Time course of renal Na-K-ATPase, NHE3, NKCC2, NCC, and ENaC abundance changes with dietary NaCl restriction

We have used peptide-directed antibodies to each major renal Na transporter and channel proteins to screen renal homogenates for changes in Na transporter protein expression after initiation of dietary NaCl restriction. After equilibration on a NaCl-replete diet (2.0 meq. 200 g body wt(-1). day(-1))...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2002-10, Vol.283 (4), p.F648-F657
Hauptverfasser:	Masilamani, Shyama, Wang, Xiaoyan, Kim, Gheun-Ho, Brooks, Heddwen, Nielsen, Jakob, Nielsen, Soren, Nakamura, Kenzo, Stokes, John B, Knepper, Mark A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldosterone - blood Animals Blotting, Western Diet, Sodium-Restricted Epithelial Sodium Channels Kidney - enzymology Kidney - metabolism Male Nuclease Protection Assays Rats Rats, Sprague-Dawley RNA, Messenger - biosynthesis RNA, Messenger - genetics Sodium - urine Sodium Channels - biosynthesis Sodium Channels - genetics Sodium Chloride Symporters Sodium Chloride, Dietary Sodium-Hydrogen Exchanger 3 Sodium-Hydrogen Exchangers - biosynthesis Sodium-Hydrogen Exchangers - genetics Sodium-Potassium-Chloride Symporters - biosynthesis Sodium-Potassium-Chloride Symporters - genetics Sodium-Potassium-Exchanging ATPase - biosynthesis Sodium-Potassium-Exchanging ATPase - genetics Solute Carrier Family 12, Member 1 Symporters - biosynthesis Symporters - genetics
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