Determination of para-aminobenzoic acid, a degradation product of procaine hydrochloride, by zero-crossing first-derivative spectrometry

Determination of para-aminobenzoic acid, a degradation product of procaine hydrochloride, by zero-crossing first-derivative spectrometry

A first derivative spectrometric method has been developed for the determination of the para-aminobenzoic acid (PABA), a related substance and degradation product of the local anesthetic procaine hydrochloride (PH). The wavelength selected for the determination of para-aminobenzoic acid in the prese...

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Veröffentlicht in:Analytical and bioanalytical chemistry 2002-09, Vol.374 (1), p.51-53
Hauptverfasser: Badea, Irinel, Moja, Dana, Vladescu, Luminita
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Moja, Dana
Vladescu, Luminita
description A first derivative spectrometric method has been developed for the determination of the para-aminobenzoic acid (PABA), a related substance and degradation product of the local anesthetic procaine hydrochloride (PH). The wavelength selected for the determination of para-aminobenzoic acid in the presence of procaine was 290 nm. At this wavelength the calibration graphs relating the amplitude of the signals to the concentration of para-aminobenzoic acid were linear up to 10 mg L(-1). The detection limit of para-aminobenzoic acid was 0.70 mg L(-1). The method is simple and rapid and does not require preliminary treatment of the sample. The method was validated.
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title Determination of para-aminobenzoic acid, a degradation product of procaine hydrochloride, by zero-crossing first-derivative spectrometry
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