An overview of homologous pairing and DNA strand exchange proteins
Processes fundamental to all models of genetic recombination include the homologous pairing and subsequent exchange of DNA strands. Biochemical analysis of these events has been conducted primarily on the recA protein of Escherichia coli, although proteins which can promote such reactions have been...
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| Veröffentlicht in: | Biochimie 1991-02, Vol.73 (2), p.163-176 |
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| container_title | Biochimie |
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| creator | Eggleston, A.K. Kowalczykowski, S.C. |
| description | Processes fundamental to all models of genetic recombination include the homologous pairing and subsequent exchange of DNA strands. Biochemical analysis of these events has been conducted primarily on the recA protein of
Escherichia coli, although proteins which can promote such reactions have been purified from many sources, both prokaryotic and eukaryotic. The activities of these homologous pairing and DNA strand exchange proteins are either ATP-dependent, as predicted based on the recA protein paradigm, or, more unexpectedly, ATP-independent. This review examines the reactions promoted by both classes of proteins and highlights their similarities and differences. The mechanistic implications of the apparent existence of 2 classes of strand exchange protein are discussed. |
| doi_str_mv | 10.1016/0300-9084(91)90199-B |
| format | Article |
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Escherichia coli, although proteins which can promote such reactions have been purified from many sources, both prokaryotic and eukaryotic. The activities of these homologous pairing and DNA strand exchange proteins are either ATP-dependent, as predicted based on the recA protein paradigm, or, more unexpectedly, ATP-independent. This review examines the reactions promoted by both classes of proteins and highlights their similarities and differences. The mechanistic implications of the apparent existence of 2 classes of strand exchange protein are discussed.</description><subject>Adenosine Triphosphatases - metabolism</subject><subject>Adenosine Triphosphate - pharmacology</subject><subject>Animals</subject><subject>Base Composition</subject><subject>Biological and medical sciences</subject><subject>DNA - metabolism</subject><subject>DNA Helicases</subject><subject>DNA strand exchange</subject><subject>DNA, Single-Stranded - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>genetic recombination</subject><subject>Genic rearrangement. Recombination. Transposable element</subject><subject>homologous pairing</subject><subject>Humans</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Nucleotidyltransferases - metabolism</subject><subject>Peptide Hydrolases - metabolism</subject><subject>Rec A Recombinases - metabolism</subject><subject>recA protein</subject><subject>Sequence Homology, Nucleic Acid</subject><issn>0300-9084</issn><issn>1638-6183</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PwzAMhiMEGmPwD0DqBQSHgtP0I7kgbeNTmuAC5yhL3S2oa0bSDfj3pGyCGydb8mP71UPIMYVLCjS_AgYQC-DpuaAXAqgQ8WiH9GnOeJxTznZJ_xfZJwfevwFABonokR7NMwaM9slo2ER2jW5t8COyVTS3C1vbmV35aKmMM80sUk0Z3TwNI9-6rsVPPVfNDKOlsy2axh-SvUrVHo-2dUBe725fxg_x5Pn-cTycxDplvI05FjottAJW5krQYsp1xkFrLDKmEoVTzDWkSV6yYgopVKCRiQKBVUJxSCo2IGebu-Hx-wp9KxfGa6xr1WDIK4sEiiTLeADTDaid9d5hJZfOLJT7khRkp052XmTnRQoqf9TJUVg72d5fTRdY_i1tXIX56XauvFZ1FWxo4_8wkQlGQQTuesNhkBG8Oum1wUZjaRzqVpbW_B_kG46hicg</recordid><startdate>19910201</startdate><enddate>19910201</enddate><creator>Eggleston, A.K.</creator><creator>Kowalczykowski, S.C.</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910201</creationdate><title>An overview of homologous pairing and DNA strand exchange proteins</title><author>Eggleston, A.K. ; Kowalczykowski, S.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-8e7c47ca03d6a917b8c580cce753a2aebe6c0426d37b040f0ce397e03f9a802f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adenosine Triphosphatases - metabolism</topic><topic>Adenosine Triphosphate - pharmacology</topic><topic>Animals</topic><topic>Base Composition</topic><topic>Biological and medical sciences</topic><topic>DNA - metabolism</topic><topic>DNA Helicases</topic><topic>DNA strand exchange</topic><topic>DNA, Single-Stranded - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>genetic recombination</topic><topic>Genic rearrangement. Recombination. Transposable element</topic><topic>homologous pairing</topic><topic>Humans</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Nucleotidyltransferases - metabolism</topic><topic>Peptide Hydrolases - metabolism</topic><topic>Rec A Recombinases - metabolism</topic><topic>recA protein</topic><topic>Sequence Homology, Nucleic Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eggleston, A.K.</creatorcontrib><creatorcontrib>Kowalczykowski, S.C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochimie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eggleston, A.K.</au><au>Kowalczykowski, S.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An overview of homologous pairing and DNA strand exchange proteins</atitle><jtitle>Biochimie</jtitle><addtitle>Biochimie</addtitle><date>1991-02-01</date><risdate>1991</risdate><volume>73</volume><issue>2</issue><spage>163</spage><epage>176</epage><pages>163-176</pages><issn>0300-9084</issn><eissn>1638-6183</eissn><coden>BICMBE</coden><abstract>Processes fundamental to all models of genetic recombination include the homologous pairing and subsequent exchange of DNA strands. Biochemical analysis of these events has been conducted primarily on the recA protein of
Escherichia coli, although proteins which can promote such reactions have been purified from many sources, both prokaryotic and eukaryotic. The activities of these homologous pairing and DNA strand exchange proteins are either ATP-dependent, as predicted based on the recA protein paradigm, or, more unexpectedly, ATP-independent. This review examines the reactions promoted by both classes of proteins and highlights their similarities and differences. The mechanistic implications of the apparent existence of 2 classes of strand exchange protein are discussed.</abstract><cop>Paris</cop><pub>Elsevier Masson SAS</pub><pmid>1653031</pmid><doi>10.1016/0300-9084(91)90199-B</doi><tpages>14</tpages></addata></record> |
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| ispartof | Biochimie, 1991-02, Vol.73 (2), p.163-176 |
| issn | 0300-9084 1638-6183 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72072558 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adenosine Triphosphatases - metabolism Adenosine Triphosphate - pharmacology Animals Base Composition Biological and medical sciences DNA - metabolism DNA Helicases DNA strand exchange DNA, Single-Stranded - metabolism Fundamental and applied biological sciences. Psychology genetic recombination Genic rearrangement. Recombination. Transposable element homologous pairing Humans Molecular and cellular biology Molecular genetics Nucleotidyltransferases - metabolism Peptide Hydrolases - metabolism Rec A Recombinases - metabolism recA protein Sequence Homology, Nucleic Acid |
| title | An overview of homologous pairing and DNA strand exchange proteins |
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