2-Substituted 4-(Thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase

Steroid sulfatase (STS) has emerged as a highly attractive target for the therapy of a number of disorders. Starting with the known inhibitor estrone sulfamate (1) as lead compound and with the finding that steroid sulfamates containing a nonaromatic A-ring are inactive, chromen-4-one sulfamates wer...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 2002-09, Vol.45 (19), p.4310-4320
Hauptverfasser:	Nussbaumer, Peter, Lehr, Philipp, Billich, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - analogs & derivatives Adamantane - chemical synthesis Adamantane - chemistry Adamantane - pharmacology Analytical, structural and metabolic biochemistry Animals Arylsulfatases - antagonists & inhibitors Biological and medical sciences CHO Cells Cricetinae Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzymes and enzyme inhibitors Female Fundamental and applied biological sciences. Psychology Humans Hydrolases Kinetics Medical sciences Microsomes - drug effects Microsomes - enzymology Miscellaneous Pharmacology. Drug treatments Placenta - ultrastructure Steryl-Sulfatase Structure-Activity Relationship Sulfonic Acids - chemical synthesis Sulfonic Acids - chemistry Sulfonic Acids - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!