Loss of flow-mediated endothelium-dependent dilation occurs early in the development of atherosclerosis

Healthy arteries exhibit endothelium-dependent dilation in response to both local acetylcholine and increased blood flow. In humans, clinically overt coronary artery disease is characterized by loss of dilation to both acetylcholine and blood flow. The temporal relation, however, between functional...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1991-09, Vol.84 (3), p.1273-1278
Hauptverfasser:	McLenachan, J M, Williams, J K, Fish, R D, Ganz, P, Selwyn, A P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Arteriosclerosis - diagnostic imaging Arteriosclerosis - physiopathology Cholesterol, Dietary - administration & dosage Endothelium, Vascular - physiology Iliac Artery - diagnostic imaging Iliac Artery - physiology Macaca fascicularis Radiography Regional Blood Flow - physiology Time Factors Vasodilation - drug effects Vasodilation - physiology
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