Effects of chronic dysthyroidism on activity and exploration
The aim of the present study was to determine the influence of thyroid function on the activity and exploratory behaviour of male Wistar rats. Dysthyroidism was induced by adding drugs to their drinking water from the ninth day of gestation. This method is not as stressful as daily thyroxine injecti...
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| Veröffentlicht in: | Physiology & behavior 2002-09, Vol.77 (1), p.125-133 |
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| creator | Sala-Roca, Josefina Martı́-Carbonell, Maria Assumpció Garau, Adriana Darbra, Sonia Balada, Ferran |
| description | The aim of the present study was to determine the influence of thyroid function on the activity and exploratory behaviour of male Wistar rats. Dysthyroidism was induced by adding drugs to their drinking water from the ninth day of gestation. This method is not as stressful as daily thyroxine injections or thyroidectomy, and therefore did not affect the analysed behavioural patterns. After weaning, the drugs were administered to the young rats until the end of the experiment. Activity and exploration were measured using the Boissier test, a light–darkness test and an open-field test when they were 77 days old. In order to verify that the animals' motor capacity had not been impaired, a psychomotor battery was used. Chronic hyperthyroidism produced a significant increase in activity, but did not affect exploration. On the other hand, hypothyroidism did not affect activity, but did increase exploration. This increase in exploration was observed in activity-independent behavioural parameters, such as head dipping and glancing. |
| doi_str_mv | 10.1016/S0031-9384(02)00815-6 |
| format | Article |
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Dysthyroidism was induced by adding drugs to their drinking water from the ninth day of gestation. This method is not as stressful as daily thyroxine injections or thyroidectomy, and therefore did not affect the analysed behavioural patterns. After weaning, the drugs were administered to the young rats until the end of the experiment. Activity and exploration were measured using the Boissier test, a light–darkness test and an open-field test when they were 77 days old. In order to verify that the animals' motor capacity had not been impaired, a psychomotor battery was used. Chronic hyperthyroidism produced a significant increase in activity, but did not affect exploration. On the other hand, hypothyroidism did not affect activity, but did increase exploration. 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Dysthyroidism was induced by adding drugs to their drinking water from the ninth day of gestation. This method is not as stressful as daily thyroxine injections or thyroidectomy, and therefore did not affect the analysed behavioural patterns. After weaning, the drugs were administered to the young rats until the end of the experiment. Activity and exploration were measured using the Boissier test, a light–darkness test and an open-field test when they were 77 days old. In order to verify that the animals' motor capacity had not been impaired, a psychomotor battery was used. Chronic hyperthyroidism produced a significant increase in activity, but did not affect exploration. On the other hand, hypothyroidism did not affect activity, but did increase exploration. This increase in exploration was observed in activity-independent behavioural parameters, such as head dipping and glancing.</description><subject>Activity</subject><subject>Anatomical correlates of behavior</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Exploration</subject><subject>Exploratory Behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hyperthyroidism</subject><subject>Hyperthyroidism - blood</subject><subject>Hyperthyroidism - physiopathology</subject><subject>Hyperthyroidism - psychology</subject><subject>Hypothyroidism</subject><subject>Hypothyroidism - blood</subject><subject>Hypothyroidism - physiopathology</subject><subject>Hypothyroidism - psychology</subject><subject>Male</subject><subject>Methimazole</subject><subject>Motor Activity</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. 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| subjects | Activity Anatomical correlates of behavior Animals Behavioral psychophysiology Biological and medical sciences Chronic Disease Exploration Exploratory Behavior Female Fundamental and applied biological sciences. Psychology Hyperthyroidism Hyperthyroidism - blood Hyperthyroidism - physiopathology Hyperthyroidism - psychology Hypothyroidism Hypothyroidism - blood Hypothyroidism - physiopathology Hypothyroidism - psychology Male Methimazole Motor Activity Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rat Rats Rats, Wistar Thyroxine Thyroxine - blood |
| title | Effects of chronic dysthyroidism on activity and exploration |
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