Successful management of intractable cryptosporidial diarrhea with intravenous octreotide, a somatostatin analogue
A 38-year-old man with AIDS and intractable large-volume diarrhea due to a cryptosporidial infection was successfully treated with intravenous octreotide, a somatostatin analogue. The volume of diarrhea, 10-12 liters with 8-13 movements per day, was reduced to three to four semi-formed to formed sto...
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| Veröffentlicht in: | AIDS (London) 1991-06, Vol.5 (6), p.765-767 |
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| container_end_page | 767 |
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| container_issue | 6 |
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| container_title | AIDS (London) |
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| creator | KREINIK, G BURSTEIN, O LANDOR, M BERNSTEIN, L WEISS, L. M WITTNER, M |
| description | A 38-year-old man with AIDS and intractable large-volume diarrhea due to a cryptosporidial infection was successfully treated with intravenous octreotide, a somatostatin analogue. The volume of diarrhea, 10-12 liters with 8-13 movements per day, was reduced to three to four semi-formed to formed stools per day when the patient was treated with 400 micrograms intravenous octreotide daily. The patient's intravenous hyperalimentation was discontinued and he returned to oral feeding. He quickly regained his normal weight and has now resumed his normal activities. For those patients who cannot tolerate subcutaneous administration, intravenous octreotide therapy may not only be life-saving but may also markedly increase the quality of life. Roxithromycin, a macrolide antibiotic, was also administered to this patient with cryptosporidiosis but efficacy was not demonstrated. |
| doi_str_mv | 10.1097/00002030-199106000-00020 |
| format | Article |
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Roxithromycin, a macrolide antibiotic, was also administered to this patient with cryptosporidiosis but efficacy was not demonstrated.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/00002030-199106000-00020</identifier><identifier>PMID: 1883548</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Acquired Immunodeficiency Syndrome - complications ; Adult ; AIDS/HIV ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal agents ; Biological and medical sciences ; Cryptosporidiosis - complications ; Cryptosporidiosis - drug therapy ; Diarrhea - complications ; Diarrhea - drug therapy ; Humans ; Injections, Intravenous ; Male ; Medical sciences ; Octreotide - administration & dosage ; Octreotide - therapeutic use ; Pharmacology. 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M</creatorcontrib><creatorcontrib>WITTNER, M</creatorcontrib><title>Successful management of intractable cryptosporidial diarrhea with intravenous octreotide, a somatostatin analogue</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>A 38-year-old man with AIDS and intractable large-volume diarrhea due to a cryptosporidial infection was successfully treated with intravenous octreotide, a somatostatin analogue. The volume of diarrhea, 10-12 liters with 8-13 movements per day, was reduced to three to four semi-formed to formed stools per day when the patient was treated with 400 micrograms intravenous octreotide daily. The patient's intravenous hyperalimentation was discontinued and he returned to oral feeding. He quickly regained his normal weight and has now resumed his normal activities. For those patients who cannot tolerate subcutaneous administration, intravenous octreotide therapy may not only be life-saving but may also markedly increase the quality of life. Roxithromycin, a macrolide antibiotic, was also administered to this patient with cryptosporidiosis but efficacy was not demonstrated.</description><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Biological and medical sciences</subject><subject>Cryptosporidiosis - complications</subject><subject>Cryptosporidiosis - drug therapy</subject><subject>Diarrhea - complications</subject><subject>Diarrhea - drug therapy</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Octreotide - administration & dosage</subject><subject>Octreotide - therapeutic use</subject><subject>Pharmacology. 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M ; WITTNER, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-4c69c6630352791e2ad129f33e4a31f19dfbd66897d438527ece788e1ee16f333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Acquired Immunodeficiency Syndrome - complications</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal agents</topic><topic>Biological and medical sciences</topic><topic>Cryptosporidiosis - complications</topic><topic>Cryptosporidiosis - drug therapy</topic><topic>Diarrhea - complications</topic><topic>Diarrhea - drug therapy</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Octreotide - administration & dosage</topic><topic>Octreotide - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Roxithromycin - administration & dosage</topic><topic>Roxithromycin - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KREINIK, G</creatorcontrib><creatorcontrib>BURSTEIN, O</creatorcontrib><creatorcontrib>LANDOR, M</creatorcontrib><creatorcontrib>BERNSTEIN, L</creatorcontrib><creatorcontrib>WEISS, L. 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M</au><au>WITTNER, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful management of intractable cryptosporidial diarrhea with intravenous octreotide, a somatostatin analogue</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>1991-06-01</date><risdate>1991</risdate><volume>5</volume><issue>6</issue><spage>765</spage><epage>767</epage><pages>765-767</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>A 38-year-old man with AIDS and intractable large-volume diarrhea due to a cryptosporidial infection was successfully treated with intravenous octreotide, a somatostatin analogue. The volume of diarrhea, 10-12 liters with 8-13 movements per day, was reduced to three to four semi-formed to formed stools per day when the patient was treated with 400 micrograms intravenous octreotide daily. The patient's intravenous hyperalimentation was discontinued and he returned to oral feeding. 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| fulltext | fulltext |
| identifier | ISSN: 0269-9370 |
| ispartof | AIDS (London), 1991-06, Vol.5 (6), p.765-767 |
| issn | 0269-9370 1473-5571 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72070573 |
| source | Journals@Ovid Ovid Autoload; MEDLINE |
| subjects | Acquired Immunodeficiency Syndrome - complications Adult AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Biological and medical sciences Cryptosporidiosis - complications Cryptosporidiosis - drug therapy Diarrhea - complications Diarrhea - drug therapy Humans Injections, Intravenous Male Medical sciences Octreotide - administration & dosage Octreotide - therapeutic use Pharmacology. Drug treatments Roxithromycin - administration & dosage Roxithromycin - therapeutic use |
| title | Successful management of intractable cryptosporidial diarrhea with intravenous octreotide, a somatostatin analogue |
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