[Ala1,3,11,15]endothelin-1 analogs with ETB agonistic activity

A linear peptide analog of endothelin (ET)-1, [Ala1,3,11,15]ET-1 (4AlaET-1), and its truncated peptide analogs were synthesized to study the structural requirements of ET-1 for the recognition of ETs-nonselective ETB receptors. ET-1 exhibited sub-nanomolar binding to two distinct ET receptor subtype...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 1991-08, Vol.179 (1), p.286-292
Hauptverfasser:	SAEKI, T, IHARA, M, FUKURODA, T, YAMAGIWA, M, YANO, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animals Aorta - metabolism Binding, Competitive Biological and medical sciences Cell Membrane - metabolism Cerebellum - metabolism Endothelins - chemical synthesis Endothelins - metabolism Endothelins - pharmacology Fundamental and applied biological sciences. Psychology In Vitro Techniques Kinetics Molecular Sequence Data Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - physiology Peptides, Cyclic - chemical synthesis Peptides, Cyclic - metabolism Peptides, Cyclic - pharmacology Proteins Pulmonary Artery - drug effects Pulmonary Artery - physiology Receptors, Cell Surface - drug effects Receptors, Cell Surface - metabolism Receptors, Endothelin Structure-Activity Relationship Swine Vasodilation - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!