Towards a high-affinity allosteric enhancer at muscarinic M1 receptors

Loss of forebrain acetylcholine (ACh) is an early neurochemical lesion in Alzheimer's Disease (AD), and muscarinic receptors for ACh are involved in memory and cognition, so a muscarinic agonist could provide 'replacement therapy' in this disease. Muscarinic receptors, which couple to...

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of molecular neuroscience 2002-08, Vol.19 (1-2), p.123-127
Hauptverfasser:	Lazareno, Sebastian, Popham, Angela, Birdsall, Nigel J M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Allosteric Regulation Allosteric Site - drug effects Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Animals Cerebral Cortex - metabolism Cerebral Cortex - physiopathology CHO Cells Cricetinae Hippocampus - metabolism Hippocampus - physiopathology Humans Muscarinic Agonists - chemical synthesis Muscarinic Agonists - therapeutic use Radioligand Assay Receptor, Muscarinic M1 Receptors, Muscarinic - drug effects Receptors, Muscarinic - metabolism
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