A Comparison of Parathyroid-Gland Function in Haemodialysis Patients with Different Forms of Renal Osteodystrophy
Parathyroid function was studied in three different histological forms of renal osteodystrophy: osteitis fibrosa (OF), low-turnover aluminium-associated bone disease (LTAABD), and aplastic bone disease without aluminium (ABD). Parathyroid function was determined by the evaluation of the sigmoidal pa...
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| Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 1991, Vol.6 (4), p.244-251 |
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| creator | Felsenfeld, A. J. Rodriguez, M. Dunlay, R. Llach, F. |
| description | Parathyroid function was studied in three different histological forms of renal osteodystrophy: osteitis fibrosa (OF), low-turnover aluminium-associated bone disease (LTAABD), and aplastic bone disease without aluminium (ABD). Parathyroid function was determined by the evaluation of the sigmoidal parathyroid hormone-(PTH)-calcium curve, which was obtained by the performance of a reduced calcium and an increased calcium haemodialysis. Parameters of the sigmoidal PTH-calcium curve evaluated included maximally stimulated (PTHMax) and inhibited (PTHMin) PTH, the set point of calcium for PTH (ICA50), defined as the ionised calcium concentration at which PTHMax was reduced by 50%, the ratio of basal PTH to maximally stimulated PTH (PTHBase:PTHMax), the ionised calcium concentration at which basal (ICABase), maximally stimulated (ICAMax), and maximally inhibited (ICAMin) PTH values were observed, and the slope of the PTH-calcium curve. Both PTHMax and PTHMin, were greater in OF than the other two groups (P |
| doi_str_mv | 10.1093/ndt/6.4.244 |
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J. ; Rodriguez, M. ; Dunlay, R. ; Llach, F.</creator><creatorcontrib>Felsenfeld, A. J. ; Rodriguez, M. ; Dunlay, R. ; Llach, F.</creatorcontrib><description>Parathyroid function was studied in three different histological forms of renal osteodystrophy: osteitis fibrosa (OF), low-turnover aluminium-associated bone disease (LTAABD), and aplastic bone disease without aluminium (ABD). Parathyroid function was determined by the evaluation of the sigmoidal parathyroid hormone-(PTH)-calcium curve, which was obtained by the performance of a reduced calcium and an increased calcium haemodialysis. Parameters of the sigmoidal PTH-calcium curve evaluated included maximally stimulated (PTHMax) and inhibited (PTHMin) PTH, the set point of calcium for PTH (ICA50), defined as the ionised calcium concentration at which PTHMax was reduced by 50%, the ratio of basal PTH to maximally stimulated PTH (PTHBase:PTHMax), the ionised calcium concentration at which basal (ICABase), maximally stimulated (ICAMax), and maximally inhibited (ICAMin) PTH values were observed, and the slope of the PTH-calcium curve. Both PTHMax and PTHMin, were greater in OF than the other two groups (P<0.02). The ratio of basal to maximally stimulated PTH was greater (P<0.02) in OF (61±7%) than LTAABD (33±5%) and ABD (36±7%). The ICA50 and the ICAMax were greater (P<0.03) in OF than the other two groups; however, no differences were observed in the ICABaSe and ICAMin. The slope of the PTH-calcium curve (% maximal PTH), which should indicate the sensitivity of parathyroid cells, was greater in OF than LTAABD (P<0.04). No differences in the PTH-calcium curve were observed between LTAABD and ABD. An additional finding was a significant correlation between PTHMin and PTHMax (r=0.93), and PTHBase and PTHMax (r=0.87), overall, and within each of the three individual groups. In conclusion (1) the linear correlation between PTHMin and PTHMax suggests that these parameters may reflect parathyroid gland mass; (2) parathyroid function was similar in LTAABD and ABD; and (3) in osteitis fibrosa: (a) the greater PTHBase:PTHMax ratio indicates increased basal stimulation of PTH secretion; (b) the greater ICA50 and ICAMax indicates a shift of the PTH-calcium, curve to the right; and (c) the steeper slope of the PTH-calcium curve (OF versus LTAABD) indicates that the sensitivity of parathyroid cells was enhanced.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/6.4.244</identifier><identifier>PMID: 1881578</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Aluminum - metabolism ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Calcium ; Calcium - blood ; Chronic Kidney Disease-Mineral and Bone Disorder - classification ; Chronic Kidney Disease-Mineral and Bone Disorder - pathology ; Chronic Kidney Disease-Mineral and Bone Disorder - physiopathology ; Emergency and intensive care: renal failure. Dialysis management ; Humans ; Intensive care medicine ; Medical sciences ; Parathyroid function ; Parathyroid Glands - pathology ; Parathyroid Glands - physiopathology ; Parathyroid hormone ; Parathyroid Hormone - blood ; Renal Dialysis ; Renal osteodystrophy ; Sensitivity of parathyroid cells ; Set point of calcium</subject><ispartof>Nephrology, dialysis, transplantation, 1991, Vol.6 (4), p.244-251</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c267t-5541627a676aa24f039f7cd08f936c7218ef0c6286fa8beec7bc0f019f7930253</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19738721$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1881578$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Felsenfeld, A. J.</creatorcontrib><creatorcontrib>Rodriguez, M.</creatorcontrib><creatorcontrib>Dunlay, R.</creatorcontrib><creatorcontrib>Llach, F.</creatorcontrib><title>A Comparison of Parathyroid-Gland Function in Haemodialysis Patients with Different Forms of Renal Osteodystrophy</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol Dial Transplant</addtitle><description>Parathyroid function was studied in three different histological forms of renal osteodystrophy: osteitis fibrosa (OF), low-turnover aluminium-associated bone disease (LTAABD), and aplastic bone disease without aluminium (ABD). Parathyroid function was determined by the evaluation of the sigmoidal parathyroid hormone-(PTH)-calcium curve, which was obtained by the performance of a reduced calcium and an increased calcium haemodialysis. Parameters of the sigmoidal PTH-calcium curve evaluated included maximally stimulated (PTHMax) and inhibited (PTHMin) PTH, the set point of calcium for PTH (ICA50), defined as the ionised calcium concentration at which PTHMax was reduced by 50%, the ratio of basal PTH to maximally stimulated PTH (PTHBase:PTHMax), the ionised calcium concentration at which basal (ICABase), maximally stimulated (ICAMax), and maximally inhibited (ICAMin) PTH values were observed, and the slope of the PTH-calcium curve. Both PTHMax and PTHMin, were greater in OF than the other two groups (P<0.02). The ratio of basal to maximally stimulated PTH was greater (P<0.02) in OF (61±7%) than LTAABD (33±5%) and ABD (36±7%). The ICA50 and the ICAMax were greater (P<0.03) in OF than the other two groups; however, no differences were observed in the ICABaSe and ICAMin. The slope of the PTH-calcium curve (% maximal PTH), which should indicate the sensitivity of parathyroid cells, was greater in OF than LTAABD (P<0.04). No differences in the PTH-calcium curve were observed between LTAABD and ABD. An additional finding was a significant correlation between PTHMin and PTHMax (r=0.93), and PTHBase and PTHMax (r=0.87), overall, and within each of the three individual groups. In conclusion (1) the linear correlation between PTHMin and PTHMax suggests that these parameters may reflect parathyroid gland mass; (2) parathyroid function was similar in LTAABD and ABD; and (3) in osteitis fibrosa: (a) the greater PTHBase:PTHMax ratio indicates increased basal stimulation of PTH secretion; (b) the greater ICA50 and ICAMax indicates a shift of the PTH-calcium, curve to the right; and (c) the steeper slope of the PTH-calcium curve (OF versus LTAABD) indicates that the sensitivity of parathyroid cells was enhanced.</description><subject>Aluminum - metabolism</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Calcium</subject><subject>Calcium - blood</subject><subject>Chronic Kidney Disease-Mineral and Bone Disorder - classification</subject><subject>Chronic Kidney Disease-Mineral and Bone Disorder - pathology</subject><subject>Chronic Kidney Disease-Mineral and Bone Disorder - physiopathology</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Medical sciences</subject><subject>Parathyroid function</subject><subject>Parathyroid Glands - pathology</subject><subject>Parathyroid Glands - physiopathology</subject><subject>Parathyroid hormone</subject><subject>Parathyroid Hormone - blood</subject><subject>Renal Dialysis</subject><subject>Renal osteodystrophy</subject><subject>Sensitivity of parathyroid cells</subject><subject>Set point of calcium</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9r2zAcR8VY6bKup50HumyX4lQ_bEk-lmxpRgMdpRulF6HIEtFmW6m-Cqv_-6kkrCch3uOD9BD6SMmckpZfjl2-FPN6zur6DZrRWpCKcdW8RbNCaUUa0r5D7wF-E0JaJuUpOqVK0UaqGXq6wos47EwKEEccPf5hksnbKcXQVde9GTu83I82h0LDiFfGDbELpp8gQHFzcGMG_DfkLf4avHep3PEypgFexu7caHp8C9nFboKc4m47fUAn3vTgzo_nGfq5_Ha_WFXr2-vvi6t1ZZmQuWqamgomjZDCGFZ7wlsvbUeUb7mwklHlPLGCKeGN2jhn5cYST2ixWk5Yw8_Ql8PuLsWnvYOshwDW9eVPLu5BS0YEL0GKeHEQbYoAyXm9S2EwadKU6JfAugTWQte6BC72p-PsfjO47tU9FC3885EbsKb3yYw2wKvWSq7K64tXHbxQ6jz_5yb90UJy2ejVw6O-u5H3v9biUSv-DwkGk_I</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>Felsenfeld, A. J.</creator><creator>Rodriguez, M.</creator><creator>Dunlay, R.</creator><creator>Llach, F.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1991</creationdate><title>A Comparison of Parathyroid-Gland Function in Haemodialysis Patients with Different Forms of Renal Osteodystrophy</title><author>Felsenfeld, A. J. ; Rodriguez, M. ; Dunlay, R. ; Llach, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c267t-5541627a676aa24f039f7cd08f936c7218ef0c6286fa8beec7bc0f019f7930253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Aluminum - metabolism</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Calcium</topic><topic>Calcium - blood</topic><topic>Chronic Kidney Disease-Mineral and Bone Disorder - classification</topic><topic>Chronic Kidney Disease-Mineral and Bone Disorder - pathology</topic><topic>Chronic Kidney Disease-Mineral and Bone Disorder - physiopathology</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Medical sciences</topic><topic>Parathyroid function</topic><topic>Parathyroid Glands - pathology</topic><topic>Parathyroid Glands - physiopathology</topic><topic>Parathyroid hormone</topic><topic>Parathyroid Hormone - blood</topic><topic>Renal Dialysis</topic><topic>Renal osteodystrophy</topic><topic>Sensitivity of parathyroid cells</topic><topic>Set point of calcium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Felsenfeld, A. J.</creatorcontrib><creatorcontrib>Rodriguez, M.</creatorcontrib><creatorcontrib>Dunlay, R.</creatorcontrib><creatorcontrib>Llach, F.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Felsenfeld, A. J.</au><au>Rodriguez, M.</au><au>Dunlay, R.</au><au>Llach, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Comparison of Parathyroid-Gland Function in Haemodialysis Patients with Different Forms of Renal Osteodystrophy</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol Dial Transplant</addtitle><date>1991</date><risdate>1991</risdate><volume>6</volume><issue>4</issue><spage>244</spage><epage>251</epage><pages>244-251</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>Parathyroid function was studied in three different histological forms of renal osteodystrophy: osteitis fibrosa (OF), low-turnover aluminium-associated bone disease (LTAABD), and aplastic bone disease without aluminium (ABD). Parathyroid function was determined by the evaluation of the sigmoidal parathyroid hormone-(PTH)-calcium curve, which was obtained by the performance of a reduced calcium and an increased calcium haemodialysis. Parameters of the sigmoidal PTH-calcium curve evaluated included maximally stimulated (PTHMax) and inhibited (PTHMin) PTH, the set point of calcium for PTH (ICA50), defined as the ionised calcium concentration at which PTHMax was reduced by 50%, the ratio of basal PTH to maximally stimulated PTH (PTHBase:PTHMax), the ionised calcium concentration at which basal (ICABase), maximally stimulated (ICAMax), and maximally inhibited (ICAMin) PTH values were observed, and the slope of the PTH-calcium curve. Both PTHMax and PTHMin, were greater in OF than the other two groups (P<0.02). The ratio of basal to maximally stimulated PTH was greater (P<0.02) in OF (61±7%) than LTAABD (33±5%) and ABD (36±7%). The ICA50 and the ICAMax were greater (P<0.03) in OF than the other two groups; however, no differences were observed in the ICABaSe and ICAMin. The slope of the PTH-calcium curve (% maximal PTH), which should indicate the sensitivity of parathyroid cells, was greater in OF than LTAABD (P<0.04). No differences in the PTH-calcium curve were observed between LTAABD and ABD. An additional finding was a significant correlation between PTHMin and PTHMax (r=0.93), and PTHBase and PTHMax (r=0.87), overall, and within each of the three individual groups. In conclusion (1) the linear correlation between PTHMin and PTHMax suggests that these parameters may reflect parathyroid gland mass; (2) parathyroid function was similar in LTAABD and ABD; and (3) in osteitis fibrosa: (a) the greater PTHBase:PTHMax ratio indicates increased basal stimulation of PTH secretion; (b) the greater ICA50 and ICAMax indicates a shift of the PTH-calcium, curve to the right; and (c) the steeper slope of the PTH-calcium curve (OF versus LTAABD) indicates that the sensitivity of parathyroid cells was enhanced.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>1881578</pmid><doi>10.1093/ndt/6.4.244</doi><tpages>8</tpages></addata></record> |
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| ispartof | Nephrology, dialysis, transplantation, 1991, Vol.6 (4), p.244-251 |
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| subjects | Aluminum - metabolism Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Calcium Calcium - blood Chronic Kidney Disease-Mineral and Bone Disorder - classification Chronic Kidney Disease-Mineral and Bone Disorder - pathology Chronic Kidney Disease-Mineral and Bone Disorder - physiopathology Emergency and intensive care: renal failure. Dialysis management Humans Intensive care medicine Medical sciences Parathyroid function Parathyroid Glands - pathology Parathyroid Glands - physiopathology Parathyroid hormone Parathyroid Hormone - blood Renal Dialysis Renal osteodystrophy Sensitivity of parathyroid cells Set point of calcium |
| title | A Comparison of Parathyroid-Gland Function in Haemodialysis Patients with Different Forms of Renal Osteodystrophy |
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