Solution technique to incorporate polyethylene oxide and other water-soluble polymers into surfaces of polymeric biomaterials
A simple solution technique was used to incorporate polyethylene oxide (PEO, of 5000,10 000,18 500, and 100 000 g/mol) and other water-soluble polymers such as polyvinylpyrrolidone and polyethyl oxazoline into the surfaces of commonly used biomedical polymers such as polyethylene terephthalate, a Po...
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| Veröffentlicht in: | Biomaterials 1991-03, Vol.12 (2), p.144-153 |
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| container_title | Biomaterials |
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| creator | Desai, Neil P. Hubbell, Jeffrey A. |
| description | A simple solution technique was used to incorporate polyethylene oxide (PEO, of 5000,10 000,18 500, and 100 000 g/mol) and other water-soluble polymers such as polyvinylpyrrolidone and polyethyl oxazoline into the surfaces of commonly used biomedical polymers such as polyethylene terephthalate, a Polyurethane (Pellethane® 2363-80AE), and polymethylmethacrylate. The presence of the water-soluble polymers on these surfaces was verified by using contact angle analysis and ESCA. Protein adsorption studies, fibroblast adhesion assays, and whole blood perfusions over these polymers showed that the surface modified with PEO 18 500 was the most effective in reducing all the tested biological interactions. It was concluded that PEO 18 500 had a chain length that was optimal, using this technique for surface incorporation, to reduce protein adsorption and hence prevent protein-mediated biological interactions. |
| doi_str_mv | 10.1016/0142-9612(91)90193-E |
| format | Article |
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The presence of the water-soluble polymers on these surfaces was verified by using contact angle analysis and ESCA. Protein adsorption studies, fibroblast adhesion assays, and whole blood perfusions over these polymers showed that the surface modified with PEO 18 500 was the most effective in reducing all the tested biological interactions. It was concluded that PEO 18 500 had a chain length that was optimal, using this technique for surface incorporation, to reduce protein adsorption and hence prevent protein-mediated biological interactions.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/0142-9612(91)90193-E</identifier><identifier>PMID: 1831675</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adsorption ; Albumins - metabolism ; Biocompatible Materials ; Biological and medical sciences ; Blood-polymer interactions ; Fibroblasts - metabolism ; In Vitro Techniques ; Medical sciences ; Microscopy, Electron, Scanning ; Molecular Weight ; Platelet Adhesiveness ; Polyethylene Glycols - chemistry ; polyethylene oxide ; Polyethylene Terephthalates ; Polymers - chemistry ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Solubility ; Surface Properties ; surface treatment ; Technology. Biomaterials. Equipments. Material. 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The presence of the water-soluble polymers on these surfaces was verified by using contact angle analysis and ESCA. Protein adsorption studies, fibroblast adhesion assays, and whole blood perfusions over these polymers showed that the surface modified with PEO 18 500 was the most effective in reducing all the tested biological interactions. It was concluded that PEO 18 500 had a chain length that was optimal, using this technique for surface incorporation, to reduce protein adsorption and hence prevent protein-mediated biological interactions.</description><subject>Adsorption</subject><subject>Albumins - metabolism</subject><subject>Biocompatible Materials</subject><subject>Biological and medical sciences</subject><subject>Blood-polymer interactions</subject><subject>Fibroblasts - metabolism</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Molecular Weight</subject><subject>Platelet Adhesiveness</subject><subject>Polyethylene Glycols - chemistry</subject><subject>polyethylene oxide</subject><subject>Polyethylene Terephthalates</subject><subject>Polymers - chemistry</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Solubility</subject><subject>Surface Properties</subject><subject>surface treatment</subject><subject>Technology. Biomaterials. Equipments. Material. Instrumentation</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMGL1DAYxYMo6zj6HyjkouihmjRt2lwEWWZ1YcGDeg7ply9MpG3GJHWdg_-7GTu6tz19hPd7j7xHyHPO3nLG5TvGm7pSktevFX-jGFei2j0gG953fdUq1j4km__IY_Ikpe-svFlTX5AL3gsuu3ZDfn8J45J9mGlG2M_-x4I0B-pnCPEQoslID2E8Yt4fR5yRhl_eIjWzpSHvMdLbQsQqlZBhXNEJYyr-EpKW6AxgosH9UzzQwYfpZPJmTE_JI1cOPjvfLfl2tft6-am6-fzx-vLDTQWi73Jlne0bgBYGJZhtmDFcCFN3zlnm1CCZHXqhFANeu1LLOe46C7KTppcK0IotebXmHmIoDVPWk0-A42hmDEvSXc1aoYQsYLOCEENKEZ0-RD-ZeNSc6dPq-jSpPk2qFdd_V9e7Yntxzl-GCe2daZ256C_PuklgRhfNDD7dYUpK2ZeoLXm_cljG-Okx6gQe51LBR4SsbfD3f-QPHGOiow</recordid><startdate>19910301</startdate><enddate>19910301</enddate><creator>Desai, Neil P.</creator><creator>Hubbell, Jeffrey A.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910301</creationdate><title>Solution technique to incorporate polyethylene oxide and other water-soluble polymers into surfaces of polymeric biomaterials</title><author>Desai, Neil P. ; Hubbell, Jeffrey A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-dfd84cc5cb930d40aa133a27ffd0f9b60db83990c12f167ff1f7dc676a869ced3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adsorption</topic><topic>Albumins - metabolism</topic><topic>Biocompatible Materials</topic><topic>Biological and medical sciences</topic><topic>Blood-polymer interactions</topic><topic>Fibroblasts - metabolism</topic><topic>In Vitro Techniques</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>Molecular Weight</topic><topic>Platelet Adhesiveness</topic><topic>Polyethylene Glycols - chemistry</topic><topic>polyethylene oxide</topic><topic>Polyethylene Terephthalates</topic><topic>Polymers - chemistry</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Solubility</topic><topic>Surface Properties</topic><topic>surface treatment</topic><topic>Technology. Biomaterials. Equipments. Material. Instrumentation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Desai, Neil P.</creatorcontrib><creatorcontrib>Hubbell, Jeffrey A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Desai, Neil P.</au><au>Hubbell, Jeffrey A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Solution technique to incorporate polyethylene oxide and other water-soluble polymers into surfaces of polymeric biomaterials</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>1991-03-01</date><risdate>1991</risdate><volume>12</volume><issue>2</issue><spage>144</spage><epage>153</epage><pages>144-153</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>A simple solution technique was used to incorporate polyethylene oxide (PEO, of 5000,10 000,18 500, and 100 000 g/mol) and other water-soluble polymers such as polyvinylpyrrolidone and polyethyl oxazoline into the surfaces of commonly used biomedical polymers such as polyethylene terephthalate, a Polyurethane (Pellethane® 2363-80AE), and polymethylmethacrylate. The presence of the water-soluble polymers on these surfaces was verified by using contact angle analysis and ESCA. Protein adsorption studies, fibroblast adhesion assays, and whole blood perfusions over these polymers showed that the surface modified with PEO 18 500 was the most effective in reducing all the tested biological interactions. It was concluded that PEO 18 500 had a chain length that was optimal, using this technique for surface incorporation, to reduce protein adsorption and hence prevent protein-mediated biological interactions.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>1831675</pmid><doi>10.1016/0142-9612(91)90193-E</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0142-9612 |
| ispartof | Biomaterials, 1991-03, Vol.12 (2), p.144-153 |
| issn | 0142-9612 1878-5905 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72053936 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adsorption Albumins - metabolism Biocompatible Materials Biological and medical sciences Blood-polymer interactions Fibroblasts - metabolism In Vitro Techniques Medical sciences Microscopy, Electron, Scanning Molecular Weight Platelet Adhesiveness Polyethylene Glycols - chemistry polyethylene oxide Polyethylene Terephthalates Polymers - chemistry Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Solubility Surface Properties surface treatment Technology. Biomaterials. Equipments. Material. Instrumentation |
| title | Solution technique to incorporate polyethylene oxide and other water-soluble polymers into surfaces of polymeric biomaterials |
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