Multiple signaling pathways leading to the activation of interferon regulatory factor 3

Virus infection of susceptible cells activates multiple signaling pathways that orchestrate the activation of genes, such as cytokines, involved in the antiviral and innate immune response. Among the kinases induced are the mitogen-activated protein (MAP) kinases, Jun-amino terminal kinases (JNK) an...

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Veröffentlicht in:	Biochemical pharmacology 2002-09, Vol.64 (5-6), p.985-992
Hauptverfasser:	Servant, Marc J, Grandvaux, Nathalie, Hiscott, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology Humans Interferon Interferon Regulatory Factor-3 IRF-3 Lipopolysaccharides - pharmacology Molecular and cellular biology Molecular genetics NF-kappa B - metabolism Phosphorylation RNA, Double-Stranded - metabolism Signal Transduction - physiology Stress, Physiological - metabolism Toll-like receptors Transcription Transcription Factors - metabolism Transcription. Transcription factor. Splicing. Rna processing Virus Diseases - metabolism Viruses - metabolism
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