Apolipoprotein E and other cerebrospinal fluid proteins differentiate ante mortem variant Creutzfeldt-Jakob disease from ante mortem sporadic Creutzfeldt-Jakob disease
The ability to perform an ante mortem differential diagnosis of Creutzfeld‐Jakob disease (CJD) is aided by several clinical and molecular tests. There is a need for molecular tests which can reliably distinguish ante mortem variant CJD (vCJD) from ante mortem sporadic CJD (spCJD). A proteomics appro...
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| Veröffentlicht in: | Electrophoresis 2002-07, Vol.23 (14), p.2242-2246 |
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| creator | Choe, Leila H. Green, Alison Knight, Richard S. G. Thompson, Edward J. Lee, Kelvin H. |
| description | The ability to perform an ante mortem differential diagnosis of Creutzfeld‐Jakob disease (CJD) is aided by several clinical and molecular tests. There is a need for molecular tests which can reliably distinguish ante mortem variant CJD (vCJD) from ante mortem sporadic CJD (spCJD). A proteomics approach employing two‐dimensional protein electrophoresis is applied to the study of ante mortem CSF samples obtained in collaboration with the CJD Surveillance Unit and the National Hospital for Neurology and Neurosurgery. The sample set includes two cases of vCJD, three cases of spCJD and three neurologic controls. Preliminary data using a panel of seven molecular markers is able to distinguish vCJD from spCJD using a heuristic clustering algorithm. One of the molecular markers has been identified as apolipoprotein E which appears to be upregulated in the cerebrospiral fluid (CSF) of patients with vCJD as compared to spCJD. Analysis of ante mortem CSF may help to differentiate patients with vCJD from those patients with spCJD. |
| doi_str_mv | 10.1002/1522-2683(200207)23:14<2242::AID-ELPS2242>3.0.CO;2-F |
| format | Article |
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One of the molecular markers has been identified as apolipoprotein E which appears to be upregulated in the cerebrospiral fluid (CSF) of patients with vCJD as compared to spCJD. Analysis of ante mortem CSF may help to differentiate patients with vCJD from those patients with spCJD.</description><identifier>ISSN: 0173-0835</identifier><identifier>EISSN: 1522-2683</identifier><identifier>DOI: 10.1002/1522-2683(200207)23:14<2242::AID-ELPS2242>3.0.CO;2-F</identifier><identifier>PMID: 12210228</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag GmbH</publisher><subject>Adult ; Aged ; Algorithms ; Apolipoproteins E - cerebrospinal fluid ; Biomarkers - cerebrospinal fluid ; Case-Control Studies ; Cerebrospinal fluid ; Cerebrospinal Fluid Proteins - analysis ; Creutzfeldt-Jakob disease ; Creutzfeldt-Jakob Syndrome - cerebrospinal fluid ; Creutzfeldt-Jakob Syndrome - classification ; Creutzfeldt-Jakob Syndrome - diagnosis ; Diagnosis, Differential ; Electrophoresis, Gel, Two-Dimensional ; Female ; Humans ; Male ; Middle Aged ; Prion ; Proteomics</subject><ispartof>Electrophoresis, 2002-07, Vol.23 (14), p.2242-2246</ispartof><rights>2002 WILEY‐VCH Verlag GmbH, Weinheim, Fed. 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G.</creatorcontrib><creatorcontrib>Thompson, Edward J.</creatorcontrib><creatorcontrib>Lee, Kelvin H.</creatorcontrib><title>Apolipoprotein E and other cerebrospinal fluid proteins differentiate ante mortem variant Creutzfeldt-Jakob disease from ante mortem sporadic Creutzfeldt-Jakob disease</title><title>Electrophoresis</title><addtitle>ELECTROPHORESIS</addtitle><description>The ability to perform an ante mortem differential diagnosis of Creutzfeld‐Jakob disease (CJD) is aided by several clinical and molecular tests. There is a need for molecular tests which can reliably distinguish ante mortem variant CJD (vCJD) from ante mortem sporadic CJD (spCJD). A proteomics approach employing two‐dimensional protein electrophoresis is applied to the study of ante mortem CSF samples obtained in collaboration with the CJD Surveillance Unit and the National Hospital for Neurology and Neurosurgery. The sample set includes two cases of vCJD, three cases of spCJD and three neurologic controls. Preliminary data using a panel of seven molecular markers is able to distinguish vCJD from spCJD using a heuristic clustering algorithm. One of the molecular markers has been identified as apolipoprotein E which appears to be upregulated in the cerebrospiral fluid (CSF) of patients with vCJD as compared to spCJD. Analysis of ante mortem CSF may help to differentiate patients with vCJD from those patients with spCJD.</description><subject>Adult</subject><subject>Aged</subject><subject>Algorithms</subject><subject>Apolipoproteins E - cerebrospinal fluid</subject><subject>Biomarkers - cerebrospinal fluid</subject><subject>Case-Control Studies</subject><subject>Cerebrospinal fluid</subject><subject>Cerebrospinal Fluid Proteins - analysis</subject><subject>Creutzfeldt-Jakob disease</subject><subject>Creutzfeldt-Jakob Syndrome - cerebrospinal fluid</subject><subject>Creutzfeldt-Jakob Syndrome - classification</subject><subject>Creutzfeldt-Jakob Syndrome - diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Electrophoresis, Gel, Two-Dimensional</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prion</subject><subject>Proteomics</subject><issn>0173-0835</issn><issn>1522-2683</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkcGO0zAQhiMEYsvCK6CcEBxS7LFdJ2WFVIV22VW1RWIR4jRyHEeYTZpgJ8DyQrwmjlKKOOyBi8dj__8_sr8oOqNkTgmBl1QAJLBI2XMILZEvgC0pPwPgsFyuLt4k6-2792P3ms3JPN-9gmRzL5odbfejGaGSJSRl4iR65P0XQgjPOH8YnVAASgDSWfRr1bW17drOtb2x-3gdq30Zt_1n42JtnClc6zu7V3Vc1YMt44POx6WtqnC_763qTTCFpWldb5r4m3I29HHuzND_rExd9smlummL4PFGeRNXrm3-sfiudaq0-m7P4-hBpWpvnhzqafRhs77O3ybb3flFvtommhMOiSChVIWUrCozXUqaChWKXADPiNSEMqVSEfaFpMKkmmqxYFoLMIISKYCdRs-m3PDQr4PxPTbWa1PXam_awaMEIlLGsiC8noQ6_JB3psLO2Ua5W6QER4A4ksCRBE4AERhSjiMyxAAQ_wBEhgTzHQJuQuzTw_yhaEz5N_RALAg-TYLvtja3_zX0jpnHs5CdTNnW9-bHMVu5G1xIJgV-vDrHS36VbSkTSNlvqCvHYw</recordid><startdate>20020701</startdate><enddate>20020701</enddate><creator>Choe, Leila H.</creator><creator>Green, Alison</creator><creator>Knight, Richard S. G.</creator><creator>Thompson, Edward J.</creator><creator>Lee, Kelvin H.</creator><general>WILEY-VCH Verlag GmbH</general><general>WILEY‐VCH Verlag GmbH</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020701</creationdate><title>Apolipoprotein E and other cerebrospinal fluid proteins differentiate ante mortem variant Creutzfeldt-Jakob disease from ante mortem sporadic Creutzfeldt-Jakob disease</title><author>Choe, Leila H. ; Green, Alison ; Knight, Richard S. G. ; Thompson, Edward J. ; Lee, Kelvin H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4042-50404fb773fd9cd7185acd77624907c013aa85490b715e8c1c563cc52e5107523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Algorithms</topic><topic>Apolipoproteins E - cerebrospinal fluid</topic><topic>Biomarkers - cerebrospinal fluid</topic><topic>Case-Control Studies</topic><topic>Cerebrospinal fluid</topic><topic>Cerebrospinal Fluid Proteins - analysis</topic><topic>Creutzfeldt-Jakob disease</topic><topic>Creutzfeldt-Jakob Syndrome - cerebrospinal fluid</topic><topic>Creutzfeldt-Jakob Syndrome - classification</topic><topic>Creutzfeldt-Jakob Syndrome - diagnosis</topic><topic>Diagnosis, Differential</topic><topic>Electrophoresis, Gel, Two-Dimensional</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prion</topic><topic>Proteomics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choe, Leila H.</creatorcontrib><creatorcontrib>Green, Alison</creatorcontrib><creatorcontrib>Knight, Richard S. 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G.</au><au>Thompson, Edward J.</au><au>Lee, Kelvin H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apolipoprotein E and other cerebrospinal fluid proteins differentiate ante mortem variant Creutzfeldt-Jakob disease from ante mortem sporadic Creutzfeldt-Jakob disease</atitle><jtitle>Electrophoresis</jtitle><addtitle>ELECTROPHORESIS</addtitle><date>2002-07-01</date><risdate>2002</risdate><volume>23</volume><issue>14</issue><spage>2242</spage><epage>2246</epage><pages>2242-2246</pages><issn>0173-0835</issn><eissn>1522-2683</eissn><abstract>The ability to perform an ante mortem differential diagnosis of Creutzfeld‐Jakob disease (CJD) is aided by several clinical and molecular tests. There is a need for molecular tests which can reliably distinguish ante mortem variant CJD (vCJD) from ante mortem sporadic CJD (spCJD). A proteomics approach employing two‐dimensional protein electrophoresis is applied to the study of ante mortem CSF samples obtained in collaboration with the CJD Surveillance Unit and the National Hospital for Neurology and Neurosurgery. The sample set includes two cases of vCJD, three cases of spCJD and three neurologic controls. Preliminary data using a panel of seven molecular markers is able to distinguish vCJD from spCJD using a heuristic clustering algorithm. One of the molecular markers has been identified as apolipoprotein E which appears to be upregulated in the cerebrospiral fluid (CSF) of patients with vCJD as compared to spCJD. Analysis of ante mortem CSF may help to differentiate patients with vCJD from those patients with spCJD.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag GmbH</pub><pmid>12210228</pmid><doi>10.1002/1522-2683(200207)23:14<2242::AID-ELPS2242>3.0.CO;2-F</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Algorithms Apolipoproteins E - cerebrospinal fluid Biomarkers - cerebrospinal fluid Case-Control Studies Cerebrospinal fluid Cerebrospinal Fluid Proteins - analysis Creutzfeldt-Jakob disease Creutzfeldt-Jakob Syndrome - cerebrospinal fluid Creutzfeldt-Jakob Syndrome - classification Creutzfeldt-Jakob Syndrome - diagnosis Diagnosis, Differential Electrophoresis, Gel, Two-Dimensional Female Humans Male Middle Aged Prion Proteomics |
| title | Apolipoprotein E and other cerebrospinal fluid proteins differentiate ante mortem variant Creutzfeldt-Jakob disease from ante mortem sporadic Creutzfeldt-Jakob disease |
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