Solitary Expression of CD7 Among T-Cell Antigens in Acute Myeloid Leukemia: Identification of a Group of Patients With Similar T-Cell Receptor β and δ Rearrangements and Course of Disease Suggestive of Poor Prognosis

In a series of 100 acute myeloid leukemia (AML) patients defined by cytochemistry and immunophenotyping, 20 expressed T-lymphocyte associated antigens on the surface of their blasts. While 15 expressed two or more T-cell antigens, five were found to express only CD7. All patients belonged to the Fre...

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Veröffentlicht in:Blood 1991-09, Vol.78 (5), p.1292-1300
Hauptverfasser: Jensen, Arne W., Hokland, Marianne, Jorgensen, Hanne, Justesen, Just, Ellegaard, Jorgen, Hokland, Peter
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container_issue 5
container_start_page 1292
container_title Blood
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creator Jensen, Arne W.
Hokland, Marianne
Jorgensen, Hanne
Justesen, Just
Ellegaard, Jorgen
Hokland, Peter
description In a series of 100 acute myeloid leukemia (AML) patients defined by cytochemistry and immunophenotyping, 20 expressed T-lymphocyte associated antigens on the surface of their blasts. While 15 expressed two or more T-cell antigens, five were found to express only CD7. All patients belonged to the French-American-British type M4, and four were under the age of 40. Despite intensive chemotherapy, four never obtained a complete remission and the fifth died of relapse after an allogenic bone marrow transplantation. While 12 randomly selected T-cell antigen negative AML patients showed only few rearrangements in Igor T-cell receptor (TCR) genes, such genetic alterations were demonstrated in four of five patients for the TCR δ gene and in all patients for the TCR β gene. Interestingly, DNA fragments of similar size were demonstrated in three of five patients for both the β and δ genes. These data suggest that the solitary presence of CD7 among T-cell antigens in otherwise clearcut AML cases identifies a group of patients with similarities in antigen receptor gene configuration as well as outcome.
doi_str_mv 10.1182/blood.V78.5.1292.1292
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subjects Acute Disease
Antigens, CD - biosynthesis
Antigens, CD - genetics
Antigens, CD - immunology
Antigens, CD7
Antigens, Differentiation, T-Lymphocyte - biosynthesis
Antigens, Differentiation, T-Lymphocyte - genetics
Antigens, Differentiation, T-Lymphocyte - immunology
Biological and medical sciences
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor - immunology
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor - immunology
Gene Rearrangement, T-Lymphocyte - immunology
Hematologic and hematopoietic diseases
Humans
Immunophenotyping
Leukemia, Myeloid - genetics
Leukemia, Myeloid - immunology
Medical sciences
Remission Induction
title Solitary Expression of CD7 Among T-Cell Antigens in Acute Myeloid Leukemia: Identification of a Group of Patients With Similar T-Cell Receptor β and δ Rearrangements and Course of Disease Suggestive of Poor Prognosis
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