Characterization of a novel diolein-based LPDII vector for gene delivery

LPDII vectors are non-viral vehicles for gene delivery comprised of polycation-condensed plasmid DNA (polyplexes) complexed with anionic pH-sensitive liposomes. Here, we describe a novel LPDII formulation containing polyethylenimine (PEI) polyplexes complexed with anionic pH-sensitive liposomes comp...

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Veröffentlicht in:	Journal of controlled release 2002-09, Vol.83 (1), p.121-132
Hauptverfasser:	Guo, Wenjin, Gosselin, Michael A, Lee, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Diglycerides - administration & dosage Diglycerides - chemistry Diglycerides - pharmacokinetics Diolein Drug Delivery Systems - methods Gene therapy General pharmacology Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - chemistry Genetic Vectors - pharmacokinetics Humans Liposomes LPDII Medical sciences Mice Non-viral vectors pH-sensitive liposomes Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Plasmids - administration & dosage Plasmids - chemistry Plasmids - pharmacokinetics Polyethyleneimine - administration & dosage Polyethyleneimine - chemistry Polyethyleneimine - pharmacokinetics Polyethylenimine Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism
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