Synergistic roles of IgM and complement in antigen trapping and follicular localization

We have investigated the roles of IgM and complement (C) in the enhancement of primary immune responses and the localization of protein antigen (Ag) in the spleen. Pentameric but not monomericIgM enhances antibody (Ab) responses in both wild‐type and secretory μ‐deficient (μs–/–) mice, indicating th...

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Veröffentlicht in:	European journal of immunology 2002-08, Vol.32 (8), p.2328-2337
Hauptverfasser:	Youd, Michele E., Ferguson, Andrew R., Corley, Ronald B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen trapping Antigen-Antibody Complex - analysis Antigens - metabolism Complement Complement C3 - physiology Dendritic Cells, Follicular - immunology Follicular dendritic cell IgM Immunoglobulin M - physiology Mice Receptors, Complement - physiology Spleen - immunology
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