The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2

ING1b is a candidate tumor suppressor that can stimulate the transcriptional activity of p53 and inhibit cell proliferation. The molecular basis of how ING1b activates p53 function remains unclear. Here we show that ING1b could stimulate the activity of p53 by increasing the level and stability of t...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2002-09, Vol.62 (17), p.4890-4893
Hauptverfasser:	KA MAN LEUNG, LAI SEE PO, FAN CHEUNG TSANG, WAI YI SIU, LAU, Anita, HO, Horace T. B, POON, Randy Y. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding, Competitive Biological and medical sciences Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Cycle Proteins Cell Division - physiology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes DNA-Binding Proteins Fundamental and applied biological sciences. Psychology Genes, Tumor Suppressor Humans Inhibitor of Growth Protein 1 Intracellular Signaling Peptides and Proteins Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Molecular and cellular biology Nuclear Proteins Protein Isoforms Proteins - metabolism Proteins - physiology Transcription, Genetic Tumor Cells, Cultured Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Protein p53 - physiology Tumor Suppressor Proteins
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