Comparison of in vitro and in vivo release characteristics of acetaminophen from gradient matrix systems
An effort was made to correlate the in vivo and in vitro release data of acetaminophen from two formulations of a recently developed controlled‐release system, the Gradient Matrix System (GMS‐1 and GMS‐2). The in vivo release curves, obtained by deconvolution of the plasma concentration time plots,...
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| Veröffentlicht in: | Biopharmaceutics & drug disposition 1991-07, Vol.12 (5), p.367-373 |
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| container_end_page | 373 |
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| container_issue | 5 |
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| container_title | Biopharmaceutics & drug disposition |
| container_volume | 12 |
| creator | Van Bommel, Elvira M. G. Raghoebar, Maikel Tukker, Josef J. |
| description | An effort was made to correlate the in vivo and in vitro release data of acetaminophen from two formulations of a recently developed controlled‐release system, the Gradient Matrix System (GMS‐1 and GMS‐2). The in vivo release curves, obtained by deconvolution of the plasma concentration time plots, showed a small inter‐subject variability. GMS‐1 with fastest in vitro release also showed fastest in vivo release. A good relationship was only found after time‐scaling of the release data. |
| doi_str_mv | 10.1002/bdd.2510120506 |
| format | Article |
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G.</creatorcontrib><creatorcontrib>Raghoebar, Maikel</creatorcontrib><creatorcontrib>Tukker, Josef J.</creatorcontrib><title>Comparison of in vitro and in vivo release characteristics of acetaminophen from gradient matrix systems</title><title>Biopharmaceutics & drug disposition</title><addtitle>Biopharm. Drug Dispos</addtitle><description>An effort was made to correlate the in vivo and in vitro release data of acetaminophen from two formulations of a recently developed controlled‐release system, the Gradient Matrix System (GMS‐1 and GMS‐2). The in vivo release curves, obtained by deconvolution of the plasma concentration time plots, showed a small inter‐subject variability. GMS‐1 with fastest in vitro release also showed fastest in vivo release. A good relationship was only found after time‐scaling of the release data.</description><subject>Acetaminophen</subject><subject>Acetaminophen - pharmacokinetics</subject><subject>Administration, Oral</subject><subject>Algorithms</subject><subject>Analgesics</subject><subject>Biological and medical sciences</subject><subject>Delayed-Action Preparations</subject><subject>Gradient matrix system</subject><subject>Humans</subject><subject>In vivo/In vitro correlation</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Oral controlled delivery</subject><subject>Pharmacology. 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G.</creatorcontrib><creatorcontrib>Raghoebar, Maikel</creatorcontrib><creatorcontrib>Tukker, Josef J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biopharmaceutics & drug disposition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Bommel, Elvira M. G.</au><au>Raghoebar, Maikel</au><au>Tukker, Josef J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of in vitro and in vivo release characteristics of acetaminophen from gradient matrix systems</atitle><jtitle>Biopharmaceutics & drug disposition</jtitle><addtitle>Biopharm. Drug Dispos</addtitle><date>1991-07</date><risdate>1991</risdate><volume>12</volume><issue>5</issue><spage>367</spage><epage>373</epage><pages>367-373</pages><issn>0142-2782</issn><eissn>1099-081X</eissn><coden>BDDID8</coden><abstract>An effort was made to correlate the in vivo and in vitro release data of acetaminophen from two formulations of a recently developed controlled‐release system, the Gradient Matrix System (GMS‐1 and GMS‐2). The in vivo release curves, obtained by deconvolution of the plasma concentration time plots, showed a small inter‐subject variability. GMS‐1 with fastest in vitro release also showed fastest in vivo release. A good relationship was only found after time‐scaling of the release data.</abstract><cop>New York</cop><pub>John Wiley & Sons, Ltd</pub><pmid>1878533</pmid><doi>10.1002/bdd.2510120506</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0142-2782 |
| ispartof | Biopharmaceutics & drug disposition, 1991-07, Vol.12 (5), p.367-373 |
| issn | 0142-2782 1099-081X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72057309 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Acetaminophen Acetaminophen - pharmacokinetics Administration, Oral Algorithms Analgesics Biological and medical sciences Delayed-Action Preparations Gradient matrix system Humans In vivo/In vitro correlation Medical sciences Neuropharmacology Oral controlled delivery Pharmacology. Drug treatments |
| title | Comparison of in vitro and in vivo release characteristics of acetaminophen from gradient matrix systems |
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