Nonimmune IgM, but not IgG binds to the surface of Plasmodium falciparum-infected erythrocytes and correlates with rosetting and severe malaria

Recent work suggests that IgG and IgM from nonimmune human serum (natural antibodies) bind to the surface of Plasmodium falciparum-infected erythrocytes and contribute to rosette formation by stabilizing the interaction between infected and uninfected erythrocytes. Here we show, in both laboratory c...

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Veröffentlicht in:	The American journal of tropical medicine and hygiene 2002-06, Vol.66 (6), p.692-699
Hauptverfasser:	Rowe, JA, Shafi, J, Kai, OK, Marsh, K, Raza, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Binding Sites, Antibody Biological and medical sciences Erythrocytes - parasitology Human protozoal diseases Humans Immunoglobulin G - immunology Immunoglobulin M - immunology Infectious diseases Malaria Malaria, Falciparum - blood Malaria, Falciparum - diagnosis Malaria, Falciparum - immunology Medical sciences Parasitic diseases Plasmodium Plasmodium falciparum Plasmodium falciparum - immunology Protozoal diseases Reproducibility of Results Rosette Formation - methods Sensitivity and Specificity Tropical medicine
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