Effects of Human Interleukin-6 on Megakaryocyte Development and Thrombocytopoiesis in Primates

Recombinant human interleukin-6 (IL-6) has previously been shown to increase platelet counts in mice and primates. To elucidate the mechanisms underlying this phenomenon, serial analyses were performed on megakaryocytes obtained from rhesus monkeys treated for 8 days with 30 μg/kg/d of recombinant h...

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Veröffentlicht in:	Blood 1991-09, Vol.78 (6), p.1467-1475
Hauptverfasser:	Stahl, Claire P., Zucker-Franklin, Dorothea, Evatt, Bruce L., Winton, Elliot F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Platelets - cytology Cell Differentiation - drug effects Cell physiology DNA - analysis Fundamental and applied biological sciences. Psychology Humans Interleukin-6 - pharmacology Macaca mulatta Megakaryocytes - chemistry Megakaryocytes - cytology Megakaryocytes - drug effects Megakaryocytes - ultrastructure Microscopy, Electron Molecular and cellular biology Platelet Count - drug effects Ploidies Recombinant Proteins - pharmacology Time Factors
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