Substratum regulation of neurite fasciculation
A new clonal nerve-like cell line from the rat eye is used to show that cell-substratum adhesion can modulate neurite fasciculation. When cells are grown on a substratum of intermediate adhesiveness their neurites adhere to each other and form fascicles. In contrast, cells grown on more adhesive sur...
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| Veröffentlicht in: | Brain research 1991-05, Vol.549 (2), p.305-310 |
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| container_title | Brain research |
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| creator | Schubert, David Klier, F. George |
| description | A new clonal nerve-like cell line from the rat eye is used to show that cell-substratum adhesion can modulate neurite fasciculation. When cells are grown on a substratum of intermediate adhesiveness their neurites adhere to each other and form fascicles. In contrast, cells grown on more adhesive surfaces spread and extend individual neurites. The direct relationship between the initial rates of cell-substratum adhesion and neurite fasciculation shows that the extent of axon fasciculation which occurs in vivo may be determined by the extracellular environment through which the axons are growing. |
| doi_str_mv | 10.1016/0006-8993(91)90472-8 |
| format | Article |
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The direct relationship between the initial rates of cell-substratum adhesion and neurite fasciculation shows that the extent of axon fasciculation which occurs in vivo may be determined by the extracellular environment through which the axons are growing.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(91)90472-8</identifier><identifier>PMID: 1884223</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Adhesion ; Animals ; Axons - physiology ; Biological and medical sciences ; Cell Adhesion ; Cell Line ; Chemotaxis - drug effects ; Clonal cell line ; Clone Cells ; Eye - cytology ; Fasciculation ; Fundamental and applied biological sciences. Psychology ; Isolated neuron and nerve. 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The direct relationship between the initial rates of cell-substratum adhesion and neurite fasciculation shows that the extent of axon fasciculation which occurs in vivo may be determined by the extracellular environment through which the axons are growing.</description><subject>Adhesion</subject><subject>Animals</subject><subject>Axons - physiology</subject><subject>Biological and medical sciences</subject><subject>Cell Adhesion</subject><subject>Cell Line</subject><subject>Chemotaxis - drug effects</subject><subject>Clonal cell line</subject><subject>Clone Cells</subject><subject>Eye - cytology</subject><subject>Fasciculation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Isolated neuron and nerve. Neuroglia</subject><subject>Leucine - metabolism</subject><subject>Microscopy, Electron</subject><subject>Nerve</subject><subject>Neurons - physiology</subject><subject>Rats</subject><subject>Substratum</subject><subject>Tumor Cells, Cultured - ultrastructure</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoMo4zj6BgrdKLromEvbJBtBBm8w4EJdhzQ9kUgvY9IKvr0ZW5ydqyT83384-RA6JXhJMCmuMcZFKqRkl5JcSZxxmoo9NCciXgqa4X00_0MO0VEIH_HJmMQzNCNCZJSyOVq-DGXove6HJvHwPtS6d12bdDZpYfCuh8TqYJyZgmN0YHUd4GQ6F-jt_u519Ziunx-eVrfr1DDB-1QIClQDJYZCbkgODOdc8IrKUlsglrO8qMocF4JmAliVW8wtiy1eEQK8Ygt0Mc7d-O5zgNCrxgUDda1b6IagOMWcZSSLYDaCxncheLBq412j_bciWG01qa0DtXWgJFG_mpSItbNp_lA2UO1Ko5eYn095_L2urdetcWGHyULmRNDI3YwcRBlfDryKsqA1UDkPpldV5_5f5Ae2F4Ki</recordid><startdate>19910524</startdate><enddate>19910524</enddate><creator>Schubert, David</creator><creator>Klier, F. 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Neuroglia</topic><topic>Leucine - metabolism</topic><topic>Microscopy, Electron</topic><topic>Nerve</topic><topic>Neurons - physiology</topic><topic>Rats</topic><topic>Substratum</topic><topic>Tumor Cells, Cultured - ultrastructure</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schubert, David</creatorcontrib><creatorcontrib>Klier, F. George</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schubert, David</au><au>Klier, F. George</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Substratum regulation of neurite fasciculation</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1991-05-24</date><risdate>1991</risdate><volume>549</volume><issue>2</issue><spage>305</spage><epage>310</epage><pages>305-310</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>A new clonal nerve-like cell line from the rat eye is used to show that cell-substratum adhesion can modulate neurite fasciculation. When cells are grown on a substratum of intermediate adhesiveness their neurites adhere to each other and form fascicles. In contrast, cells grown on more adhesive surfaces spread and extend individual neurites. 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| ispartof | Brain research, 1991-05, Vol.549 (2), p.305-310 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adhesion Animals Axons - physiology Biological and medical sciences Cell Adhesion Cell Line Chemotaxis - drug effects Clonal cell line Clone Cells Eye - cytology Fasciculation Fundamental and applied biological sciences. Psychology Isolated neuron and nerve. Neuroglia Leucine - metabolism Microscopy, Electron Nerve Neurons - physiology Rats Substratum Tumor Cells, Cultured - ultrastructure Vertebrates: nervous system and sense organs |
| title | Substratum regulation of neurite fasciculation |
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