Expression of the CD2 Activation Epitope T11‐3 (CD2R) on T Cells in Rheumatoid Arthritis, Juvenile Rheumatoid Arthritis, Systemic Lupus Erythematosus, Ankylosing Spondylitis, and Lyme Disease: Phenotypic and Functional Analysis
CD2R is an activation‐associated epitope unmasked by a conformational change of the CD2 cell‐surface glycoprotein. In spite of elaborate studies on the role of CD2 and CD2R in adhesion and stimulation of T cells in vitro, no instances of CD2R expression in vivo were known to date. We report high lev...
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| Veröffentlicht in: | Scandinavian journal of immunology 1991-09, Vol.34 (3), p.351-358 |
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| creator | POTOCNIK, A. J. MENNINGER, H. YANG, S. Y. PIRNER, K. KRAUSE, A. BURMESTER, G. R. BRÖKER, B. M. HEPT, P. WESELOH, G. MICHELS, H. TRUCKENBRODT, H. EMMRICH, F. KROCZEK, R. A. |
| description | CD2R is an activation‐associated epitope unmasked by a conformational change of the CD2 cell‐surface glycoprotein. In spite of elaborate studies on the role of CD2 and CD2R in adhesion and stimulation of T cells in vitro, no instances of CD2R expression in vivo were known to date. We report high levels or CD2R observed on blood and synovial fluid T cells in rheumatoid arthritis and on peripheral blood T cells in juvenile rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, and Lyme disease. In vivo, expression of CD2R was restricted to T cells, not limited to a particular T‐cell subset and not correlated with the expression of p55 interleukin 2R (IL‐2R) (CD25) or major histocompatibility complex (MHC) class II molecules. When stimulated to prolieration via CD2 or CD3, ex vivo CD2R+ T cells showed the same basic activation requirements as CD2R‐ T cells. |
| doi_str_mv | 10.1111/j.1365-3083.1991.tb01556.x |
| format | Article |
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J. ; MENNINGER, H. ; YANG, S. Y. ; PIRNER, K. ; KRAUSE, A. ; BURMESTER, G. R. ; BRÖKER, B. M. ; HEPT, P. ; WESELOH, G. ; MICHELS, H. ; TRUCKENBRODT, H. ; EMMRICH, F. ; KROCZEK, R. A.</creator><creatorcontrib>POTOCNIK, A. J. ; MENNINGER, H. ; YANG, S. Y. ; PIRNER, K. ; KRAUSE, A. ; BURMESTER, G. R. ; BRÖKER, B. M. ; HEPT, P. ; WESELOH, G. ; MICHELS, H. ; TRUCKENBRODT, H. ; EMMRICH, F. ; KROCZEK, R. A.</creatorcontrib><description>CD2R is an activation‐associated epitope unmasked by a conformational change of the CD2 cell‐surface glycoprotein. In spite of elaborate studies on the role of CD2 and CD2R in adhesion and stimulation of T cells in vitro, no instances of CD2R expression in vivo were known to date. We report high levels or CD2R observed on blood and synovial fluid T cells in rheumatoid arthritis and on peripheral blood T cells in juvenile rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, and Lyme disease. In vivo, expression of CD2R was restricted to T cells, not limited to a particular T‐cell subset and not correlated with the expression of p55 interleukin 2R (IL‐2R) (CD25) or major histocompatibility complex (MHC) class II molecules. 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A.</creatorcontrib><title>Expression of the CD2 Activation Epitope T11‐3 (CD2R) on T Cells in Rheumatoid Arthritis, Juvenile Rheumatoid Arthritis, Systemic Lupus Erythematosus, Ankylosing Spondylitis, and Lyme Disease: Phenotypic and Functional Analysis</title><title>Scandinavian journal of immunology</title><addtitle>Scand J Immunol</addtitle><description>CD2R is an activation‐associated epitope unmasked by a conformational change of the CD2 cell‐surface glycoprotein. In spite of elaborate studies on the role of CD2 and CD2R in adhesion and stimulation of T cells in vitro, no instances of CD2R expression in vivo were known to date. We report high levels or CD2R observed on blood and synovial fluid T cells in rheumatoid arthritis and on peripheral blood T cells in juvenile rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, and Lyme disease. In vivo, expression of CD2R was restricted to T cells, not limited to a particular T‐cell subset and not correlated with the expression of p55 interleukin 2R (IL‐2R) (CD25) or major histocompatibility complex (MHC) class II molecules. When stimulated to prolieration via CD2 or CD3, ex vivo CD2R+ T cells showed the same basic activation requirements as CD2R‐ T cells.</description><subject>Antigens, Differentiation, T-Lymphocyte - physiology</subject><subject>Arthritis - genetics</subject><subject>Arthritis - immunology</subject><subject>Arthritis, Juvenile - immunology</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>CD2 Antigens</subject><subject>Epitopes - immunology</subject><subject>Humans</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Lyme Disease - immunology</subject><subject>Lymphocyte Activation</subject><subject>Phenotype</subject><subject>Receptors, Immunologic - physiology</subject><subject>Spondylitis, Ankylosing - immunology</subject><subject>T-Lymphocytes - immunology</subject><issn>0300-9475</issn><issn>1365-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkcGO0zAURSMEGsrAJyBZLBBIJNhxnMSzQKo6HZhRJdC0rC3XcalLYmfynKHZ8Ql8IxL_gaNUsGKBN5Z87r3PejeKXhCckHDeHhJCcxZTXNKEcE4Sv8WEsTw5Pohmf9DDaIYpxjHPCvY4egJwwJjQtKBn0RkpCMsxm0W_lse20wDGWeR2yO81WlymaK68uZd-fF22xrtWow0hP7__oOhV4LevUSAbtNB1DchYdLvXfSO9MxWad37fGW_gDbrp77U1tf4HXg_gdWMUWvVtD2jZDWH8KIM-0Ln9OtQOjP2C1q2z1VBPLmkrtBoajS4NaAn6An3aa-v80IakEV71Vo0_l3XIkPUABp5Gj3ayBv3sdJ9Hn6-Wm8WHePXx_fVivooV5ZTEOZec0SLLWJUV6ZZUmOEsr3BWUMmzihel4jjdlSrj6TaleSExVSXjO4JVpUtFz6OXU27bubtegxeNARWWJK12PYgixTljZRaEF5NQdQ6g0zvRdqaR3SAIFmPH4iDGIsVYpBg7FqeOxTGYn5-m9NtGV3-tU6mBv5v4t7D74T-SxfrmmjJCfwM7Crn0</recordid><startdate>199109</startdate><enddate>199109</enddate><creator>POTOCNIK, A. 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A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of the CD2 Activation Epitope T11‐3 (CD2R) on T Cells in Rheumatoid Arthritis, Juvenile Rheumatoid Arthritis, Systemic Lupus Erythematosus, Ankylosing Spondylitis, and Lyme Disease: Phenotypic and Functional Analysis</atitle><jtitle>Scandinavian journal of immunology</jtitle><addtitle>Scand J Immunol</addtitle><date>1991-09</date><risdate>1991</risdate><volume>34</volume><issue>3</issue><spage>351</spage><epage>358</epage><pages>351-358</pages><issn>0300-9475</issn><eissn>1365-3083</eissn><abstract>CD2R is an activation‐associated epitope unmasked by a conformational change of the CD2 cell‐surface glycoprotein. In spite of elaborate studies on the role of CD2 and CD2R in adhesion and stimulation of T cells in vitro, no instances of CD2R expression in vivo were known to date. We report high levels or CD2R observed on blood and synovial fluid T cells in rheumatoid arthritis and on peripheral blood T cells in juvenile rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, and Lyme disease. In vivo, expression of CD2R was restricted to T cells, not limited to a particular T‐cell subset and not correlated with the expression of p55 interleukin 2R (IL‐2R) (CD25) or major histocompatibility complex (MHC) class II molecules. When stimulated to prolieration via CD2 or CD3, ex vivo CD2R+ T cells showed the same basic activation requirements as CD2R‐ T cells.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>1715605</pmid><doi>10.1111/j.1365-3083.1991.tb01556.x</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0300-9475 |
| ispartof | Scandinavian journal of immunology, 1991-09, Vol.34 (3), p.351-358 |
| issn | 0300-9475 1365-3083 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Antigens, Differentiation, T-Lymphocyte - physiology Arthritis - genetics Arthritis - immunology Arthritis, Juvenile - immunology Arthritis, Rheumatoid - immunology CD2 Antigens Epitopes - immunology Humans Lupus Erythematosus, Systemic - immunology Lyme Disease - immunology Lymphocyte Activation Phenotype Receptors, Immunologic - physiology Spondylitis, Ankylosing - immunology T-Lymphocytes - immunology |
| title | Expression of the CD2 Activation Epitope T11‐3 (CD2R) on T Cells in Rheumatoid Arthritis, Juvenile Rheumatoid Arthritis, Systemic Lupus Erythematosus, Ankylosing Spondylitis, and Lyme Disease: Phenotypic and Functional Analysis |
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