Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis

Copper plays an essential role in promoting angiogenesis. Tumors that become angiogenic acquire the ability to enter a phase of rapid growth and exhibit increased metastatic potential, the major cause of morbidity in cancer patients. We report that copper deficiency induced by tetrathiomolybdate (TM...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2002-09, Vol.62 (17), p.4854-4859
Hauptverfasser:	PAN, Quintin, KLEER, Celina G, BREWER, George J, MERAJVER, Sofia D, VAN GOLEN, Kenneth L, IRANI, Jennifer, BOTTEMA, Kristen M, BIAS, Carlos, DE CARVALHO, Magda, MESRI, Enrique A, ROBINS, Diane M, DICK, Robert D
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - pharmacology Animals Antineoplastic agents Biological and medical sciences Breast Neoplasms - blood supply Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Division - drug effects Chemotherapy Copper - deficiency Disease Models, Animal Female Genes, erbB-2 Humans Mammary Neoplasms, Experimental - blood supply Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - pathology Mammary Neoplasms, Experimental - prevention & control Medical sciences Mice Mice, Nude Mice, Transgenic Molybdenum - pharmacology Neovascularization, Pathologic - drug therapy NF-kappa B - genetics NF-kappa B - metabolism Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Transcription, Genetic Xenograft Model Antitumor Assays
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