Acute, but not repeated, cocaine administration decreases renin secretion in the conscious male rat
The effects of cocaine on renin secretion have been addressed and a previously unreported inhibitory effect has been identified on this neuroendocrine system in the conscious male rat. Acute intraperitoneal administration of cocaine dose-dependently (1.5, 7.5, 15, and 30 mg/kg; at 15 min) produced a...
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| Veröffentlicht in: | Neuroscience letters 1991-06, Vol.127 (2), p.181-184 |
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| container_title | Neuroscience letters |
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| creator | Lakoski, Joan M. Rittenhouse, Peter A. Bonadonna, Anna M. Van de Kar, Louis D. |
| description | The effects of cocaine on renin secretion have been addressed and a previously unreported inhibitory effect has been identified on this neuroendocrine system in the conscious male rat. Acute intraperitoneal administration of cocaine dose-dependently (1.5, 7.5, 15, and 30 mg/kg; at 15 min) produced a significant decrease in both plasma renin activity (PRA) and plasma renin concentration (PRC). The time course of inhibition by cocaine in PRA and PRC revealed maximal effect at 15 min following a 15 mg/kg dose. In contrast, the long term administration of cocaine for 1, 7, or 30 days (15 mg/kg, twice daily, i.p.) did not produce changes in PRC. |
| doi_str_mv | 10.1016/0304-3940(91)90789-V |
| format | Article |
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Acute intraperitoneal administration of cocaine dose-dependently (1.5, 7.5, 15, and 30 mg/kg; at 15 min) produced a significant decrease in both plasma renin activity (PRA) and plasma renin concentration (PRC). The time course of inhibition by cocaine in PRA and PRC revealed maximal effect at 15 min following a 15 mg/kg dose. In contrast, the long term administration of cocaine for 1, 7, or 30 days (15 mg/kg, twice daily, i.p.) did not produce changes in PRC.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cocaine</subject><subject>Cocaine - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug abuse</subject><subject>Drug addictions</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuroendocrine system</subject><subject>Plasma renin activity</subject><subject>Plasma renin concentration</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Renin - blood</subject><subject>Renin - metabolism</subject><subject>Renin secretion</subject><subject>Renin-angiotensin system</subject><subject>Toxicology</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-LFDEQxYMo67j6DRRyEFHY1qrudCe5LCyL_2DBi-41pJNqjHSnxyQt-O3N7AzrTU9F1fu9onjF2HOEtwg4vIMORNNpAa81vtEglW5uH7AdKtk2Usv2IdvdI4_Zk5x_AECPvThjZ6gUDq3eMXfltkIXfNwKj2vhifZkC_kL7lZnQyRu_RJiyCXZEtbIPblENlOuaAyR50N_p9SmfKfqi9mFdct8sTPxanvKHk12zvTsVM_Ztw_vv15_am6-fPx8fXXTOIGyNG4ce61U2ysQgycSJKUH9GLyHdpJtO0IrQMYlUSvCYfB1bFWo0bR6dF35-zVce8-rT83ysUsITuaZxup3mNkCwNq7P8LYq-lHrquguIIurTmnGgy-xQWm34bBHN4gjkkbA4JG43m7gnmttpenPZv40L-r-mYetVfnnSbnZ2nZKML-R7rB8AeZcUujxjV0H4FSqYGS9GRD4lcMX4N_77jD_2No20</recordid><startdate>19910624</startdate><enddate>19910624</enddate><creator>Lakoski, Joan M.</creator><creator>Rittenhouse, Peter A.</creator><creator>Bonadonna, Anna M.</creator><creator>Van de Kar, Louis D.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19910624</creationdate><title>Acute, but not repeated, cocaine administration decreases renin secretion in the conscious male rat</title><author>Lakoski, Joan M. ; Rittenhouse, Peter A. ; Bonadonna, Anna M. ; Van de Kar, Louis D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-cbb5988258046dee4e77d01d4fd31af422b02c00b871d9e166c1af98b91439bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cocaine</topic><topic>Cocaine - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug abuse</topic><topic>Drug addictions</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuroendocrine system</topic><topic>Plasma renin activity</topic><topic>Plasma renin concentration</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Renin - blood</topic><topic>Renin - metabolism</topic><topic>Renin secretion</topic><topic>Renin-angiotensin system</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lakoski, Joan M.</creatorcontrib><creatorcontrib>Rittenhouse, Peter A.</creatorcontrib><creatorcontrib>Bonadonna, Anna M.</creatorcontrib><creatorcontrib>Van de Kar, Louis D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lakoski, Joan M.</au><au>Rittenhouse, Peter A.</au><au>Bonadonna, Anna M.</au><au>Van de Kar, Louis D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute, but not repeated, cocaine administration decreases renin secretion in the conscious male rat</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1991-06-24</date><risdate>1991</risdate><volume>127</volume><issue>2</issue><spage>181</spage><epage>184</epage><pages>181-184</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The effects of cocaine on renin secretion have been addressed and a previously unreported inhibitory effect has been identified on this neuroendocrine system in the conscious male rat. Acute intraperitoneal administration of cocaine dose-dependently (1.5, 7.5, 15, and 30 mg/kg; at 15 min) produced a significant decrease in both plasma renin activity (PRA) and plasma renin concentration (PRC). The time course of inhibition by cocaine in PRA and PRC revealed maximal effect at 15 min following a 15 mg/kg dose. In contrast, the long term administration of cocaine for 1, 7, or 30 days (15 mg/kg, twice daily, i.p.) did not produce changes in PRC.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>1881629</pmid><doi>10.1016/0304-3940(91)90789-V</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1991-06, Vol.127 (2), p.181-184 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Cocaine Cocaine - pharmacology Dose-Response Relationship, Drug Drug abuse Drug addictions Male Medical sciences Neuroendocrine system Plasma renin activity Plasma renin concentration Rats Rats, Inbred Strains Renin - blood Renin - metabolism Renin secretion Renin-angiotensin system Toxicology |
| title | Acute, but not repeated, cocaine administration decreases renin secretion in the conscious male rat |
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