Evaluation of Once-Daily Levobunolol 0.25% and Timolol 0.25% Therapy for Increased Intraocular Pressure
In a three-month, double-masked, randomized clinical trial, we evaluated the once-daily ocular hypotensive efficacy of 0.25% levobunolol and 0.25% timolol in 80 patients with open-angle glaucoma or ocular hypertension. Thirty-seven of the 39 patients (95%) in the 0.25% levobunolol group and 35 of th...
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| Veröffentlicht in: | American journal of ophthalmology 1991-07, Vol.112 (1), p.56-60 |
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| container_title | American journal of ophthalmology |
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| creator | Silverstone, David Zimmerman, Thom Choplin, Cdr Neil Mundorf, Tom Rose, Aron Stoecker, Jack Kelley, Elaine Lue, John |
| description | In a three-month, double-masked, randomized clinical trial, we evaluated the once-daily ocular hypotensive efficacy of 0.25% levobunolol and 0.25% timolol in 80 patients with open-angle glaucoma or ocular hypertension. Thirty-seven of the 39 patients (95%) in the 0.25% levobunolol group and 35 of the 41 patients (85%) in the 0.25% timolol group successfully completed the three-month study period. The overall mean decrease in intraocular pressure was 5.3 mm Hg (22%) in the 0.25% levobunolol group and 5.4 mm Hg (22%) in the 0.25% timolol group. This difference was not statistically significant. In both treatment groups, effects on mean heart rate and blood pressure were minimal. The data suggest that levobunolol 0.25% and timolol 0.25%, administered once dally, are equally effective in the treatment of open-angle glaucoma and ocular hypertension. |
| doi_str_mv | 10.1016/S0002-9394(14)76213-0 |
| format | Article |
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Thirty-seven of the 39 patients (95%) in the 0.25% levobunolol group and 35 of the 41 patients (85%) in the 0.25% timolol group successfully completed the three-month study period. The overall mean decrease in intraocular pressure was 5.3 mm Hg (22%) in the 0.25% levobunolol group and 5.4 mm Hg (22%) in the 0.25% timolol group. This difference was not statistically significant. In both treatment groups, effects on mean heart rate and blood pressure were minimal. The data suggest that levobunolol 0.25% and timolol 0.25%, administered once dally, are equally effective in the treatment of open-angle glaucoma and ocular hypertension.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/S0002-9394(14)76213-0</identifier><identifier>PMID: 1882923</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Double-Blind Method ; Drug Administration Schedule ; Evaluation Studies as Topic ; Eye ; Female ; Glaucoma, Open-Angle - drug therapy ; Humans ; Intraocular Pressure - drug effects ; Levobunolol - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Ocular Hypertension - drug therapy ; Ophthalmic Solutions ; Pharmacology. Drug treatments ; Timolol - therapeutic use</subject><ispartof>American journal of ophthalmology, 1991-07, Vol.112 (1), p.56-60</ispartof><rights>1991 Elsevier Inc.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c304t-e22d28e52b2a77c7dab1e54b96e12ce0f57a30a0ce16b3f49354e65773f683123</citedby><cites>FETCH-LOGICAL-c304t-e22d28e52b2a77c7dab1e54b96e12ce0f57a30a0ce16b3f49354e65773f683123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0002-9394(14)76213-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5597766$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1882923$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silverstone, David</creatorcontrib><creatorcontrib>Zimmerman, Thom</creatorcontrib><creatorcontrib>Choplin, Cdr Neil</creatorcontrib><creatorcontrib>Mundorf, Tom</creatorcontrib><creatorcontrib>Rose, Aron</creatorcontrib><creatorcontrib>Stoecker, Jack</creatorcontrib><creatorcontrib>Kelley, Elaine</creatorcontrib><creatorcontrib>Lue, John</creatorcontrib><title>Evaluation of Once-Daily Levobunolol 0.25% and Timolol 0.25% Therapy for Increased Intraocular Pressure</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>In a three-month, double-masked, randomized clinical trial, we evaluated the once-daily ocular hypotensive efficacy of 0.25% levobunolol and 0.25% timolol in 80 patients with open-angle glaucoma or ocular hypertension. Thirty-seven of the 39 patients (95%) in the 0.25% levobunolol group and 35 of the 41 patients (85%) in the 0.25% timolol group successfully completed the three-month study period. The overall mean decrease in intraocular pressure was 5.3 mm Hg (22%) in the 0.25% levobunolol group and 5.4 mm Hg (22%) in the 0.25% timolol group. This difference was not statistically significant. In both treatment groups, effects on mean heart rate and blood pressure were minimal. The data suggest that levobunolol 0.25% and timolol 0.25%, administered once dally, are equally effective in the treatment of open-angle glaucoma and ocular hypertension.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Double-Blind Method</subject><subject>Drug Administration Schedule</subject><subject>Evaluation Studies as Topic</subject><subject>Eye</subject><subject>Female</subject><subject>Glaucoma, Open-Angle - drug therapy</subject><subject>Humans</subject><subject>Intraocular Pressure - drug effects</subject><subject>Levobunolol - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ocular Hypertension - drug therapy</subject><subject>Ophthalmic Solutions</subject><subject>Pharmacology. Drug treatments</subject><subject>Timolol - therapeutic use</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EKkvhJ1TyASp6SOuP2I5PCPUDKq3USixna-JMwMgbL3ay0v57st1V4cbJY7_PjEcPIWecXXLG9dU3xpiorLT1R15fGC24rNgLsuCNsRVvLH9JFs_Ia_KmlF_zVZvanJAT3jTCCrkgP263ECcYQxpo6unD4LG6gRB3dInb1E5DiilSdinUBwpDR1dh_c_L6idm2OxonzK9H3xGKNjN1Zgh-SlCpo8ZS5kyviWveogF3x3PU_L97nZ1_bVaPny5v_68rLxk9VihEJ1oUIlWgDHedNByVHVrNXLhkfXKgGTAPHLdyr62UtWolTGy143kQp6S88PcTU6_JyyjW4fiMUYYME3FGcGMkHYPqgPocyolY-82Oawh7xxnbi_YPQl2e3uO1-5JsGNz39nxg6ldY_e362B0zt8fcygeYp9h8KE8Y0pZY7SesU8HDGcZ24DZFR9wtt-FjH50XQr_WeQPrS2VfA</recordid><startdate>19910715</startdate><enddate>19910715</enddate><creator>Silverstone, David</creator><creator>Zimmerman, Thom</creator><creator>Choplin, Cdr Neil</creator><creator>Mundorf, Tom</creator><creator>Rose, Aron</creator><creator>Stoecker, Jack</creator><creator>Kelley, Elaine</creator><creator>Lue, John</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910715</creationdate><title>Evaluation of Once-Daily Levobunolol 0.25% and Timolol 0.25% Therapy for Increased Intraocular Pressure</title><author>Silverstone, David ; Zimmerman, Thom ; Choplin, Cdr Neil ; Mundorf, Tom ; Rose, Aron ; Stoecker, Jack ; Kelley, Elaine ; Lue, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c304t-e22d28e52b2a77c7dab1e54b96e12ce0f57a30a0ce16b3f49354e65773f683123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Double-Blind Method</topic><topic>Drug Administration Schedule</topic><topic>Evaluation Studies as Topic</topic><topic>Eye</topic><topic>Female</topic><topic>Glaucoma, Open-Angle - drug therapy</topic><topic>Humans</topic><topic>Intraocular Pressure - drug effects</topic><topic>Levobunolol - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ocular Hypertension - drug therapy</topic><topic>Ophthalmic Solutions</topic><topic>Pharmacology. Drug treatments</topic><topic>Timolol - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silverstone, David</creatorcontrib><creatorcontrib>Zimmerman, Thom</creatorcontrib><creatorcontrib>Choplin, Cdr Neil</creatorcontrib><creatorcontrib>Mundorf, Tom</creatorcontrib><creatorcontrib>Rose, Aron</creatorcontrib><creatorcontrib>Stoecker, Jack</creatorcontrib><creatorcontrib>Kelley, Elaine</creatorcontrib><creatorcontrib>Lue, John</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silverstone, David</au><au>Zimmerman, Thom</au><au>Choplin, Cdr Neil</au><au>Mundorf, Tom</au><au>Rose, Aron</au><au>Stoecker, Jack</au><au>Kelley, Elaine</au><au>Lue, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Once-Daily Levobunolol 0.25% and Timolol 0.25% Therapy for Increased Intraocular Pressure</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>1991-07-15</date><risdate>1991</risdate><volume>112</volume><issue>1</issue><spage>56</spage><epage>60</epage><pages>56-60</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>In a three-month, double-masked, randomized clinical trial, we evaluated the once-daily ocular hypotensive efficacy of 0.25% levobunolol and 0.25% timolol in 80 patients with open-angle glaucoma or ocular hypertension. Thirty-seven of the 39 patients (95%) in the 0.25% levobunolol group and 35 of the 41 patients (85%) in the 0.25% timolol group successfully completed the three-month study period. The overall mean decrease in intraocular pressure was 5.3 mm Hg (22%) in the 0.25% levobunolol group and 5.4 mm Hg (22%) in the 0.25% timolol group. This difference was not statistically significant. In both treatment groups, effects on mean heart rate and blood pressure were minimal. The data suggest that levobunolol 0.25% and timolol 0.25%, administered once dally, are equally effective in the treatment of open-angle glaucoma and ocular hypertension.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1882923</pmid><doi>10.1016/S0002-9394(14)76213-0</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Double-Blind Method Drug Administration Schedule Evaluation Studies as Topic Eye Female Glaucoma, Open-Angle - drug therapy Humans Intraocular Pressure - drug effects Levobunolol - therapeutic use Male Medical sciences Middle Aged Ocular Hypertension - drug therapy Ophthalmic Solutions Pharmacology. Drug treatments Timolol - therapeutic use |
| title | Evaluation of Once-Daily Levobunolol 0.25% and Timolol 0.25% Therapy for Increased Intraocular Pressure |
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