Two for two: Cdk2 and its role in centrosome doubling

The magic number in cell division is two: during S phase the cell makes two copies of its genome, and during mitosis the equal segregation of all sister chromosomes to the two daughter cell critically depends upon the formation of a bipolar mitotic spindle. Since spindle polarity in higher animal ce...

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Veröffentlicht in:	Oncogene 2002-09, Vol.21 (40), p.6154-6160
Hauptverfasser:	Hinchcliffe, Edward H, Sluder, Greenfield
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer CDC2-CDC28 Kinases Cell cycle Cell division Centrosome Cyclin E - physiology Cyclin-Dependent Kinase 2 Cyclin-Dependent Kinases - metabolism Cyclin-Dependent Kinases - physiology Humans Kinases Protein synthesis Protein-Serine-Threonine Kinases - metabolism Protein-Serine-Threonine Kinases - physiology
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