Antibody Binding to Fas Ligand Attenuates Inflammatory Cell Infiltration and Cytokine Secretion, Leading to Reduction of Myocardial Infarct Areas and Reperfusion Injury

Fas ligand (FasL) induces apoptotic cell death when bound to Fas antigen. The engagement of FasL has anti-inflammatory effects through the prevention of cell proliferation and cytokine secretion. However, the role of FasL in myocardial ischemia/reperfusion (MI/R) injury is unclear. We examined the e...

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Veröffentlicht in:	Laboratory investigation 2002-09, Vol.82 (9), p.1121-1129
Hauptverfasser:	Shiraishi, Hirokazu, Toyozaki, Tetsuya, Tsukamoto, Yoshiaki, Saito, Toshihiro, Masuda, Yoshiaki, Hiroshima, Kenzo, Ohwada, Hidemi, Kobayashi, Nobuyuki, Hiroe, Michiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - therapeutic use Apoptosis Biological and medical sciences Cardiovascular system Chemokine CCL2 - physiology Cytokines - biosynthesis Fas Ligand Protein Laboratory Medicine Male Medical sciences Medicine Medicine & Public Health Membrane Glycoproteins - genetics Membrane Glycoproteins - immunology Membrane Glycoproteins - physiology Miscellaneous Myocardial Infarction - immunology Myocardial Infarction - pathology Myocardial Infarction - therapy Myocardial Reperfusion Injury - prevention & control Neutrophils - physiology Pathology Pharmacology. Drug treatments Rats Rats, Sprague-Dawley RNA, Messenger - analysis
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