Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active cysteines in response to ionizing radiation

A recently identified class of signaling factors uses critical cysteine motif(s) that act as redox-sensitive 'sulfhydryl switches' to reversibly modulate specific signal transduction cascades regulating downstream proteins with similar redox-sensitive sites. For example, signaling factors...

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Veröffentlicht in:	Oncogene 2002-09, Vol.21 (41), p.6317-6327
Hauptverfasser:	KARIMPOUR, Shervin, JUNYANG LOU, SPITZ, Douglas R, HIROTA, Kiichi, KALVAKOLANU, Dhananjaya V, YODOI, Junji, GIUS, David, LIN, Lilie L, RENE, Luis M, LAGUNAS, Lucio, XINRONG MA, KARRA, Sreenivasu, BRADBURY, C. Matthew, MARKOVINA, Stephanie, GOSWAMI, Prabhat C
Format:	Artikel
Sprache:	eng
Schlagworte:	Activator protein 1 Biological and medical sciences Biology Cancer research Cell lines Cysteine Deoxyribonucleic acid DNA Fundamental and applied biological sciences. Psychology Gene expression HeLa Cells Humans Ionizing radiation Localization Medical research Molecular and cellular biology Molecular genetics Oncology Oxidative stress Oxidoreductase Proteins Radiation Redox factor-1 Reporter gene Selenocysteine Signal transduction Signal Transduction - genetics Thioredoxin Thioredoxin Reductase 1 Thioredoxin-Disulfide Reductase - genetics Thioredoxin-Disulfide Reductase - metabolism Thioredoxins - metabolism Transcription Factor AP-1 - genetics Transcription Factor AP-1 - metabolism Transcription factors Transcription. Transcription factor. Splicing. Rna processing
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