Autocrine secretion of an EGF-like substance by a cell line (HSC-1) derived from a human skin squamous cell carcinoma
The presence of EGF-autocrine secretion was investigated in a cell line derived from a human squamous cell carcinoma (HSC-1). The cell line was found to secrete the epidermal growth factor (EGF)-like substance. Meanwhile, normal human and uninvolved and involved psoriatic epidermal cells did not sho...
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| Veröffentlicht in: | Journal of dermatological science 1991-05, Vol.2 (3), p.161-165 |
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| container_title | Journal of dermatological science |
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| creator | Kondo, Shigeo Hozumi, Yutaka Aso, Kazuo |
| description | The presence of EGF-autocrine secretion was investigated in a cell line derived from a human squamous cell carcinoma (HSC-1). The cell line was found to secrete the epidermal growth factor (EGF)-like substance. Meanwhile, normal human and uninvolved and involved psoriatic epidermal cells did not show any evidence of EGF secretion in culture. Not was any evidence of EGF secretion observed in vitro in several malignant cell lines other than HSC-1 derived from human squamous cell carcinomas, adenocarcinoma and melanoma. The addition of EGF did not stimulate, but rather inhibited, the growth of HSC-1 cells in GIT medium as well as Dulbecco's modified essential medium with low concentrations of fetal calf serum (0.5–1%) in vitro. Overexpression of EGF receptors is known to occur in HSC-1. The results suggest that HSC-1 cells exhibit autocrine secretion of the EGF-like substance but not autostimulation in anchorage-dependent cell culture. |
| doi_str_mv | 10.1016/0923-1811(91)90062-3 |
| format | Article |
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The results suggest that HSC-1 cells exhibit autocrine secretion of the EGF-like substance but not autostimulation in anchorage-dependent cell culture.</description><identifier>ISSN: 0923-1811</identifier><identifier>EISSN: 1873-569X</identifier><identifier>DOI: 10.1016/0923-1811(91)90062-3</identifier><identifier>PMID: 1878344</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>Autocrine ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - secretion ; Cell Division - drug effects ; Culture Media ; Epidermal growth factor ; Epidermal Growth Factor - secretion ; HSC-1 cell line ; Humans ; Reference Values ; Skin - cytology ; Skin - secretion ; Skin Neoplasms - pathology ; Skin Neoplasms - secretion ; Squamous cell carcinoma ; Time Factors ; Tumor Cells, Cultured</subject><ispartof>Journal of dermatological science, 1991-05, Vol.2 (3), p.161-165</ispartof><rights>1991</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-8faaec094d41d303d9608fd6951535fd83d33e50a537fadbc038c61c9bcbd7023</citedby><cites>FETCH-LOGICAL-c338t-8faaec094d41d303d9608fd6951535fd83d33e50a537fadbc038c61c9bcbd7023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0923-1811(91)90062-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1878344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kondo, Shigeo</creatorcontrib><creatorcontrib>Hozumi, Yutaka</creatorcontrib><creatorcontrib>Aso, Kazuo</creatorcontrib><title>Autocrine secretion of an EGF-like substance by a cell line (HSC-1) derived from a human skin squamous cell carcinoma</title><title>Journal of dermatological science</title><addtitle>J Dermatol Sci</addtitle><description>The presence of EGF-autocrine secretion was investigated in a cell line derived from a human squamous cell carcinoma (HSC-1). The cell line was found to secrete the epidermal growth factor (EGF)-like substance. Meanwhile, normal human and uninvolved and involved psoriatic epidermal cells did not show any evidence of EGF secretion in culture. Not was any evidence of EGF secretion observed in vitro in several malignant cell lines other than HSC-1 derived from human squamous cell carcinomas, adenocarcinoma and melanoma. The addition of EGF did not stimulate, but rather inhibited, the growth of HSC-1 cells in GIT medium as well as Dulbecco's modified essential medium with low concentrations of fetal calf serum (0.5–1%) in vitro. Overexpression of EGF receptors is known to occur in HSC-1. The results suggest that HSC-1 cells exhibit autocrine secretion of the EGF-like substance but not autostimulation in anchorage-dependent cell culture.</description><subject>Autocrine</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - secretion</subject><subject>Cell Division - drug effects</subject><subject>Culture Media</subject><subject>Epidermal growth factor</subject><subject>Epidermal Growth Factor - secretion</subject><subject>HSC-1 cell line</subject><subject>Humans</subject><subject>Reference Values</subject><subject>Skin - cytology</subject><subject>Skin - secretion</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - secretion</subject><subject>Squamous cell carcinoma</subject><subject>Time Factors</subject><subject>Tumor Cells, Cultured</subject><issn>0923-1811</issn><issn>1873-569X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMoOj7-gUJWMrOoJk1f2QjDMA9BcKGCu5AmtxinbWaSVph_b0pFd0K4WZxz7uND6JqSO0podk94zCJaUDrldMYJyeKIHaEJLXIWpRl_P0aTX8sZOvf-kxCSxgk_RafBVLAkmaB-3ndWOdMC9qAcdMa22FZYtni5XkW12QahL30nWwW4PGCJFdQ1rofEdPOyiOgMa3DmCzSunG2C4aNvQtxvTSj7Xja292NISadMaxt5iU4qWXu4-vkv0Ntq-brYRE_P68fF_ClSjBVdVFRSgiI80QnVjDDNM1JUOuMpTVla6YJpxiAlMmV5JXWpCCtURhUvValzErMLdDv23Tm778F3ojF-WEW2ELYSeUzSLOM8GJPRqJz13kElds400h0EJWKgLQaUYkApeHgDbcFC7Oanf182oP9CI96gP4w6hCO_DDjhlYFAUhsHqhPamv8HfAP13o4c</recordid><startdate>199105</startdate><enddate>199105</enddate><creator>Kondo, Shigeo</creator><creator>Hozumi, Yutaka</creator><creator>Aso, Kazuo</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199105</creationdate><title>Autocrine secretion of an EGF-like substance by a cell line (HSC-1) derived from a human skin squamous cell carcinoma</title><author>Kondo, Shigeo ; Hozumi, Yutaka ; Aso, Kazuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-8faaec094d41d303d9608fd6951535fd83d33e50a537fadbc038c61c9bcbd7023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Autocrine</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - secretion</topic><topic>Cell Division - drug effects</topic><topic>Culture Media</topic><topic>Epidermal growth factor</topic><topic>Epidermal Growth Factor - secretion</topic><topic>HSC-1 cell line</topic><topic>Humans</topic><topic>Reference Values</topic><topic>Skin - cytology</topic><topic>Skin - secretion</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - secretion</topic><topic>Squamous cell carcinoma</topic><topic>Time Factors</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kondo, Shigeo</creatorcontrib><creatorcontrib>Hozumi, Yutaka</creatorcontrib><creatorcontrib>Aso, Kazuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatological science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kondo, Shigeo</au><au>Hozumi, Yutaka</au><au>Aso, Kazuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autocrine secretion of an EGF-like substance by a cell line (HSC-1) derived from a human skin squamous cell carcinoma</atitle><jtitle>Journal of dermatological science</jtitle><addtitle>J Dermatol Sci</addtitle><date>1991-05</date><risdate>1991</risdate><volume>2</volume><issue>3</issue><spage>161</spage><epage>165</epage><pages>161-165</pages><issn>0923-1811</issn><eissn>1873-569X</eissn><abstract>The presence of EGF-autocrine secretion was investigated in a cell line derived from a human squamous cell carcinoma (HSC-1). 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| ispartof | Journal of dermatological science, 1991-05, Vol.2 (3), p.161-165 |
| issn | 0923-1811 1873-569X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Autocrine Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - secretion Cell Division - drug effects Culture Media Epidermal growth factor Epidermal Growth Factor - secretion HSC-1 cell line Humans Reference Values Skin - cytology Skin - secretion Skin Neoplasms - pathology Skin Neoplasms - secretion Squamous cell carcinoma Time Factors Tumor Cells, Cultured |
| title | Autocrine secretion of an EGF-like substance by a cell line (HSC-1) derived from a human skin squamous cell carcinoma |
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