Effect of Locally Delivered Minocycline Microspheres on Markers of Bone Resorption
Background: Gingival crevicular fluid (GCF) biomarkers associated with bone resorption may be useful to determine periodontal disease status and response to therapy. The pyridinoline cross‐linked carboxy‐terminal telopeptide of type I collagen (ICTP), a bone‐specific degradation product, and interle...
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| Veröffentlicht in: | Journal of periodontology (1970) 2002-08, Vol.73 (8), p.835-842 |
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| creator | Oringer, R.J. Al‐Shammari, K.F. Aldredge, W.A. Iacono, V.J. Eber, R.M. Wang, H.L. Berwald, B. Nejat, R. Giannobile, W.V. |
| description | Background: Gingival crevicular fluid (GCF) biomarkers associated with bone resorption may be useful to determine periodontal disease status and response to therapy. The pyridinoline cross‐linked carboxy‐terminal telopeptide of type I collagen (ICTP), a bone‐specific degradation product, and interleukin 1‐beta (IL‐1), a potent bone‐resorptive cytokine, have both been associated with periodontal disease activity. Minocycline is a tetracycline derivative possessing antimicrobial effects on periodontal pathogens and inhibitory properties on matrix metalloproteinases (MMPs) associated with tissue destruction. The aim of this study was to evaluate the effect of periodontal treatment in the form of scaling and root planing (SRP) and locally administered minocycline microspheres on the GCF levels of ICTP and IL‐1.
Methods: Forty‐eight chronic periodontitis patients were randomly assigned to 2 groups (SRP plus subgingival application of vehicle control [SRP + V], or SRP plus subgingival application of minocycline microspheres [SRP + M]) and monitored at 8 sites per subject at baseline and 1, 3, and 6 months. Four shallow (PD ≤3 mm) and 4 deep (PD ≥5 mm) sites were evaluated for both marker levels and for probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP). Eight periodontally healthy control subjects with no probing depths >3 mm and no loss of attachment were also monitored at the same time intervals. GCF levels of ICTP and IL‐1 were determined using radioimmunoassay and enzyme‐linked immunosorbent assay techniques, respectively.
Results: Significant differences (P |
| doi_str_mv | 10.1902/jop.2002.73.8.835 |
| format | Article |
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Methods: Forty‐eight chronic periodontitis patients were randomly assigned to 2 groups (SRP plus subgingival application of vehicle control [SRP + V], or SRP plus subgingival application of minocycline microspheres [SRP + M]) and monitored at 8 sites per subject at baseline and 1, 3, and 6 months. Four shallow (PD ≤3 mm) and 4 deep (PD ≥5 mm) sites were evaluated for both marker levels and for probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP). Eight periodontally healthy control subjects with no probing depths >3 mm and no loss of attachment were also monitored at the same time intervals. GCF levels of ICTP and IL‐1 were determined using radioimmunoassay and enzyme‐linked immunosorbent assay techniques, respectively.
Results: Significant differences (P <0.001) in GCF levels of ICTP and IL‐1 were found between deep and shallow sites at all time points in both treatment groups. In addition, healthy subjects demonstrated significantly reduced levels of both markers compared to both shallow and deep sites in periodontitis patients (P <0.001). Only the SRP + M treated patients exhibited significant reductions (P <0.05) in both ICTP and IL‐1 levels 1 month after treatment. Furthermore, the SRP + M group demonstrated significantly lower IL‐1 levels (P <0.02) at 1 month compared to the SRP + V group.
Conclusions: Results of this study indicate that GCF levels of ICTP and IL‐1 correlate with clinical measures of periodontal disease and may aid in assessing disease status and response to periodontal therapy. Furthermore, local administration of minocycline microspheres led to a potent short‐term reduction in GCF IL‐1 levels. Additional studies are needed to address whether repeated administration of scaling and root planing along with minocycline microspheres will achieve long‐term reductions in GCF ICTP and IL‐1 levels. J Periodontol 2002;73:835‐842.</description><identifier>ISSN: 0022-3492</identifier><identifier>EISSN: 1943-3670</identifier><identifier>DOI: 10.1902/jop.2002.73.8.835</identifier><identifier>PMID: 12211491</identifier><language>eng</language><publisher>737 N. Michigan Avenue, Suite 800, Chicago, IL 60611‐2690, USA: American Academy of Periodontology</publisher><subject>Administration, Topical ; Adult ; Aged ; Analysis of Variance ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - therapeutic use ; Biomarkers - analysis ; Bone resorption ; Bone Resorption - drug therapy ; Bone Resorption - therapy ; Chronic Disease ; clinical trials ; collagen ; Collagen - analysis ; Collagen - drug effects ; Collagen Type I ; Dental Scaling ; Dentistry ; drug delivery systems ; Female ; Follow-Up Studies ; Gingival Crevicular Fluid - chemistry ; Gingival Hemorrhage - drug therapy ; Gingival Hemorrhage - therapy ; Humans ; Interleukin-1 - analysis ; interleukin‐1 ; Male ; Matched-Pair Analysis ; Microspheres ; Middle Aged ; Minocycline - administration & dosage ; Minocycline - therapeutic use ; Peptides - analysis ; Peptides - drug effects ; Periodontal Attachment Loss - drug therapy ; Periodontal Attachment Loss - therapy ; periodontal diseases/therapy ; Periodontal Pocket - drug therapy ; Periodontal Pocket - therapy ; Periodontitis - drug therapy ; Periodontitis - therapy ; pyridinoline cross‐links ; Root Planing ; Single-Blind Method ; Statistics as Topic</subject><ispartof>Journal of periodontology (1970), 2002-08, Vol.73 (8), p.835-842</ispartof><rights>2002 American Academy of Periodontology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3305-5ef8027a6e610edd4306e01cb56ea66380abc00fd5b36e9189e3ebe786c4f0c73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1902%2Fjop.2002.73.8.835$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1902%2Fjop.2002.73.8.835$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12211491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oringer, R.J.</creatorcontrib><creatorcontrib>Al‐Shammari, K.F.</creatorcontrib><creatorcontrib>Aldredge, W.A.</creatorcontrib><creatorcontrib>Iacono, V.J.</creatorcontrib><creatorcontrib>Eber, R.M.</creatorcontrib><creatorcontrib>Wang, H.L.</creatorcontrib><creatorcontrib>Berwald, B.</creatorcontrib><creatorcontrib>Nejat, R.</creatorcontrib><creatorcontrib>Giannobile, W.V.</creatorcontrib><title>Effect of Locally Delivered Minocycline Microspheres on Markers of Bone Resorption</title><title>Journal of periodontology (1970)</title><addtitle>J Periodontol</addtitle><description>Background: Gingival crevicular fluid (GCF) biomarkers associated with bone resorption may be useful to determine periodontal disease status and response to therapy. The pyridinoline cross‐linked carboxy‐terminal telopeptide of type I collagen (ICTP), a bone‐specific degradation product, and interleukin 1‐beta (IL‐1), a potent bone‐resorptive cytokine, have both been associated with periodontal disease activity. Minocycline is a tetracycline derivative possessing antimicrobial effects on periodontal pathogens and inhibitory properties on matrix metalloproteinases (MMPs) associated with tissue destruction. The aim of this study was to evaluate the effect of periodontal treatment in the form of scaling and root planing (SRP) and locally administered minocycline microspheres on the GCF levels of ICTP and IL‐1.
Methods: Forty‐eight chronic periodontitis patients were randomly assigned to 2 groups (SRP plus subgingival application of vehicle control [SRP + V], or SRP plus subgingival application of minocycline microspheres [SRP + M]) and monitored at 8 sites per subject at baseline and 1, 3, and 6 months. Four shallow (PD ≤3 mm) and 4 deep (PD ≥5 mm) sites were evaluated for both marker levels and for probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP). Eight periodontally healthy control subjects with no probing depths >3 mm and no loss of attachment were also monitored at the same time intervals. GCF levels of ICTP and IL‐1 were determined using radioimmunoassay and enzyme‐linked immunosorbent assay techniques, respectively.
Results: Significant differences (P <0.001) in GCF levels of ICTP and IL‐1 were found between deep and shallow sites at all time points in both treatment groups. In addition, healthy subjects demonstrated significantly reduced levels of both markers compared to both shallow and deep sites in periodontitis patients (P <0.001). Only the SRP + M treated patients exhibited significant reductions (P <0.05) in both ICTP and IL‐1 levels 1 month after treatment. Furthermore, the SRP + M group demonstrated significantly lower IL‐1 levels (P <0.02) at 1 month compared to the SRP + V group.
Conclusions: Results of this study indicate that GCF levels of ICTP and IL‐1 correlate with clinical measures of periodontal disease and may aid in assessing disease status and response to periodontal therapy. Furthermore, local administration of minocycline microspheres led to a potent short‐term reduction in GCF IL‐1 levels. Additional studies are needed to address whether repeated administration of scaling and root planing along with minocycline microspheres will achieve long‐term reductions in GCF ICTP and IL‐1 levels. J Periodontol 2002;73:835‐842.</description><subject>Administration, Topical</subject><subject>Adult</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Biomarkers - analysis</subject><subject>Bone resorption</subject><subject>Bone Resorption - drug therapy</subject><subject>Bone Resorption - therapy</subject><subject>Chronic Disease</subject><subject>clinical trials</subject><subject>collagen</subject><subject>Collagen - analysis</subject><subject>Collagen - drug effects</subject><subject>Collagen Type I</subject><subject>Dental Scaling</subject><subject>Dentistry</subject><subject>drug delivery systems</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gingival Crevicular Fluid - chemistry</subject><subject>Gingival Hemorrhage - drug therapy</subject><subject>Gingival Hemorrhage - therapy</subject><subject>Humans</subject><subject>Interleukin-1 - analysis</subject><subject>interleukin‐1</subject><subject>Male</subject><subject>Matched-Pair Analysis</subject><subject>Microspheres</subject><subject>Middle Aged</subject><subject>Minocycline - administration & dosage</subject><subject>Minocycline - therapeutic use</subject><subject>Peptides - analysis</subject><subject>Peptides - drug effects</subject><subject>Periodontal Attachment Loss - drug therapy</subject><subject>Periodontal Attachment Loss - therapy</subject><subject>periodontal diseases/therapy</subject><subject>Periodontal Pocket - drug therapy</subject><subject>Periodontal Pocket - therapy</subject><subject>Periodontitis - drug therapy</subject><subject>Periodontitis - therapy</subject><subject>pyridinoline cross‐links</subject><subject>Root Planing</subject><subject>Single-Blind Method</subject><subject>Statistics as Topic</subject><issn>0022-3492</issn><issn>1943-3670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlOwzAQhi0EoqXwAFxQTtwSxnbiOEeWsqkVqIKz5TgTkZLGwW5BfXsctRJHTuPRv2j8EXJOIaEFsKul7RMGwJKcJzKRPDsgY1qkPOYih0MyDhKLeVqwETnxfhlWmnI4JiPKGKVpQcdkMa1rNOvI1tHMGt222-gO2-YbHVbRvOms2Zq26TC8jbO-_wiCj2wXzbX7ROeH4I0N-gK9df26sd0pOap16_FsPyfk_X76dvsYz14enm6vZ7HhHLI4w1oCy7VAQQGrKlwmEKgpM4FaCC5BlwagrrKSCyyoLJBjibkUJq3B5HxCLne9vbNfG_RrtWq8wbbVHdqNVzmDTBQSgpHujMMPvMNa9a5ZabdVFNQAUgWQagCpcq6kCiBD5mJfvilXWP0l9uSCId8ZfpoWt_83qufX6QKG6l_74IBZ</recordid><startdate>200208</startdate><enddate>200208</enddate><creator>Oringer, R.J.</creator><creator>Al‐Shammari, K.F.</creator><creator>Aldredge, W.A.</creator><creator>Iacono, V.J.</creator><creator>Eber, R.M.</creator><creator>Wang, H.L.</creator><creator>Berwald, B.</creator><creator>Nejat, R.</creator><creator>Giannobile, W.V.</creator><general>American Academy of Periodontology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200208</creationdate><title>Effect of Locally Delivered Minocycline Microspheres on Markers of Bone Resorption</title><author>Oringer, R.J. ; Al‐Shammari, K.F. ; Aldredge, W.A. ; Iacono, V.J. ; Eber, R.M. ; Wang, H.L. ; Berwald, B. ; Nejat, R. ; Giannobile, W.V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3305-5ef8027a6e610edd4306e01cb56ea66380abc00fd5b36e9189e3ebe786c4f0c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Administration, Topical</topic><topic>Adult</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Biomarkers - analysis</topic><topic>Bone resorption</topic><topic>Bone Resorption - drug therapy</topic><topic>Bone Resorption - therapy</topic><topic>Chronic Disease</topic><topic>clinical trials</topic><topic>collagen</topic><topic>Collagen - analysis</topic><topic>Collagen - drug effects</topic><topic>Collagen Type I</topic><topic>Dental Scaling</topic><topic>Dentistry</topic><topic>drug delivery systems</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gingival Crevicular Fluid - chemistry</topic><topic>Gingival Hemorrhage - drug therapy</topic><topic>Gingival Hemorrhage - therapy</topic><topic>Humans</topic><topic>Interleukin-1 - analysis</topic><topic>interleukin‐1</topic><topic>Male</topic><topic>Matched-Pair Analysis</topic><topic>Microspheres</topic><topic>Middle Aged</topic><topic>Minocycline - administration & dosage</topic><topic>Minocycline - therapeutic use</topic><topic>Peptides - analysis</topic><topic>Peptides - drug effects</topic><topic>Periodontal Attachment Loss - drug therapy</topic><topic>Periodontal Attachment Loss - therapy</topic><topic>periodontal diseases/therapy</topic><topic>Periodontal Pocket - drug therapy</topic><topic>Periodontal Pocket - therapy</topic><topic>Periodontitis - drug therapy</topic><topic>Periodontitis - therapy</topic><topic>pyridinoline cross‐links</topic><topic>Root Planing</topic><topic>Single-Blind Method</topic><topic>Statistics as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oringer, R.J.</creatorcontrib><creatorcontrib>Al‐Shammari, K.F.</creatorcontrib><creatorcontrib>Aldredge, W.A.</creatorcontrib><creatorcontrib>Iacono, V.J.</creatorcontrib><creatorcontrib>Eber, R.M.</creatorcontrib><creatorcontrib>Wang, H.L.</creatorcontrib><creatorcontrib>Berwald, B.</creatorcontrib><creatorcontrib>Nejat, R.</creatorcontrib><creatorcontrib>Giannobile, W.V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of periodontology (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oringer, R.J.</au><au>Al‐Shammari, K.F.</au><au>Aldredge, W.A.</au><au>Iacono, V.J.</au><au>Eber, R.M.</au><au>Wang, H.L.</au><au>Berwald, B.</au><au>Nejat, R.</au><au>Giannobile, W.V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Locally Delivered Minocycline Microspheres on Markers of Bone Resorption</atitle><jtitle>Journal of periodontology (1970)</jtitle><addtitle>J Periodontol</addtitle><date>2002-08</date><risdate>2002</risdate><volume>73</volume><issue>8</issue><spage>835</spage><epage>842</epage><pages>835-842</pages><issn>0022-3492</issn><eissn>1943-3670</eissn><abstract>Background: Gingival crevicular fluid (GCF) biomarkers associated with bone resorption may be useful to determine periodontal disease status and response to therapy. The pyridinoline cross‐linked carboxy‐terminal telopeptide of type I collagen (ICTP), a bone‐specific degradation product, and interleukin 1‐beta (IL‐1), a potent bone‐resorptive cytokine, have both been associated with periodontal disease activity. Minocycline is a tetracycline derivative possessing antimicrobial effects on periodontal pathogens and inhibitory properties on matrix metalloproteinases (MMPs) associated with tissue destruction. The aim of this study was to evaluate the effect of periodontal treatment in the form of scaling and root planing (SRP) and locally administered minocycline microspheres on the GCF levels of ICTP and IL‐1.
Methods: Forty‐eight chronic periodontitis patients were randomly assigned to 2 groups (SRP plus subgingival application of vehicle control [SRP + V], or SRP plus subgingival application of minocycline microspheres [SRP + M]) and monitored at 8 sites per subject at baseline and 1, 3, and 6 months. Four shallow (PD ≤3 mm) and 4 deep (PD ≥5 mm) sites were evaluated for both marker levels and for probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP). Eight periodontally healthy control subjects with no probing depths >3 mm and no loss of attachment were also monitored at the same time intervals. GCF levels of ICTP and IL‐1 were determined using radioimmunoassay and enzyme‐linked immunosorbent assay techniques, respectively.
Results: Significant differences (P <0.001) in GCF levels of ICTP and IL‐1 were found between deep and shallow sites at all time points in both treatment groups. In addition, healthy subjects demonstrated significantly reduced levels of both markers compared to both shallow and deep sites in periodontitis patients (P <0.001). Only the SRP + M treated patients exhibited significant reductions (P <0.05) in both ICTP and IL‐1 levels 1 month after treatment. Furthermore, the SRP + M group demonstrated significantly lower IL‐1 levels (P <0.02) at 1 month compared to the SRP + V group.
Conclusions: Results of this study indicate that GCF levels of ICTP and IL‐1 correlate with clinical measures of periodontal disease and may aid in assessing disease status and response to periodontal therapy. Furthermore, local administration of minocycline microspheres led to a potent short‐term reduction in GCF IL‐1 levels. Additional studies are needed to address whether repeated administration of scaling and root planing along with minocycline microspheres will achieve long‐term reductions in GCF ICTP and IL‐1 levels. J Periodontol 2002;73:835‐842.</abstract><cop>737 N. Michigan Avenue, Suite 800, Chicago, IL 60611‐2690, USA</cop><pub>American Academy of Periodontology</pub><pmid>12211491</pmid><doi>10.1902/jop.2002.73.8.835</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Topical Adult Aged Analysis of Variance Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Biomarkers - analysis Bone resorption Bone Resorption - drug therapy Bone Resorption - therapy Chronic Disease clinical trials collagen Collagen - analysis Collagen - drug effects Collagen Type I Dental Scaling Dentistry drug delivery systems Female Follow-Up Studies Gingival Crevicular Fluid - chemistry Gingival Hemorrhage - drug therapy Gingival Hemorrhage - therapy Humans Interleukin-1 - analysis interleukin‐1 Male Matched-Pair Analysis Microspheres Middle Aged Minocycline - administration & dosage Minocycline - therapeutic use Peptides - analysis Peptides - drug effects Periodontal Attachment Loss - drug therapy Periodontal Attachment Loss - therapy periodontal diseases/therapy Periodontal Pocket - drug therapy Periodontal Pocket - therapy Periodontitis - drug therapy Periodontitis - therapy pyridinoline cross‐links Root Planing Single-Blind Method Statistics as Topic |
| title | Effect of Locally Delivered Minocycline Microspheres on Markers of Bone Resorption |
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