Dopamine antagonists during parturition disrupt maternal care and the retention of maternal behavior in rats
Brief contact with pups at parturition enables the female rat to establish and retain the full repertoire of maternal behaviors, allowing her to respond rapidly to pups in the future. To determine whether the dopamine system is involved in the retention of maternal behavior, females were continuousl...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 2002-11, Vol.73 (4), p.869-875 |
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| container_title | Pharmacology, biochemistry and behavior |
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| creator | Byrnes, Elizabeth M. Rigero, Beth A. Bridges, Robert S. |
| description | Brief contact with pups at parturition enables the female rat to establish and retain the full repertoire of maternal behaviors, allowing her to respond rapidly to pups in the future. To determine whether the dopamine system is involved in the retention of maternal behavior, females were continuously infused with dopamine antagonists during the periparturitional period and then allowed either a brief interaction period with pups (3 h) or no interaction with pups (pups removed as they were born). Females were exposed to either the D1-like antagonist SCH 23390 (0.1 or 1.0 mg/kg/day) or the D2-like antagonist clebopride (0.5 or 1.0 mg/kg/day). The high dose of either DA antagonist resulted in significant attenuation of maternal care immediately postpartum. When tested for the retention of maternal behavior 7 days later, however, only the females exposed to the D2 antagonist displayed a delayed response to shown full maternal behavior (FMB) towards donor pups. Thus, while both dopamine receptor subtypes appear necessary for the full and rapid expression of maternal behavior during the early postpartum period, only the D2 receptor subtype appears to be involved in the retention of this behavior. |
| doi_str_mv | 10.1016/S0091-3057(02)00941-3 |
| format | Article |
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Psychophysiology ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine D1 - agonists ; Receptors, Dopamine D1 - antagonists & inhibitors ; Receptors, Dopamine D1 - physiology ; Receptors, Dopamine D2 - agonists ; Receptors, Dopamine D2 - physiology ; Retention (Psychology) - drug effects ; Retention (Psychology) - physiology</subject><ispartof>Pharmacology, biochemistry and behavior, 2002-11, Vol.73 (4), p.869-875</ispartof><rights>2002 Elsevier Science Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-ace88c88bce726bdba82bb639030d321e1bcae849cb6ae8075bc7060e79871683</citedby><cites>FETCH-LOGICAL-c488t-ace88c88bce726bdba82bb639030d321e1bcae849cb6ae8075bc7060e79871683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0091-3057(02)00941-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13953432$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12213533$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Byrnes, Elizabeth M.</creatorcontrib><creatorcontrib>Rigero, Beth A.</creatorcontrib><creatorcontrib>Bridges, Robert S.</creatorcontrib><title>Dopamine antagonists during parturition disrupt maternal care and the retention of maternal behavior in rats</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Brief contact with pups at parturition enables the female rat to establish and retain the full repertoire of maternal behaviors, allowing her to respond rapidly to pups in the future. To determine whether the dopamine system is involved in the retention of maternal behavior, females were continuously infused with dopamine antagonists during the periparturitional period and then allowed either a brief interaction period with pups (3 h) or no interaction with pups (pups removed as they were born). Females were exposed to either the D1-like antagonist SCH 23390 (0.1 or 1.0 mg/kg/day) or the D2-like antagonist clebopride (0.5 or 1.0 mg/kg/day). The high dose of either DA antagonist resulted in significant attenuation of maternal care immediately postpartum. When tested for the retention of maternal behavior 7 days later, however, only the females exposed to the D2 antagonist displayed a delayed response to shown full maternal behavior (FMB) towards donor pups. Thus, while both dopamine receptor subtypes appear necessary for the full and rapid expression of maternal behavior during the early postpartum period, only the D2 receptor subtype appears to be involved in the retention of this behavior.</description><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Dopamine antagonist</subject><subject>Dopamine Antagonists - pharmacology</subject><subject>Dopamine D2 Receptor Antagonists</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Maternal behavior</subject><subject>Maternal Behavior - drug effects</subject><subject>Maternal Behavior - physiology</subject><subject>Maternal Behavior - psychology</subject><subject>Maternal retention</subject><subject>Neurotransmission and behavior</subject><subject>Parturition</subject><subject>Parturition - drug effects</subject><subject>Parturition - physiology</subject><subject>Parturition - psychology</subject><subject>Pregnancy</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Dopamine D1 - agonists</subject><subject>Receptors, Dopamine D1 - antagonists & inhibitors</subject><subject>Receptors, Dopamine D1 - physiology</subject><subject>Receptors, Dopamine D2 - agonists</subject><subject>Receptors, Dopamine D2 - physiology</subject><subject>Retention (Psychology) - drug effects</subject><subject>Retention (Psychology) - physiology</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0ctu1TAQBmALgeih8Aggb0CwSPElsZ0VQgXaSpVYAGtr7MxpjRIn2E4l3h6fizjLrsYjfWNb8xPymrMLzrj6-IOxnjeSdfo9Ex9q09buCdlwo2XTca2fks1_ckZe5PybMdYKpZ-TMy4El52UGzJ-mReYQkQKscDdHEMumQ5rCvGOLpBKPZUwRzqEnNal0AkKpggj9ZB2QwMt90gTFox7N29PxOE9PIQ50RBpgpJfkmdbGDO-OtZz8uvb15-X183t96uby8-3jW-NKQ14NMYb4zxqodzgwAjnlOyZZIMUHLnzgKbtvVO1Mt05r5liqHujuTLynLw73Luk-c-KudgpZI_jCBHnNVstmNLKPA65UaJVmlXYHaBPc84Jt3ZJYYL013Jmd3nYfR52t2zLhN3nYWWde3N8YHUTDqepYwAVvD0CyB7GbYLoQz452XeylaK6TweHdW8PAZPNPmD0OISEvthhDo985R8pXKjt</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>Byrnes, Elizabeth M.</creator><creator>Rigero, Beth A.</creator><creator>Bridges, Robert S.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>Dopamine antagonists during parturition disrupt maternal care and the retention of maternal behavior in rats</title><author>Byrnes, Elizabeth M. ; Rigero, Beth A. ; Bridges, Robert S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-ace88c88bce726bdba82bb639030d321e1bcae849cb6ae8075bc7060e79871683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Dopamine antagonist</topic><topic>Dopamine Antagonists - pharmacology</topic><topic>Dopamine D2 Receptor Antagonists</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Maternal behavior</topic><topic>Maternal Behavior - drug effects</topic><topic>Maternal Behavior - physiology</topic><topic>Maternal Behavior - psychology</topic><topic>Maternal retention</topic><topic>Neurotransmission and behavior</topic><topic>Parturition</topic><topic>Parturition - drug effects</topic><topic>Parturition - physiology</topic><topic>Parturition - psychology</topic><topic>Pregnancy</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Dopamine D1 - agonists</topic><topic>Receptors, Dopamine D1 - antagonists & inhibitors</topic><topic>Receptors, Dopamine D1 - physiology</topic><topic>Receptors, Dopamine D2 - agonists</topic><topic>Receptors, Dopamine D2 - physiology</topic><topic>Retention (Psychology) - drug effects</topic><topic>Retention (Psychology) - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Byrnes, Elizabeth M.</creatorcontrib><creatorcontrib>Rigero, Beth A.</creatorcontrib><creatorcontrib>Bridges, Robert S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Byrnes, Elizabeth M.</au><au>Rigero, Beth A.</au><au>Bridges, Robert S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dopamine antagonists during parturition disrupt maternal care and the retention of maternal behavior in rats</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>73</volume><issue>4</issue><spage>869</spage><epage>875</epage><pages>869-875</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Brief contact with pups at parturition enables the female rat to establish and retain the full repertoire of maternal behaviors, allowing her to respond rapidly to pups in the future. To determine whether the dopamine system is involved in the retention of maternal behavior, females were continuously infused with dopamine antagonists during the periparturitional period and then allowed either a brief interaction period with pups (3 h) or no interaction with pups (pups removed as they were born). Females were exposed to either the D1-like antagonist SCH 23390 (0.1 or 1.0 mg/kg/day) or the D2-like antagonist clebopride (0.5 or 1.0 mg/kg/day). The high dose of either DA antagonist resulted in significant attenuation of maternal care immediately postpartum. When tested for the retention of maternal behavior 7 days later, however, only the females exposed to the D2 antagonist displayed a delayed response to shown full maternal behavior (FMB) towards donor pups. Thus, while both dopamine receptor subtypes appear necessary for the full and rapid expression of maternal behavior during the early postpartum period, only the D2 receptor subtype appears to be involved in the retention of this behavior.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12213533</pmid><doi>10.1016/S0091-3057(02)00941-3</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Behavioral psychophysiology Biological and medical sciences Dopamine antagonist Dopamine Antagonists - pharmacology Dopamine D2 Receptor Antagonists Female Fundamental and applied biological sciences. Psychology Male Maternal behavior Maternal Behavior - drug effects Maternal Behavior - physiology Maternal Behavior - psychology Maternal retention Neurotransmission and behavior Parturition Parturition - drug effects Parturition - physiology Parturition - psychology Pregnancy Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Receptors, Dopamine D1 - agonists Receptors, Dopamine D1 - antagonists & inhibitors Receptors, Dopamine D1 - physiology Receptors, Dopamine D2 - agonists Receptors, Dopamine D2 - physiology Retention (Psychology) - drug effects Retention (Psychology) - physiology |
| title | Dopamine antagonists during parturition disrupt maternal care and the retention of maternal behavior in rats |
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