SODIUM CHANNEL BLOCKING AND ANTIARRHYTHMIC ACTIONS OF THE NOVEL ARYLPIPERAZINE RSD992

Bolus doses (4–128 μmol kg −1) and infusions (2–32 μmol kg −1 min −1) of the novel arylpiperazine drug RSD992 produced bradycardia in rats and guinea pigs but had minimal effect on ECG variables. RSD992 (2–32 μmol kg −1 min −1) increased threshold current ( I T) for induction of extra-systoles and i...

Ausführliche Beschreibung