Is there more to gaba than synaptic inhibition?

Key Points The amino acid GABA (γ-aminobutyric acid) was first identified in the mammalian brain over 50 years ago, and during the 1950s and 1960s, strong evidence accumulated that it acts as an inhibitory neurotransmitter in both vertebrate and invertebrate nervous systems. GABA is synthesized from...

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Veröffentlicht in:	Nature reviews. Neuroscience 2002-09, Vol.3 (9), p.715-727
Hauptverfasser:	Kriegstein, Arnold R, Owens, David F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Cell Differentiation - physiology Central Nervous System - cytology Central Nervous System - growth & development Central Nervous System - metabolism Enzymes gamma-Aminobutyric Acid - metabolism Gene Expression Regulation, Developmental - physiology Humans Metabolism Nerve Growth Factors - metabolism Nervous system Neural Inhibition - physiology Neurobiology Neurosciences Presynaptic Terminals - metabolism Presynaptic Terminals - ultrastructure Receptors, GABA - genetics Receptors, GABA - metabolism review-article Signal Transduction - physiology Synaptic Transmission - physiology Systems development
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