Transformed mammalian cells are deficient in kinase-mediated control of progression through the G1 phase of the cell cycle

To investigate the role of kinase-mediated mechanisms in regulating mammalian cell proliferation, we determined the effects of the general protein kinase inhibitor staurosporine on the proliferation of a series of nontransformed and transformed cultured rodent and human cells. Levels of staurosporin...

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