Prevalence of Helicobacter Pylori Infection and Its Link to Coronary Risk Factors in Japanese Patients With Acute Myocardial Infarction
The association between Helicobacter pylori (H. pylori) infection and coronary artery disease, as well as the association between H. pylori infection and classic coronary risk factors, is controversial in patients from Western countries. The high prevalence of H. pylori infection in Japanese subject...
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| Veröffentlicht in: | Circulation Journal 2002, Vol.66(9), pp.805-810 |
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| creator | Kinjo, Kunihiro Sato, Hiroshi Sato, Hideyuki Shiotani, Issei Kurotobi, Toshiya Ohnishi, Yozo Hishida, Eiji Nakatani, Daisaku Mizuno, Hiroya Sasaki, Tatsuya Kohama, Akio Abe, Yukichi Morita, Hisaki Kubo, Mitsuaki Takeda, Hiroshi Hori, Masatsugu on Behalf of The Osaka Acute Coronary Insufficiency Study (OACIS) Group |
| description | The association between Helicobacter pylori (H. pylori) infection and coronary artery disease, as well as the association between H. pylori infection and classic coronary risk factors, is controversial in patients from Western countries. The high prevalence of H. pylori infection in Japanese subjects enables an examination of these associations in a large population, especially in young patients, because coronary risk factors may be more strongly associated with younger individuals than with older individuals. The IgG seropositivity to H. pylori was assessed in 618 cases with acute myocardial infarction (AMI) and in 967 controls. The prevalence of seropositivity to H. pylori was similar between cases and controls, but in subjects younger than 55 years, the rate was significantly higher in cases than in controls (58.7% vs 43.3%, p=0.009). After adjustment for age, gender, diabetes mellitus, hypertension, smoking, body mass index, total cholesterol, and high density lipoprotein cholesterol, the odds ratio for acute myocardial infarction was 2.97 (95% confidence interval, 1.37-6.41; p=0.006). Worsening of classic coronary risk factors was not associated with H. pylori infection in subjects younger than 55 years. These results suggest that in younger individuals in Japan, H. pylori infection is significantly associated with AMI independent of the classic coronary risk factors. (Circ J 2002; 66: 805 - 810) |
| doi_str_mv | 10.1253/circj.66.805 |
| format | Article |
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The high prevalence of H. pylori infection in Japanese subjects enables an examination of these associations in a large population, especially in young patients, because coronary risk factors may be more strongly associated with younger individuals than with older individuals. The IgG seropositivity to H. pylori was assessed in 618 cases with acute myocardial infarction (AMI) and in 967 controls. The prevalence of seropositivity to H. pylori was similar between cases and controls, but in subjects younger than 55 years, the rate was significantly higher in cases than in controls (58.7% vs 43.3%, p=0.009). After adjustment for age, gender, diabetes mellitus, hypertension, smoking, body mass index, total cholesterol, and high density lipoprotein cholesterol, the odds ratio for acute myocardial infarction was 2.97 (95% confidence interval, 1.37-6.41; p=0.006). Worsening of classic coronary risk factors was not associated with H. pylori infection in subjects younger than 55 years. These results suggest that in younger individuals in Japan, H. pylori infection is significantly associated with AMI independent of the classic coronary risk factors. (Circ J 2002; 66: 805 - 810)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.66.805</identifier><identifier>PMID: 12224816</identifier><language>eng</language><publisher>Kyoto: The Japanese Circulation Society</publisher><subject>Acute myocardial infarction ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Bacterial - blood ; Biological and medical sciences ; Cardiology. Vascular system ; Case-Control Studies ; Coronary heart disease ; Female ; Heart ; Helicobacter Infections - complications ; Helicobacter Infections - epidemiology ; Helicobacter pylori ; Helicobacter pylori - immunology ; Humans ; Immunoglobulin G - blood ; Japan - epidemiology ; Japanese ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - complications ; Myocardial Infarction - epidemiology ; Myocardial Infarction - microbiology ; Prevalence ; Risk Factors</subject><ispartof>Circulation Journal, 2002, Vol.66(9), pp.805-810</ispartof><rights>2002 THE JAPANESE CIRCULATION SOCIETY</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-ae11ba9611976ee61e52a9686574293e2bbd4e5fa5bf1a43511a7337cd9898ed3</citedby><cites>FETCH-LOGICAL-c479t-ae11ba9611976ee61e52a9686574293e2bbd4e5fa5bf1a43511a7337cd9898ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27926,27927</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13930388$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12224816$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kinjo, Kunihiro</creatorcontrib><creatorcontrib>Sato, Hiroshi</creatorcontrib><creatorcontrib>Sato, Hideyuki</creatorcontrib><creatorcontrib>Shiotani, Issei</creatorcontrib><creatorcontrib>Kurotobi, Toshiya</creatorcontrib><creatorcontrib>Ohnishi, Yozo</creatorcontrib><creatorcontrib>Hishida, Eiji</creatorcontrib><creatorcontrib>Nakatani, Daisaku</creatorcontrib><creatorcontrib>Mizuno, Hiroya</creatorcontrib><creatorcontrib>Sasaki, Tatsuya</creatorcontrib><creatorcontrib>Kohama, Akio</creatorcontrib><creatorcontrib>Abe, Yukichi</creatorcontrib><creatorcontrib>Morita, Hisaki</creatorcontrib><creatorcontrib>Kubo, Mitsuaki</creatorcontrib><creatorcontrib>Takeda, Hiroshi</creatorcontrib><creatorcontrib>Hori, Masatsugu</creatorcontrib><creatorcontrib>on Behalf of The Osaka Acute Coronary Insufficiency Study (OACIS) Group</creatorcontrib><creatorcontrib>Osaka Acute Coronary Insufficiency Study (OACIS) Group</creatorcontrib><title>Prevalence of Helicobacter Pylori Infection and Its Link to Coronary Risk Factors in Japanese Patients With Acute Myocardial Infarction</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>The association between Helicobacter pylori (H. pylori) infection and coronary artery disease, as well as the association between H. pylori infection and classic coronary risk factors, is controversial in patients from Western countries. The high prevalence of H. pylori infection in Japanese subjects enables an examination of these associations in a large population, especially in young patients, because coronary risk factors may be more strongly associated with younger individuals than with older individuals. The IgG seropositivity to H. pylori was assessed in 618 cases with acute myocardial infarction (AMI) and in 967 controls. The prevalence of seropositivity to H. pylori was similar between cases and controls, but in subjects younger than 55 years, the rate was significantly higher in cases than in controls (58.7% vs 43.3%, p=0.009). After adjustment for age, gender, diabetes mellitus, hypertension, smoking, body mass index, total cholesterol, and high density lipoprotein cholesterol, the odds ratio for acute myocardial infarction was 2.97 (95% confidence interval, 1.37-6.41; p=0.006). Worsening of classic coronary risk factors was not associated with H. pylori infection in subjects younger than 55 years. These results suggest that in younger individuals in Japan, H. pylori infection is significantly associated with AMI independent of the classic coronary risk factors. (Circ J 2002; 66: 805 - 810)</description><subject>Acute myocardial infarction</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies, Bacterial - blood</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Coronary heart disease</subject><subject>Female</subject><subject>Heart</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter Infections - epidemiology</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - immunology</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Japan - epidemiology</subject><subject>Japanese</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Myocardial Infarction - microbiology</subject><subject>Prevalence</subject><subject>Risk Factors</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFvEzEQhS0Eom3gxhn5Qk9sWNu7XvsYRZQGBREhqh5Xs95Z6nRjB9uplF_A366bRORie-TvvZl5hHxg5ZTxWnwxNpj1VMqpKutX5JKJqikqxcvXh7cstKrEBbmKcV2WXJe1fksuGOe8Ukxekn-rgE8wojNI_UBvcbTGd2ASBrrajz5YunADmmS9o-B6ukiRLq17pMnTuQ_eQdjTXzY-0pus8iFS6-h32ILDiHQFyaLLknubHujM7BLSH3tvIPQWxhdrCAfvd-TNAGPE96d7Qu5uvv6e3xbLn98W89myMFWjUwHIWAdaMqYbiSgZ1jyXStZNxbVA3nV9hfUAdTcwqETNGDRCNKbXSivsxYRcH323wf_dYUztxkaD45jn9bvYNrxsap0lE_L5CJrgYww4tNtgN3nZlpXtS_DtIfhWyjYHn_GPJ99dt8H-DJ-SzsCnEwDRwDgEcMbGMye0KIVSmZsduXVM8Af_AxCSNSOeu-rjkZuf_x4gtOjEM6b_pWc</recordid><startdate>20020901</startdate><enddate>20020901</enddate><creator>Kinjo, Kunihiro</creator><creator>Sato, Hiroshi</creator><creator>Sato, Hideyuki</creator><creator>Shiotani, Issei</creator><creator>Kurotobi, Toshiya</creator><creator>Ohnishi, Yozo</creator><creator>Hishida, Eiji</creator><creator>Nakatani, Daisaku</creator><creator>Mizuno, Hiroya</creator><creator>Sasaki, Tatsuya</creator><creator>Kohama, Akio</creator><creator>Abe, Yukichi</creator><creator>Morita, Hisaki</creator><creator>Kubo, Mitsuaki</creator><creator>Takeda, Hiroshi</creator><creator>Hori, Masatsugu</creator><creator>on Behalf of The Osaka Acute Coronary Insufficiency Study (OACIS) Group</creator><general>The Japanese Circulation Society</general><general>Japanese Circulation Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020901</creationdate><title>Prevalence of Helicobacter Pylori Infection and Its Link to Coronary Risk Factors in Japanese Patients With Acute Myocardial Infarction</title><author>Kinjo, Kunihiro ; Sato, Hiroshi ; Sato, Hideyuki ; Shiotani, Issei ; Kurotobi, Toshiya ; Ohnishi, Yozo ; Hishida, Eiji ; Nakatani, Daisaku ; Mizuno, Hiroya ; Sasaki, Tatsuya ; Kohama, Akio ; Abe, Yukichi ; Morita, Hisaki ; Kubo, Mitsuaki ; Takeda, Hiroshi ; Hori, Masatsugu ; on Behalf of The Osaka Acute Coronary Insufficiency Study (OACIS) Group</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-ae11ba9611976ee61e52a9686574293e2bbd4e5fa5bf1a43511a7337cd9898ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acute myocardial infarction</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies, Bacterial - blood</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Coronary heart disease</topic><topic>Female</topic><topic>Heart</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter Infections - epidemiology</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - immunology</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Japan - epidemiology</topic><topic>Japanese</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - epidemiology</topic><topic>Myocardial Infarction - microbiology</topic><topic>Prevalence</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kinjo, Kunihiro</creatorcontrib><creatorcontrib>Sato, Hiroshi</creatorcontrib><creatorcontrib>Sato, Hideyuki</creatorcontrib><creatorcontrib>Shiotani, Issei</creatorcontrib><creatorcontrib>Kurotobi, Toshiya</creatorcontrib><creatorcontrib>Ohnishi, Yozo</creatorcontrib><creatorcontrib>Hishida, Eiji</creatorcontrib><creatorcontrib>Nakatani, Daisaku</creatorcontrib><creatorcontrib>Mizuno, Hiroya</creatorcontrib><creatorcontrib>Sasaki, Tatsuya</creatorcontrib><creatorcontrib>Kohama, Akio</creatorcontrib><creatorcontrib>Abe, Yukichi</creatorcontrib><creatorcontrib>Morita, Hisaki</creatorcontrib><creatorcontrib>Kubo, Mitsuaki</creatorcontrib><creatorcontrib>Takeda, Hiroshi</creatorcontrib><creatorcontrib>Hori, Masatsugu</creatorcontrib><creatorcontrib>on Behalf of The Osaka Acute Coronary Insufficiency Study (OACIS) Group</creatorcontrib><creatorcontrib>Osaka Acute Coronary Insufficiency Study (OACIS) Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kinjo, Kunihiro</au><au>Sato, Hiroshi</au><au>Sato, Hideyuki</au><au>Shiotani, Issei</au><au>Kurotobi, Toshiya</au><au>Ohnishi, Yozo</au><au>Hishida, Eiji</au><au>Nakatani, Daisaku</au><au>Mizuno, Hiroya</au><au>Sasaki, Tatsuya</au><au>Kohama, Akio</au><au>Abe, Yukichi</au><au>Morita, Hisaki</au><au>Kubo, Mitsuaki</au><au>Takeda, Hiroshi</au><au>Hori, Masatsugu</au><au>on Behalf of The Osaka Acute Coronary Insufficiency Study (OACIS) Group</au><aucorp>Osaka Acute Coronary Insufficiency Study (OACIS) Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of Helicobacter Pylori Infection and Its Link to Coronary Risk Factors in Japanese Patients With Acute Myocardial Infarction</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2002-09-01</date><risdate>2002</risdate><volume>66</volume><issue>9</issue><spage>805</spage><epage>810</epage><pages>805-810</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>The association between Helicobacter pylori (H. pylori) infection and coronary artery disease, as well as the association between H. pylori infection and classic coronary risk factors, is controversial in patients from Western countries. The high prevalence of H. pylori infection in Japanese subjects enables an examination of these associations in a large population, especially in young patients, because coronary risk factors may be more strongly associated with younger individuals than with older individuals. The IgG seropositivity to H. pylori was assessed in 618 cases with acute myocardial infarction (AMI) and in 967 controls. The prevalence of seropositivity to H. pylori was similar between cases and controls, but in subjects younger than 55 years, the rate was significantly higher in cases than in controls (58.7% vs 43.3%, p=0.009). After adjustment for age, gender, diabetes mellitus, hypertension, smoking, body mass index, total cholesterol, and high density lipoprotein cholesterol, the odds ratio for acute myocardial infarction was 2.97 (95% confidence interval, 1.37-6.41; p=0.006). Worsening of classic coronary risk factors was not associated with H. pylori infection in subjects younger than 55 years. These results suggest that in younger individuals in Japan, H. pylori infection is significantly associated with AMI independent of the classic coronary risk factors. (Circ J 2002; 66: 805 - 810)</abstract><cop>Kyoto</cop><pub>The Japanese Circulation Society</pub><pmid>12224816</pmid><doi>10.1253/circj.66.805</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Circulation Journal, 2002, Vol.66(9), pp.805-810 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Acute myocardial infarction Adult Aged Aged, 80 and over Antibodies, Bacterial - blood Biological and medical sciences Cardiology. Vascular system Case-Control Studies Coronary heart disease Female Heart Helicobacter Infections - complications Helicobacter Infections - epidemiology Helicobacter pylori Helicobacter pylori - immunology Humans Immunoglobulin G - blood Japan - epidemiology Japanese Logistic Models Male Medical sciences Middle Aged Myocardial Infarction - complications Myocardial Infarction - epidemiology Myocardial Infarction - microbiology Prevalence Risk Factors |
| title | Prevalence of Helicobacter Pylori Infection and Its Link to Coronary Risk Factors in Japanese Patients With Acute Myocardial Infarction |
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