoshi</creator><creator>Kanaya, Seiji</creator><creator>Yokoyama, Shinji</creator><creator>Ueno, Takafumi</creator><creator>Honma, Tomoki</creator><creator>Imaizumi, Tsutomu</creator><general>The Japanese Circulation Society</general><general>Japanese Circulation Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020901</creationdate><title>Coexistence of Impairment of Endothelium-Derived Nitric Oxide and Platelet-Derived Nitric Oxide in Patients With Coronary Risk Factors</title><author>Katoh, Atsushi ; Ikeda, Hisao ; Takajo, Yoshinori ; Haramaki, Nobuya ; Murohara, Toyoaki ; Shintani, Satoshi ; Kanaya, Seiji ; Yokoyama, Shinji ; Ueno, Takafumi ; Honma, Tomoki ; Imaizumi, Tsutomu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-2bc79a07476485859fb000a6330dd959aac26b58856f01f53cf35fabc533fa6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Aged</topic><topic>Bioactivity</topic><topic>Biological and medical sciences</topic><topic>Blood Platelets - drug effects</topic><topic>Blood Platelets - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Disease - metabolism</topic><topic>Coronary heart disease</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Female</topic><topic>Femoral Artery - metabolism</topic><topic>Heart</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Platelets</topic><topic>Risk Factors</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katoh, Atsushi</creatorcontrib><creatorcontrib>Ikeda, Hisao</creatorcontrib><creatorcontrib>Takajo, Yoshinori</creatorcontrib><creatorcontrib>Haramaki, Nobuya</creatorcontrib><creatorcontrib>Murohara, Toyoaki</creatorcontrib><creatorcontrib>Shintani, Satoshi</creatorcontrib><creatorcontrib>Kanaya, Seiji</creatorcontrib><creatorcontrib>Yokoyama, Shinji</creatorcontrib><creatorcontrib>Ueno, Takafumi</creatorcontrib><creatorcontrib>Honma, Tomoki</creatorcontrib><creatorcontrib>Imaizumi, Tsutomu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katoh, Atsushi</au><au>Ikeda, Hisao</au><au>Takajo, Yoshinori</au><au>Haramaki, Nobuya</au><au>Murohara, Toyoaki</au><au>Shintani, Satoshi</au><au>Kanaya, Seiji</au><au>Yokoyama, Shinji</au><au>Ueno, Takafumi</au><au>Honma, Tomoki</au><au>Imaizumi, Tsutomu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coexistence of Impairment of Endothelium-Derived Nitric Oxide and Platelet-Derived Nitric Oxide in Patients With Coronary Risk Factors</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2002-09-01</date><risdate>2002</risdate><volume>66</volume><issue>9</issue><spage>837</spage><epage>840</epage><pages>837-840</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Impairment of endothelium-derived nitric oxide (EDNO) has been demonstrated in patients with coronary risk factors in some studies, as well as impaired platelet-derived nitric oxide (PDNO) in other studies. However, no study has examined whether these impairments coexist. In 24 patients with coronary risk factors, femoral vascular endothelial function was assessed with acetylcholine (ACh: 50, 100, 200 and 400 μg/min) and endothelium-independent vascular function with nitroglycerin (NTG; 50, 100, 200 μg/min) using a Doppler flow-wire technique, as well as ADP (5 μmol/L)-induced PDNO release with an NO-specific electrode. The ACh-mediated percent change in femoral vascular resistance index (% change of FVRI) and PDNO release had a significant correlation with the number of risk factors. The ACh-mediated % change of FVRI, but not that with NTG, significantly correlated with the PDNO release. Both EDNO and PDNO bioactivities are impaired in patients with coronary risk factors and there is a common mechanism. 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| subjects | Acetylcholine - pharmacology Aged Bioactivity Biological and medical sciences Blood Platelets - drug effects Blood Platelets - metabolism Cardiology. Vascular system Coronary Disease - metabolism Coronary heart disease Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Female Femoral Artery - metabolism Heart Humans Male Medical sciences Middle Aged Nitric oxide Nitric Oxide - metabolism Platelets Risk Factors Vasodilator Agents - pharmacology |
| title | Coexistence of Impairment of Endothelium-Derived Nitric Oxide and Platelet-Derived Nitric Oxide in Patients With Coronary Risk Factors |
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