Melatonin inhibits insulin secretion and decreases PKA levels without interfering with glucose metabolism in rat pancreatic islets

: The effect of melatonin (0.1 μM) on freshly isolated islets from adult rats was investigated. Melatonin caused a marked decrease of insulin secretion by islets in response to glucose. The mechanism involved was then examined. Melatonin did not interfere with glucose metabolism as indicated by the...

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Veröffentlicht in:	Journal of pineal research 2002-10, Vol.33 (3), p.156-160
Hauptverfasser:	Picinato, Maria Cecília, Haber, Esther Piltcher, Cipolla-Neto, José, Curi, Rui, De Oliveira Carvalho, Carla Roberta, Carpinelli, Angelo Rafael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Colforsin - pharmacology Cyclic AMP-Dependent Protein Kinases - chemistry Cyclic AMP-Dependent Protein Kinases - metabolism Endocrine pancreas Fundamental and applied biological sciences. Psychology Glucose - metabolism Glucose - pharmacology Hormones. Régulation In Vitro Techniques Insulin - metabolism Insulin Secretion Islets of Langerhans Islets of Langerhans - drug effects Islets of Langerhans - physiology Male melatonin Melatonin - pharmacology pineal PKA PKC Protein Kinase C - chemistry Protein Kinase C - metabolism Protein Subunits Rats Vertebrates: endocrinology
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