Clear-cell change in follicular adenoma mimicking hurthle-cell tumor on thyroid aspiration biopsy cytology
We present a case of follicular adenoma with clear‐cell change, which on fine‐needle aspiration biopsy mimicked a Hürthle‐cell tumor. Papanicolaou‐stained smears revealed a monomorphic pattern of loosely cohesive groups of cells with abundant cytoplasm and centrally placed round nuclei with single p...
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| Veröffentlicht in: | Diagnostic cytopathology 1991-01, Vol.7 (3), p.273-276 |
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| container_title | Diagnostic cytopathology |
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| creator | Orlando, Christine A. Salman, Karl Miller, Jeffrey L. Naryshkin, Sonya |
| description | We present a case of follicular adenoma with clear‐cell change, which on fine‐needle aspiration biopsy mimicked a Hürthle‐cell tumor. Papanicolaou‐stained smears revealed a monomorphic pattern of loosely cohesive groups of cells with abundant cytoplasm and centrally placed round nuclei with single prominent nucleoli. The cytoplasm was granular or finely vacuolated with occasional intracytoplasmic brown pigment. Subsequent surgical histology of the partial thyroidectomy specimen revealed a follicular adenoma composed of macro‐ and microfollicles. The microfollicular areas showed clear‐cell change; these cells appeared identical to those seen on cytology. No Hürthle‐cell change was present in the surgical specimen. Follicular cells with clear‐cell change of the granular type must be added to the list of differential diagnoses when cells with Hürthle‐like features are seen on aspiration biopsy of the thyroid. |
| doi_str_mv | 10.1002/dc.2840070312 |
| format | Article |
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Papanicolaou‐stained smears revealed a monomorphic pattern of loosely cohesive groups of cells with abundant cytoplasm and centrally placed round nuclei with single prominent nucleoli. The cytoplasm was granular or finely vacuolated with occasional intracytoplasmic brown pigment. Subsequent surgical histology of the partial thyroidectomy specimen revealed a follicular adenoma composed of macro‐ and microfollicles. The microfollicular areas showed clear‐cell change; these cells appeared identical to those seen on cytology. No Hürthle‐cell change was present in the surgical specimen. Follicular cells with clear‐cell change of the granular type must be added to the list of differential diagnoses when cells with Hürthle‐like features are seen on aspiration biopsy of the thyroid.</description><identifier>ISSN: 8755-1039</identifier><identifier>EISSN: 1097-0339</identifier><identifier>DOI: 10.1002/dc.2840070312</identifier><identifier>PMID: 1879263</identifier><identifier>CODEN: DICYE7</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenoma - diagnosis ; Adenoma - pathology ; Biological and medical sciences ; Biopsy, Needle ; Diagnosis ; Diagnosis, Differential ; Endocrinopathies ; Fine-needle aspiration ; Humans ; Male ; Medical sciences ; Middle Aged ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Thyroid neoplasm ; Thyroid Neoplasms - diagnosis ; Thyroid Neoplasms - pathology ; Thyroid. Thyroid axis (diseases)</subject><ispartof>Diagnostic cytopathology, 1991-01, Vol.7 (3), p.273-276</ispartof><rights>Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4032-dba34402ae84eaaf52d2edc75eb9a0966fe18b8b19f321fdae51514145a442473</citedby><cites>FETCH-LOGICAL-c4032-dba34402ae84eaaf52d2edc75eb9a0966fe18b8b19f321fdae51514145a442473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdc.2840070312$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdc.2840070312$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4548957$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1879263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Orlando, Christine A.</creatorcontrib><creatorcontrib>Salman, Karl</creatorcontrib><creatorcontrib>Miller, Jeffrey L.</creatorcontrib><creatorcontrib>Naryshkin, Sonya</creatorcontrib><title>Clear-cell change in follicular adenoma mimicking hurthle-cell tumor on thyroid aspiration biopsy cytology</title><title>Diagnostic cytopathology</title><addtitle>Diagn. Cytopathol</addtitle><description>We present a case of follicular adenoma with clear‐cell change, which on fine‐needle aspiration biopsy mimicked a Hürthle‐cell tumor. Papanicolaou‐stained smears revealed a monomorphic pattern of loosely cohesive groups of cells with abundant cytoplasm and centrally placed round nuclei with single prominent nucleoli. The cytoplasm was granular or finely vacuolated with occasional intracytoplasmic brown pigment. Subsequent surgical histology of the partial thyroidectomy specimen revealed a follicular adenoma composed of macro‐ and microfollicles. The microfollicular areas showed clear‐cell change; these cells appeared identical to those seen on cytology. No Hürthle‐cell change was present in the surgical specimen. Follicular cells with clear‐cell change of the granular type must be added to the list of differential diagnoses when cells with Hürthle‐like features are seen on aspiration biopsy of the thyroid.</description><subject>Adenoma - diagnosis</subject><subject>Adenoma - pathology</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>Diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Endocrinopathies</subject><subject>Fine-needle aspiration</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Thyroid neoplasm</subject><subject>Thyroid Neoplasms - diagnosis</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid. Thyroid axis (diseases)</subject><issn>8755-1039</issn><issn>1097-0339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1v1DAQxS1EVZbCkSOSD4hbWn_G8REWSBFt4QDiaE0cZ9etE2_tRJD_nl1l1YpLTyPN_N6bp4fQG0rOKSHsorXnrBKEKMIpe4ZWlGhVEM71c7SqlJQFJVy_QC9zviWEaEbLU3RKK6VZyVfodh0cpMK6ELDdwrBx2A-4iyF4OwVIGFo3xB5w73tv7_ywwdspjdvgFs049THhOOBxO6foWwx55xOMfr9qfNzlGdt5jCFu5lfopIOQ3evjPEO_vnz-ub4srr7XX9cfrgorCGdF2wAXgjBwlXAAnWQtc61V0jUaiC7LztGqqRqqO85o14KTVFJBhQQhmFD8DL1ffHcp3k8uj6b3-RAWBhenbBQjUnMi9mCxgDbFnJPrzC75HtJsKDGHbk1rzWO3e_7t0Xhqetc-0kuZ-_u74x2yhdAlGKzPD5iQotLykE8t2B8f3Pz0T_Np_V-AY2CfR_f3QQnpzpSKK2l-39Smvq5vLj_WP8w3_g-me6HJ</recordid><startdate>19910101</startdate><enddate>19910101</enddate><creator>Orlando, Christine A.</creator><creator>Salman, Karl</creator><creator>Miller, Jeffrey L.</creator><creator>Naryshkin, Sonya</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910101</creationdate><title>Clear-cell change in follicular adenoma mimicking hurthle-cell tumor on thyroid aspiration biopsy cytology</title><author>Orlando, Christine A. ; Salman, Karl ; Miller, Jeffrey L. ; Naryshkin, Sonya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4032-dba34402ae84eaaf52d2edc75eb9a0966fe18b8b19f321fdae51514145a442473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adenoma - diagnosis</topic><topic>Adenoma - pathology</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle</topic><topic>Diagnosis</topic><topic>Diagnosis, Differential</topic><topic>Endocrinopathies</topic><topic>Fine-needle aspiration</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Thyroid neoplasm</topic><topic>Thyroid Neoplasms - diagnosis</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid. Thyroid axis (diseases)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orlando, Christine A.</creatorcontrib><creatorcontrib>Salman, Karl</creatorcontrib><creatorcontrib>Miller, Jeffrey L.</creatorcontrib><creatorcontrib>Naryshkin, Sonya</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diagnostic cytopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orlando, Christine A.</au><au>Salman, Karl</au><au>Miller, Jeffrey L.</au><au>Naryshkin, Sonya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clear-cell change in follicular adenoma mimicking hurthle-cell tumor on thyroid aspiration biopsy cytology</atitle><jtitle>Diagnostic cytopathology</jtitle><addtitle>Diagn. Cytopathol</addtitle><date>1991-01-01</date><risdate>1991</risdate><volume>7</volume><issue>3</issue><spage>273</spage><epage>276</epage><pages>273-276</pages><issn>8755-1039</issn><eissn>1097-0339</eissn><coden>DICYE7</coden><abstract>We present a case of follicular adenoma with clear‐cell change, which on fine‐needle aspiration biopsy mimicked a Hürthle‐cell tumor. Papanicolaou‐stained smears revealed a monomorphic pattern of loosely cohesive groups of cells with abundant cytoplasm and centrally placed round nuclei with single prominent nucleoli. The cytoplasm was granular or finely vacuolated with occasional intracytoplasmic brown pigment. Subsequent surgical histology of the partial thyroidectomy specimen revealed a follicular adenoma composed of macro‐ and microfollicles. The microfollicular areas showed clear‐cell change; these cells appeared identical to those seen on cytology. No Hürthle‐cell change was present in the surgical specimen. Follicular cells with clear‐cell change of the granular type must be added to the list of differential diagnoses when cells with Hürthle‐like features are seen on aspiration biopsy of the thyroid.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>1879263</pmid><doi>10.1002/dc.2840070312</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8755-1039 |
| ispartof | Diagnostic cytopathology, 1991-01, Vol.7 (3), p.273-276 |
| issn | 8755-1039 1097-0339 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adenoma - diagnosis Adenoma - pathology Biological and medical sciences Biopsy, Needle Diagnosis Diagnosis, Differential Endocrinopathies Fine-needle aspiration Humans Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Thyroid neoplasm Thyroid Neoplasms - diagnosis Thyroid Neoplasms - pathology Thyroid. Thyroid axis (diseases) |
| title | Clear-cell change in follicular adenoma mimicking hurthle-cell tumor on thyroid aspiration biopsy cytology |
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