Resistance to killing by tumor necrosis factor in an adipocyte cell line caused by a defect in arachidonic acid biosynthesis

We have found that TA1-R6, which are resistant to the cytotoxic effects of tumor necrosis factor (TNF) in the presence of cycloheximide (Reid, T. R., Torti, F., and Ringold, G. M. (1989) J. Biol. Chem. 264, 4583-4589), have reduced ability to release arachidonic acid (20:4) from membrane phospholipi...

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Veröffentlicht in:	The Journal of biological chemistry 1991-09, Vol.266 (25), p.16580-16586
Hauptverfasser:	REID, T, RAMESHA, C. S, RINGOLD, G. M
Format:	Artikel
Sprache:	eng
Schlagworte:	adipocytes Adipose Tissue - cytology Adipose Tissue - drug effects Adipose Tissue - metabolism Arachidonic Acid Arachidonic Acids - biosynthesis Biological and medical sciences Calcimycin - pharmacology Cell Line Cell physiology Cell Survival - drug effects Cycloheximide - pharmacology Drug Resistance Fatty Acid Desaturases - metabolism Fatty Acids - metabolism Fundamental and applied biological sciences. Psychology Kinetics Linoleoyl-CoA Desaturase Molecular and cellular biology Phospholipids - metabolism Responses to growth factors, tumor promotors, other factors Tumor Necrosis Factor-alpha - pharmacology
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