Microwave exposure induces Hsp70 and confers protection against hypoxia in chick embryos
To determine if microwave exposure could elicit a biological effect in the absence of thermal stress, studies were designed in which chick embryos were exposed to athermal microwave radiation (915 MHz) to look for induction of Hsp70, a protein produced during times of cellular stress that aids in th...
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| Veröffentlicht in: | Journal of cellular biochemistry 2002, Vol.86 (3), p.490-496 |
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| container_end_page | 496 |
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| container_issue | 3 |
| container_start_page | 490 |
| container_title | Journal of cellular biochemistry |
| container_volume | 86 |
| creator | Shallom, Joshua M. Di Carlo, Andrea L. Ko, Daejin Penafiel, L. Miguel Nakai, Akira Litovitz, Theodore A. |
| description | To determine if microwave exposure could elicit a biological effect in the absence of thermal stress, studies were designed in which chick embryos were exposed to athermal microwave radiation (915 MHz) to look for induction of Hsp70, a protein produced during times of cellular stress that aids in the protection of cellular components. Levels of Hsp70 were found to increase within 2 h, with maximum expression (∼30% higher than controls) typically occurring by 3 h from the start of exposure. Other embryos were exposed to microwave radiation prior to being subjected to hypoxic stress, and were found to have significantly higher survival (P |
| doi_str_mv | 10.1002/jcb.10243 |
| format | Article |
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Miguel ; Nakai, Akira ; Litovitz, Theodore A.</creator><creatorcontrib>Shallom, Joshua M. ; Di Carlo, Andrea L. ; Ko, Daejin ; Penafiel, L. Miguel ; Nakai, Akira ; Litovitz, Theodore A.</creatorcontrib><description>To determine if microwave exposure could elicit a biological effect in the absence of thermal stress, studies were designed in which chick embryos were exposed to athermal microwave radiation (915 MHz) to look for induction of Hsp70, a protein produced during times of cellular stress that aids in the protection of cellular components. Levels of Hsp70 were found to increase within 2 h, with maximum expression (∼30% higher than controls) typically occurring by 3 h from the start of exposure. Other embryos were exposed to microwave radiation prior to being subjected to hypoxic stress, and were found to have significantly higher survival (P < 0.05) following re‐oxygenation than non‐exposed controls. The results of these studies indicate that not only can athermal microwave exposures activate the stress protein response pathway; they can also enhance survivability following exposure to a subsequent, potentially lethal stress. From a public health standpoint, it is important that more studies be performed to determine if repeated exposures, a condition likely to be found in cell phone use, are still beneficial. J. Cell. 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Miguel</creatorcontrib><creatorcontrib>Nakai, Akira</creatorcontrib><creatorcontrib>Litovitz, Theodore A.</creatorcontrib><title>Microwave exposure induces Hsp70 and confers protection against hypoxia in chick embryos</title><title>Journal of cellular biochemistry</title><addtitle>J. Cell. Biochem</addtitle><description>To determine if microwave exposure could elicit a biological effect in the absence of thermal stress, studies were designed in which chick embryos were exposed to athermal microwave radiation (915 MHz) to look for induction of Hsp70, a protein produced during times of cellular stress that aids in the protection of cellular components. Levels of Hsp70 were found to increase within 2 h, with maximum expression (∼30% higher than controls) typically occurring by 3 h from the start of exposure. Other embryos were exposed to microwave radiation prior to being subjected to hypoxic stress, and were found to have significantly higher survival (P < 0.05) following re‐oxygenation than non‐exposed controls. The results of these studies indicate that not only can athermal microwave exposures activate the stress protein response pathway; they can also enhance survivability following exposure to a subsequent, potentially lethal stress. From a public health standpoint, it is important that more studies be performed to determine if repeated exposures, a condition likely to be found in cell phone use, are still beneficial. J. Cell. Biochem. 86: 490–496, 2002. © 2002 Wiley‐Liss, Inc.</description><subject>Adaptation, Physiological - radiation effects</subject><subject>Animals</subject><subject>athermal microwave radiation</subject><subject>Chick Embryo - metabolism</subject><subject>Chick Embryo - radiation effects</subject><subject>Cytoprotection - radiation effects</subject><subject>electromagnetic fields</subject><subject>HSP70 Heat-Shock Proteins - metabolism</subject><subject>HSP70 Heat-Shock Proteins - radiation effects</subject><subject>Hypoxia - metabolism</subject><subject>Microwaves</subject><subject>stress proteins</subject><subject>Stress, Physiological - metabolism</subject><subject>Survival Analysis</subject><subject>Temperature</subject><issn>0730-2312</issn><issn>1097-4644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1O6zAQhS10EZSfBS9w5dWVWATGdlwnS6goBfEjJBDsLMeZgKFNgp1A-_YYWi4rVjOL7xzNfITsMThgAPzw2RZx4alYIwMGuUrSYZr-IQNQAhIuGN8kWyE8A0CeC75BNhnnDJSUA_Jw6axv3s0bUpy3Teg9UleXvcVAJ6FVQE1dUtvUFfpAW990aDvX1NQ8GleHjj4t2mbuTAxR--TsC8VZ4RdN2CHrlZkG3F3NbXI3PrkdTZKL69Oz0dFFYlMuRZLJokTF1DAbcl7FtZASS0BhVFawjLFIVZVCJiUwLmyqbJYpkAxNbssiE9vk37I33vbaY-j0zAWL06mpsemDVhyk5MAjuL8E478heKx0693M-IVmoD816qhRf2mM7N9VaV_MsPwhV94icLgE3t0UF7836fPR8Xdlsky40OH8f8L4Fz1UQkl9f3Wqx8c3Uua3uZ6ID3KPisQ</recordid><startdate>2002</startdate><enddate>2002</enddate><creator>Shallom, Joshua M.</creator><creator>Di Carlo, Andrea L.</creator><creator>Ko, Daejin</creator><creator>Penafiel, L. 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Miguel ; Nakai, Akira ; Litovitz, Theodore A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4253-85bde71768622fde7b55ed0e3a78b1811425ff7e1550123c47c887051ea9cdb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adaptation, Physiological - radiation effects</topic><topic>Animals</topic><topic>athermal microwave radiation</topic><topic>Chick Embryo - metabolism</topic><topic>Chick Embryo - radiation effects</topic><topic>Cytoprotection - radiation effects</topic><topic>electromagnetic fields</topic><topic>HSP70 Heat-Shock Proteins - metabolism</topic><topic>HSP70 Heat-Shock Proteins - radiation effects</topic><topic>Hypoxia - metabolism</topic><topic>Microwaves</topic><topic>stress proteins</topic><topic>Stress, Physiological - metabolism</topic><topic>Survival Analysis</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shallom, Joshua M.</creatorcontrib><creatorcontrib>Di Carlo, Andrea L.</creatorcontrib><creatorcontrib>Ko, Daejin</creatorcontrib><creatorcontrib>Penafiel, L. 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| ispartof | Journal of cellular biochemistry, 2002, Vol.86 (3), p.490-496 |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adaptation, Physiological - radiation effects Animals athermal microwave radiation Chick Embryo - metabolism Chick Embryo - radiation effects Cytoprotection - radiation effects electromagnetic fields HSP70 Heat-Shock Proteins - metabolism HSP70 Heat-Shock Proteins - radiation effects Hypoxia - metabolism Microwaves stress proteins Stress, Physiological - metabolism Survival Analysis Temperature |
| title | Microwave exposure induces Hsp70 and confers protection against hypoxia in chick embryos |
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