Pharmacokinetic differences of morphine and morphine-glucuronides are reflected in locomotor activity

The main metabolites of morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G), have been considered to participate in some of the effects of morphine. There is limited knowledge of the pharmacokinetics and dynamics of morphine and the main metabolites in mice, but mice are widely u...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2002-11, Vol.73 (4), p.883-892
Hauptverfasser:	Handal, Marte, Grung, Merete, Skurtveit, Svetlana, Ripel, Åse, Mørland, Jørg
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Biological and medical sciences Biological Availability Locomotor activity Male Medical sciences Mice Mice, Inbred C57BL Morphine Morphine - blood Morphine - pharmacokinetics Morphine - pharmacology Morphine Derivatives - blood Morphine Derivatives - pharmacokinetics Morphine Derivatives - pharmacology Morphine-3-glucuronide Morphine-6-glucuronide Motor Activity - drug effects Motor Activity - physiology Neuropharmacology Pharmacokinetics Pharmacology. Drug treatments
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