Enhanced thromboxane synthesis during chronic reductions in uterine perfusion pressure in pregnant rats

The purpose of this study was to determine the role of thromboxane A 2 (TXA 2) in a conscious, chronically instrumented rat model of pregnancy-induced hypertension (PIH) produced by chronic reductions in uterine perfusion pressure (RUPP). Mean arterial pressure (MAP), glomerular filtration rate (GFR...

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Veröffentlicht in:	American journal of hypertension 2002-09, Vol.15 (9), p.793-797
Hauptverfasser:	Llinás, Maria T, Alexander, Barbara T, Seedek, Mona, Abram, Sean R, Crell, Anna, Granger, Joey P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Bridged Bicyclo Compounds, Heterocyclic Cardiology. Vascular system Disease Models, Animal Experimental diseases Fatty Acids, Unsaturated Female Hydrazines - pharmacology Hypertension Hypertension - physiopathology Medical sciences Pre-Eclampsia - physiopathology preeclampsia Pregnancy Pregnancy Complications, Cardiovascular - physiopathology Rats Renal Circulation - drug effects Renal Circulation - physiology thromboxane Thromboxane A2 - antagonists & inhibitors Thromboxane A2 - biosynthesis Thromboxane A2 - physiology Uterus - blood supply
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