Comparative diagnostic value and therapeutic relevance of magnetic resonance imaging and bone marrow scintigraphy in patients with metastatic solid tumors of the axial skeleton
Purpose: To evaluate the comparative impact of magnetic resonance imaging (MRI) and bone marrow scintigraphy (BMS) in bone marrow metastases of solid tumors. Methods: In 20 patients with solid tumors MRI of the axial skeleton and whole-body BMS were retrospectively reviewed. Detectability of metasta...
Gespeichert in:
| Veröffentlicht in: | European journal of radiology 2002-09, Vol.43 (3), p.256-261 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 261 |
|---|---|
| container_issue | 3 |
| container_start_page | 256 |
| container_title | European journal of radiology |
| container_volume | 43 |
| creator | Ghanem, Nadir Altehoefer, Carsten Högerle, Stefan Schäfer, Oliver Winterer, Jan Moser, Ernst Langer, Mathias |
| description | Purpose: To evaluate the comparative impact of magnetic resonance imaging (MRI) and bone marrow scintigraphy (BMS) in bone marrow metastases of solid tumors.
Methods: In 20 patients with solid tumors MRI of the axial skeleton and whole-body BMS were retrospectively reviewed. Detectability of metastases, extent of disease and therapeutic implications were assessed.
Results: In 15/20 (75%) patients MRI and BMS concordantly revealed bone marrow metastases of the axial skeleton. In nine of these 15 patients (60%) MRI showed more metastases. Local radiotherapy or surgery was performed in seven of these cases (78%). BMS detected additional metastases of the appendicular skeleton in 8/15 (53%) patients. In 4/20 cases (20%) the imaging findings were discordant. In three patients with degenerative changes (
n=2) or lipoma (
n=1) BMS was false positive. In another patient BMS failed to detect metastases proven by MRI and clinical follow-up resulting in subsequent radiation therapy. One patient had normal bone marrow.
Conclusion: MRI appears to be more sensitive and specific in the detection of bone marrow metastases in the axial skeleton and is of clinical importance for subsequent local therapy. |
| doi_str_mv | 10.1016/S0720-048X(01)00477-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72051023</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0720048X01004776</els_id><sourcerecordid>72051023</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-f31baa768d17be408eea2029eb5740f60a411d0b0b88c605dda01149a51da6823</originalsourceid><addsrcrecordid>eNqFkc2O1DAQhC0EYoeFRwD5AoJDoO38n1ZoxJ-0EgdA4mZ14s6MIbGD7cyyb8Uj4syM2CMnS6Wvu9xVjD0V8FqAqN58gVpCBkXz_SWIVwBFXWfVPbYRTS2zupb1fbb5h1ywRyH8AICyaOVDdiGkhKKAZsP-bN00o8doDsS1wZ11IZqeH3BciKPVPO7J40zLqnoa6YC2J-4GPiWYTmpw9qiapBm7O851zlJivHc3PPTGRrNLe_a33Fg-Jz-yMfAbE_d8oogh4roquNEky2VyPqweyZzjb4MjDz-Td3T2MXsw4Bjoyfm9ZN_ev_u6_Zhdf_7wafv2OuvzVsRsyEWHWFeNFnVH6VQilCBb6sq6gKECLITQ0EHXNH0FpdYIQhQtlkJj1cj8kr047Z29-7VQiGoyoadxREtuCSpFWwqQeQLLE9h7F4KnQc0-5eBvlQC1VqWOVam1BwVCHatSVZp7djZYuon03dS5mwQ8PwMYehwHnyI24Y7LWymlKBN3deIoxXEw5FWKm1Id2njqo9LO_OcrfwEhyrV6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72051023</pqid></control><display><type>article</type><title>Comparative diagnostic value and therapeutic relevance of magnetic resonance imaging and bone marrow scintigraphy in patients with metastatic solid tumors of the axial skeleton</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Ghanem, Nadir ; Altehoefer, Carsten ; Högerle, Stefan ; Schäfer, Oliver ; Winterer, Jan ; Moser, Ernst ; Langer, Mathias</creator><creatorcontrib>Ghanem, Nadir ; Altehoefer, Carsten ; Högerle, Stefan ; Schäfer, Oliver ; Winterer, Jan ; Moser, Ernst ; Langer, Mathias</creatorcontrib><description>Purpose: To evaluate the comparative impact of magnetic resonance imaging (MRI) and bone marrow scintigraphy (BMS) in bone marrow metastases of solid tumors.
Methods: In 20 patients with solid tumors MRI of the axial skeleton and whole-body BMS were retrospectively reviewed. Detectability of metastases, extent of disease and therapeutic implications were assessed.
Results: In 15/20 (75%) patients MRI and BMS concordantly revealed bone marrow metastases of the axial skeleton. In nine of these 15 patients (60%) MRI showed more metastases. Local radiotherapy or surgery was performed in seven of these cases (78%). BMS detected additional metastases of the appendicular skeleton in 8/15 (53%) patients. In 4/20 cases (20%) the imaging findings were discordant. In three patients with degenerative changes (
n=2) or lipoma (
n=1) BMS was false positive. In another patient BMS failed to detect metastases proven by MRI and clinical follow-up resulting in subsequent radiation therapy. One patient had normal bone marrow.
Conclusion: MRI appears to be more sensitive and specific in the detection of bone marrow metastases in the axial skeleton and is of clinical importance for subsequent local therapy.</description><identifier>ISSN: 0720-048X</identifier><identifier>EISSN: 1872-7727</identifier><identifier>DOI: 10.1016/S0720-048X(01)00477-6</identifier><identifier>PMID: 12204408</identifier><identifier>CODEN: EJRADR</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Biological and medical sciences ; Bone marrow metastases ; Bone Marrow Neoplasms - diagnostic imaging ; Bone Marrow Neoplasms - secondary ; Bone Marrow Neoplasms - therapy ; Bone marrow scintigraphy ; Bone Neoplasms - diagnostic imaging ; Bone Neoplasms - secondary ; Bone Neoplasms - therapy ; Breast Neoplasms - pathology ; Diagnostic value ; Diseases of the osteoarticular system ; Female ; Humans ; Lung Neoplasms - pathology ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Predictive Value of Tests ; Prognosis ; Radiography ; Radionuclide Imaging ; Retrospective Studies ; Risk Factors ; Sensitivity and Specificity ; Solid tumor ; Tumors of striated muscle and skeleton ; Urinary Bladder Neoplasms - pathology</subject><ispartof>European journal of radiology, 2002-09, Vol.43 (3), p.256-261</ispartof><rights>2002 Elsevier Science Ireland Ltd</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-f31baa768d17be408eea2029eb5740f60a411d0b0b88c605dda01149a51da6823</citedby><cites>FETCH-LOGICAL-c391t-f31baa768d17be408eea2029eb5740f60a411d0b0b88c605dda01149a51da6823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0720048X01004776$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13922215$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12204408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghanem, Nadir</creatorcontrib><creatorcontrib>Altehoefer, Carsten</creatorcontrib><creatorcontrib>Högerle, Stefan</creatorcontrib><creatorcontrib>Schäfer, Oliver</creatorcontrib><creatorcontrib>Winterer, Jan</creatorcontrib><creatorcontrib>Moser, Ernst</creatorcontrib><creatorcontrib>Langer, Mathias</creatorcontrib><title>Comparative diagnostic value and therapeutic relevance of magnetic resonance imaging and bone marrow scintigraphy in patients with metastatic solid tumors of the axial skeleton</title><title>European journal of radiology</title><addtitle>Eur J Radiol</addtitle><description>Purpose: To evaluate the comparative impact of magnetic resonance imaging (MRI) and bone marrow scintigraphy (BMS) in bone marrow metastases of solid tumors.
Methods: In 20 patients with solid tumors MRI of the axial skeleton and whole-body BMS were retrospectively reviewed. Detectability of metastases, extent of disease and therapeutic implications were assessed.
Results: In 15/20 (75%) patients MRI and BMS concordantly revealed bone marrow metastases of the axial skeleton. In nine of these 15 patients (60%) MRI showed more metastases. Local radiotherapy or surgery was performed in seven of these cases (78%). BMS detected additional metastases of the appendicular skeleton in 8/15 (53%) patients. In 4/20 cases (20%) the imaging findings were discordant. In three patients with degenerative changes (
n=2) or lipoma (
n=1) BMS was false positive. In another patient BMS failed to detect metastases proven by MRI and clinical follow-up resulting in subsequent radiation therapy. One patient had normal bone marrow.
Conclusion: MRI appears to be more sensitive and specific in the detection of bone marrow metastases in the axial skeleton and is of clinical importance for subsequent local therapy.</description><subject>Biological and medical sciences</subject><subject>Bone marrow metastases</subject><subject>Bone Marrow Neoplasms - diagnostic imaging</subject><subject>Bone Marrow Neoplasms - secondary</subject><subject>Bone Marrow Neoplasms - therapy</subject><subject>Bone marrow scintigraphy</subject><subject>Bone Neoplasms - diagnostic imaging</subject><subject>Bone Neoplasms - secondary</subject><subject>Bone Neoplasms - therapy</subject><subject>Breast Neoplasms - pathology</subject><subject>Diagnostic value</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Radiography</subject><subject>Radionuclide Imaging</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>Solid tumor</subject><subject>Tumors of striated muscle and skeleton</subject><subject>Urinary Bladder Neoplasms - pathology</subject><issn>0720-048X</issn><issn>1872-7727</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2O1DAQhC0EYoeFRwD5AoJDoO38n1ZoxJ-0EgdA4mZ14s6MIbGD7cyyb8Uj4syM2CMnS6Wvu9xVjD0V8FqAqN58gVpCBkXz_SWIVwBFXWfVPbYRTS2zupb1fbb5h1ywRyH8AICyaOVDdiGkhKKAZsP-bN00o8doDsS1wZ11IZqeH3BciKPVPO7J40zLqnoa6YC2J-4GPiWYTmpw9qiapBm7O851zlJivHc3PPTGRrNLe_a33Fg-Jz-yMfAbE_d8oogh4roquNEky2VyPqweyZzjb4MjDz-Td3T2MXsw4Bjoyfm9ZN_ev_u6_Zhdf_7wafv2OuvzVsRsyEWHWFeNFnVH6VQilCBb6sq6gKECLITQ0EHXNH0FpdYIQhQtlkJj1cj8kr047Z29-7VQiGoyoadxREtuCSpFWwqQeQLLE9h7F4KnQc0-5eBvlQC1VqWOVam1BwVCHatSVZp7djZYuon03dS5mwQ8PwMYehwHnyI24Y7LWymlKBN3deIoxXEw5FWKm1Id2njqo9LO_OcrfwEhyrV6</recordid><startdate>20020901</startdate><enddate>20020901</enddate><creator>Ghanem, Nadir</creator><creator>Altehoefer, Carsten</creator><creator>Högerle, Stefan</creator><creator>Schäfer, Oliver</creator><creator>Winterer, Jan</creator><creator>Moser, Ernst</creator><creator>Langer, Mathias</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020901</creationdate><title>Comparative diagnostic value and therapeutic relevance of magnetic resonance imaging and bone marrow scintigraphy in patients with metastatic solid tumors of the axial skeleton</title><author>Ghanem, Nadir ; Altehoefer, Carsten ; Högerle, Stefan ; Schäfer, Oliver ; Winterer, Jan ; Moser, Ernst ; Langer, Mathias</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-f31baa768d17be408eea2029eb5740f60a411d0b0b88c605dda01149a51da6823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Biological and medical sciences</topic><topic>Bone marrow metastases</topic><topic>Bone Marrow Neoplasms - diagnostic imaging</topic><topic>Bone Marrow Neoplasms - secondary</topic><topic>Bone Marrow Neoplasms - therapy</topic><topic>Bone marrow scintigraphy</topic><topic>Bone Neoplasms - diagnostic imaging</topic><topic>Bone Neoplasms - secondary</topic><topic>Bone Neoplasms - therapy</topic><topic>Breast Neoplasms - pathology</topic><topic>Diagnostic value</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Radiography</topic><topic>Radionuclide Imaging</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><topic>Solid tumor</topic><topic>Tumors of striated muscle and skeleton</topic><topic>Urinary Bladder Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghanem, Nadir</creatorcontrib><creatorcontrib>Altehoefer, Carsten</creatorcontrib><creatorcontrib>Högerle, Stefan</creatorcontrib><creatorcontrib>Schäfer, Oliver</creatorcontrib><creatorcontrib>Winterer, Jan</creatorcontrib><creatorcontrib>Moser, Ernst</creatorcontrib><creatorcontrib>Langer, Mathias</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghanem, Nadir</au><au>Altehoefer, Carsten</au><au>Högerle, Stefan</au><au>Schäfer, Oliver</au><au>Winterer, Jan</au><au>Moser, Ernst</au><au>Langer, Mathias</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative diagnostic value and therapeutic relevance of magnetic resonance imaging and bone marrow scintigraphy in patients with metastatic solid tumors of the axial skeleton</atitle><jtitle>European journal of radiology</jtitle><addtitle>Eur J Radiol</addtitle><date>2002-09-01</date><risdate>2002</risdate><volume>43</volume><issue>3</issue><spage>256</spage><epage>261</epage><pages>256-261</pages><issn>0720-048X</issn><eissn>1872-7727</eissn><coden>EJRADR</coden><abstract>Purpose: To evaluate the comparative impact of magnetic resonance imaging (MRI) and bone marrow scintigraphy (BMS) in bone marrow metastases of solid tumors.
Methods: In 20 patients with solid tumors MRI of the axial skeleton and whole-body BMS were retrospectively reviewed. Detectability of metastases, extent of disease and therapeutic implications were assessed.
Results: In 15/20 (75%) patients MRI and BMS concordantly revealed bone marrow metastases of the axial skeleton. In nine of these 15 patients (60%) MRI showed more metastases. Local radiotherapy or surgery was performed in seven of these cases (78%). BMS detected additional metastases of the appendicular skeleton in 8/15 (53%) patients. In 4/20 cases (20%) the imaging findings were discordant. In three patients with degenerative changes (
n=2) or lipoma (
n=1) BMS was false positive. In another patient BMS failed to detect metastases proven by MRI and clinical follow-up resulting in subsequent radiation therapy. One patient had normal bone marrow.
Conclusion: MRI appears to be more sensitive and specific in the detection of bone marrow metastases in the axial skeleton and is of clinical importance for subsequent local therapy.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>12204408</pmid><doi>10.1016/S0720-048X(01)00477-6</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0720-048X |
| ispartof | European journal of radiology, 2002-09, Vol.43 (3), p.256-261 |
| issn | 0720-048X 1872-7727 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72051023 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Bone marrow metastases Bone Marrow Neoplasms - diagnostic imaging Bone Marrow Neoplasms - secondary Bone Marrow Neoplasms - therapy Bone marrow scintigraphy Bone Neoplasms - diagnostic imaging Bone Neoplasms - secondary Bone Neoplasms - therapy Breast Neoplasms - pathology Diagnostic value Diseases of the osteoarticular system Female Humans Lung Neoplasms - pathology Magnetic Resonance Imaging Male Medical sciences Predictive Value of Tests Prognosis Radiography Radionuclide Imaging Retrospective Studies Risk Factors Sensitivity and Specificity Solid tumor Tumors of striated muscle and skeleton Urinary Bladder Neoplasms - pathology |
| title | Comparative diagnostic value and therapeutic relevance of magnetic resonance imaging and bone marrow scintigraphy in patients with metastatic solid tumors of the axial skeleton |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T07%3A25%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparative%20diagnostic%20value%20and%20therapeutic%20relevance%20of%20magnetic%20resonance%20imaging%20and%20bone%20marrow%20scintigraphy%20in%20patients%20with%20metastatic%20solid%20tumors%20of%20the%20axial%20skeleton&rft.jtitle=European%20journal%20of%20radiology&rft.au=Ghanem,%20Nadir&rft.date=2002-09-01&rft.volume=43&rft.issue=3&rft.spage=256&rft.epage=261&rft.pages=256-261&rft.issn=0720-048X&rft.eissn=1872-7727&rft.coden=EJRADR&rft_id=info:doi/10.1016/S0720-048X(01)00477-6&rft_dat=%3Cproquest_cross%3E72051023%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72051023&rft_id=info:pmid/12204408&rft_els_id=S0720048X01004776&rfr_iscdi=true |