Microstructural analysis of Salzmann's nodular degeneration by in vivo confocal microscopy

A 44‐year‐old man with symptoms of ocular irritation and corneal changes characteristic of Salzmann's nodular degeneration in the left eye was examined using in vivo confocal microscopy. In vivo confocal microscopy highlighted an irregularly shaped basal epithelium with foci of prominent nuclei...

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Veröffentlicht in:	Clinical & experimental ophthalmology 2002-10, Vol.30 (5), p.367-368
Hauptverfasser:	Ku, Judy YF, Grupcheva, Christina N, McGhee, Charles NJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult cornea Corneal Dystrophies, Hereditary - pathology Corneal Stroma - pathology Epithelium, Corneal - pathology Extracellular Matrix - pathology Humans in vivo confocal microscopy Male Microscopy, Confocal Salzmann's nodular degeneration
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container_title	Clinical & experimental ophthalmology
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creator	Ku, Judy YF Grupcheva, Christina N McGhee, Charles NJ
description	A 44‐year‐old man with symptoms of ocular irritation and corneal changes characteristic of Salzmann's nodular degeneration in the left eye was examined using in vivo confocal microscopy. In vivo confocal microscopy highlighted an irregularly shaped basal epithelium with foci of prominent nuclei, and disrupted anterior stromal architecture with increased reflectivity of extracellular matrix within the nodules. These observations were consistent with prior histopathological descriptions of Salzmann's nodular degeneration. In vivo confocal microscopy enhances the clinicopathological assessment of degenerative corneal diseases, such as Salzmann's nodular degeneration, without the need for biopsy.
doi_str_mv	10.1046/j.1442-9071.2002.00558.x
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In vivo confocal microscopy enhances the clinicopathological assessment of degenerative corneal diseases, such as Salzmann's nodular degeneration, without the need for biopsy.</description><subject>Adult</subject><subject>cornea</subject><subject>Corneal Dystrophies, Hereditary - pathology</subject><subject>Corneal Stroma - pathology</subject><subject>Epithelium, Corneal - pathology</subject><subject>Extracellular Matrix - pathology</subject><subject>Humans</subject><subject>in vivo confocal microscopy</subject><subject>Male</subject><subject>Microscopy, Confocal</subject><subject>Salzmann's nodular degeneration</subject><issn>1442-6404</issn><issn>1442-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v3CAQhlHUqpuk_QsRp_RkBzA2ttRLtErz2UTatlopF4QBR2xt2ICdrvvrg3dX6TUXGGneZ2b0AAAxSjGixdkqxZSSpEIMpwQhkiKU52W6OQCHb40P-7qgiM7AUQgrFFMkKz6BGSYEZ7igh-Dxh5Hehd4Psh-8aKGwoh2DCdA18Kdo_3XC2q8BWqeGVnio9JO22oveOAvrERoLX8yLg9LZxsnId9t50q3Hz-BjI9qgv-z_Y_D7-8Wv-VVy93B5PT-_SyRFpExkLnEpVVUplUlZ11gwnFNa1ixTlRSKMaEVji-LN8smtnStSlKWNCcFrlV2DE53c9fePQ869LwzQeq2FVa7IXBGUFFVtIjBchecLgxeN3ztTSf8yDHik1e-4pMyPunjk1e-9co3ET3Z7xjqTqv_4F5kDHzbBf6aVo_vHsznFw-xiHiyw03o9eYNF_4PL1jGcr68v-QVvl_e3iwYX2SvxweXPA</recordid><startdate>200210</startdate><enddate>200210</enddate><creator>Ku, Judy YF</creator><creator>Grupcheva, Christina N</creator><creator>McGhee, Charles NJ</creator><general>Blackwell Science Pty</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200210</creationdate><title>Microstructural analysis of Salzmann's nodular degeneration by in vivo confocal microscopy</title><author>Ku, Judy YF ; Grupcheva, Christina N ; McGhee, Charles NJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4028-c5c18cd99dd3ccbb1a715448b73d9cad77aed177a7213cf544ebd828845261bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>cornea</topic><topic>Corneal Dystrophies, Hereditary - pathology</topic><topic>Corneal Stroma - pathology</topic><topic>Epithelium, Corneal - pathology</topic><topic>Extracellular Matrix - pathology</topic><topic>Humans</topic><topic>in vivo confocal microscopy</topic><topic>Male</topic><topic>Microscopy, Confocal</topic><topic>Salzmann's nodular degeneration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ku, Judy YF</creatorcontrib><creatorcontrib>Grupcheva, Christina N</creatorcontrib><creatorcontrib>McGhee, Charles NJ</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical & experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ku, Judy YF</au><au>Grupcheva, Christina N</au><au>McGhee, Charles NJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microstructural analysis of Salzmann's nodular degeneration by in vivo confocal microscopy</atitle><jtitle>Clinical & experimental ophthalmology</jtitle><addtitle>Clin Exp Ophthalmol</addtitle><date>2002-10</date><risdate>2002</risdate><volume>30</volume><issue>5</issue><spage>367</spage><epage>368</epage><pages>367-368</pages><issn>1442-6404</issn><eissn>1442-9071</eissn><abstract>A 44‐year‐old man with symptoms of ocular irritation and corneal changes characteristic of Salzmann's nodular degeneration in the left eye was examined using in vivo confocal microscopy. In vivo confocal microscopy highlighted an irregularly shaped basal epithelium with foci of prominent nuclei, and disrupted anterior stromal architecture with increased reflectivity of extracellular matrix within the nodules. These observations were consistent with prior histopathological descriptions of Salzmann's nodular degeneration. In vivo confocal microscopy enhances the clinicopathological assessment of degenerative corneal diseases, such as Salzmann's nodular degeneration, without the need for biopsy.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Pty</pub><pmid>12213164</pmid><doi>10.1046/j.1442-9071.2002.00558.x</doi><tpages>2</tpages></addata></record>
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subjects	Adult cornea Corneal Dystrophies, Hereditary - pathology Corneal Stroma - pathology Epithelium, Corneal - pathology Extracellular Matrix - pathology Humans in vivo confocal microscopy Male Microscopy, Confocal Salzmann's nodular degeneration
title	Microstructural analysis of Salzmann's nodular degeneration by in vivo confocal microscopy
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