Localization of TIMP in cycling mouse hair
TIMP (tissue inhibitor of metalloproteinase) is a glycoprotein inhibitor of metalloproteinases that we hypothesize to be involved in the tissue remodeling that occurs during each hair growth cycle. We examined this hypothesis by studying the expression of TIMP at selected times during a single hair...
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| Veröffentlicht in: | Development (Cambridge) 1991-04, Vol.111 (4), p.877-879 |
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| container_title | Development (Cambridge) |
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| creator | KAWABE, T. T REA, T. J FLENNIKEN, A. M WILLIAMS, B. R. G GROPPI, V. E BUHL, A. E |
| description | TIMP (tissue inhibitor of metalloproteinase) is a glycoprotein inhibitor of metalloproteinases that we hypothesize to be involved in the tissue remodeling that occurs during each hair growth cycle. We examined this hypothesis by studying the expression of TIMP at selected times during a single hair cycle using TIMP-lacZ transgenic mice to localize TIMP gene activity in the hair follicle. TIMP gene induction was visualized by staining mouse back skin for beta-galactosidase (beta-gal) activity. Paraffin sections were analyzed for the localization of TIMP expression. TIMP gene activation appears in hair follicles only during the mid-anagen (the growing stage of the hair cycle) primarily in Henle's layer of the inner root sheath. Some expression of TIMP is also seen in a few connective tissue cells, in the sebaceous gland and in cells at the proximity of the dermal papilla cells in catagen (regressing) and telogen (resting) follicles. These results are consistent with a role for TIMP in cyclic remodeling of connective tissue in hair follicles. |
| doi_str_mv | 10.1242/dev.111.4.877 |
| format | Article |
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Some expression of TIMP is also seen in a few connective tissue cells, in the sebaceous gland and in cells at the proximity of the dermal papilla cells in catagen (regressing) and telogen (resting) follicles. These results are consistent with a role for TIMP in cyclic remodeling of connective tissue in hair follicles.</description><identifier>ISSN: 0950-1991</identifier><identifier>EISSN: 1477-9129</identifier><identifier>DOI: 10.1242/dev.111.4.877</identifier><identifier>PMID: 1908771</identifier><language>eng</language><publisher>Cambridge: The Company of Biologists Limited</publisher><subject>Animals ; beta-Galactosidase - analysis ; Biological and medical sciences ; Connective Tissue - physiology ; Fundamental and applied biological sciences. 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TIMP gene activation appears in hair follicles only during the mid-anagen (the growing stage of the hair cycle) primarily in Henle's layer of the inner root sheath. Some expression of TIMP is also seen in a few connective tissue cells, in the sebaceous gland and in cells at the proximity of the dermal papilla cells in catagen (regressing) and telogen (resting) follicles. These results are consistent with a role for TIMP in cyclic remodeling of connective tissue in hair follicles.</description><subject>Animals</subject><subject>beta-Galactosidase - analysis</subject><subject>Biological and medical sciences</subject><subject>Connective Tissue - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycoproteins - analysis</subject><subject>Glycoproteins - physiology</subject><subject>Hair - chemistry</subject><subject>Hair - growth & development</subject><subject>Metalloendopeptidases - antagonists & inhibitors</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Tissue Inhibitor of Metalloproteinases</subject><subject>Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue</subject><issn>0950-1991</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkD1PwzAQhi0EKqUwMiJlQAyIBJ9jx_GIKj4qFcFQZst17NYojUucgsqvx1UqYLkb7tF7dw9C54AzIJTcVuYzA4CMZiXnB2gIlPNUABGHaIgFwykIAcfoJIR3jHFecD5AAxA40jBE11OvVe2-Ved8k3ibzCbPr4lrEr3VtWsWycpvgkmWyrWn6MiqOpizfR-ht4f72fgpnb48TsZ301TnIu9SRg1UVldVRQrKcEWIjdcYWppKgWGUgwYKVlFDcy7wnGFVcGzLnFsVa5GP0FWfu279x8aETq5c0KauVWPiMZITzAQlZQTTHtStD6E1Vq5bt1LtVgKWOzcyupHRjaQyfhv5i33wZr4y1R_dy4jzy_1chSjFtqrRLvxirMC4LFjEbnps6RbLL9caOXe-9gsXurDbaGq__rf1B11ZeiE</recordid><startdate>19910401</startdate><enddate>19910401</enddate><creator>KAWABE, T. 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Psychology</topic><topic>Glycoproteins - analysis</topic><topic>Glycoproteins - physiology</topic><topic>Hair - chemistry</topic><topic>Hair - growth & development</topic><topic>Metalloendopeptidases - antagonists & inhibitors</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Tissue Inhibitor of Metalloproteinases</topic><topic>Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAWABE, T. T</creatorcontrib><creatorcontrib>REA, T. J</creatorcontrib><creatorcontrib>FLENNIKEN, A. M</creatorcontrib><creatorcontrib>WILLIAMS, B. R. G</creatorcontrib><creatorcontrib>GROPPI, V. E</creatorcontrib><creatorcontrib>BUHL, A. 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E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Localization of TIMP in cycling mouse hair</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>1991-04-01</date><risdate>1991</risdate><volume>111</volume><issue>4</issue><spage>877</spage><epage>879</epage><pages>877-879</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>TIMP (tissue inhibitor of metalloproteinase) is a glycoprotein inhibitor of metalloproteinases that we hypothesize to be involved in the tissue remodeling that occurs during each hair growth cycle. We examined this hypothesis by studying the expression of TIMP at selected times during a single hair cycle using TIMP-lacZ transgenic mice to localize TIMP gene activity in the hair follicle. TIMP gene induction was visualized by staining mouse back skin for beta-galactosidase (beta-gal) activity. Paraffin sections were analyzed for the localization of TIMP expression. TIMP gene activation appears in hair follicles only during the mid-anagen (the growing stage of the hair cycle) primarily in Henle's layer of the inner root sheath. Some expression of TIMP is also seen in a few connective tissue cells, in the sebaceous gland and in cells at the proximity of the dermal papilla cells in catagen (regressing) and telogen (resting) follicles. These results are consistent with a role for TIMP in cyclic remodeling of connective tissue in hair follicles.</abstract><cop>Cambridge</cop><pub>The Company of Biologists Limited</pub><pmid>1908771</pmid><doi>10.1242/dev.111.4.877</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0950-1991 |
| ispartof | Development (Cambridge), 1991-04, Vol.111 (4), p.877-879 |
| issn | 0950-1991 1477-9129 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Animals beta-Galactosidase - analysis Biological and medical sciences Connective Tissue - physiology Fundamental and applied biological sciences. Psychology Glycoproteins - analysis Glycoproteins - physiology Hair - chemistry Hair - growth & development Metalloendopeptidases - antagonists & inhibitors Mice Mice, Transgenic Tissue Inhibitor of Metalloproteinases Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue |
| title | Localization of TIMP in cycling mouse hair |
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