Absence of Polymorphism of Sparteine Oxidation in the South African Venda

Absence of Polymorphism of Sparteine Oxidation in the South African Venda

1 This study has found no occurrence of poor metabolism of sparteine within a South African Venda populaton of 97 subjects. 2 On the basis of MR (metabolic ratio) the mean and distribution of the results are very similar to those found in Ghanaians.5,14 3 The distribution is also similar to that for...

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Veröffentlicht in:Human & experimental toxicology 1991-05, Vol.10 (3), p.175-178
Hauptverfasser: Sommers, De K., Moncrieff, J., Avenant, J.C.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
African Continental Ancestry Group - genetics
Female
Humans
Male
Oxidation-Reduction
Polymorphism, Genetic - genetics
South Africa
Sparteine - metabolism
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Zusammenfassung:1 This study has found no occurrence of poor metabolism of sparteine within a South African Venda populaton of 97 subjects. 2 On the basis of MR (metabolic ratio) the mean and distribution of the results are very similar to those found in Ghanaians.5,14 3 The distribution is also similar to that for fast metabolizers in Caucasians.14 4 It is concluded that different P450 cytochromes are responsible for immediate oxidation of debrisoquine and sparteine, but that both may be activated by the same P450 reductase.
ISSN:0960-3271
1477-0903
DOI:10.1177/096032719101000304