Disposition and pharmacodynamics of dichloroacetate (DCA) and oxalate following oral DCA doses

Healthy volunteers received intravenous and/or oral doses of sodium dichloroacetate (DCA) in various single and multiple dose regimens. A crossover bioavailability study proved abortive because second and subsequent doses showed significantly longer terminal elimination half‐lives (means 3·64 h and...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 1991-07, Vol.12 (5), p.375-390
Hauptverfasser:	Curry, Stephen H., Lorenz, Anthea, Pei-ichu, Limacher, Marion, Stacpoole, Peter W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent Adult Biological and medical sciences Biological Availability Biotransformation Blood Pressure Monitors Dichloroacetate Dichloroacetic Acid - administration & dosage Dichloroacetic Acid - pharmacokinetics Digit Symbol Echocardiography Echocardiography - drug effects Female Half-Life Heart Rate - drug effects Humans Male Medical sciences Middle Aged Oxalate Oxalates - pharmacokinetics Pharmacology. Drug treatments Sex Differences in Pharmacokinetics Sex Factors Skin, nail, hair, dermoskeleton Substitution Unavailability
Online-Zugang:	Volltext
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