Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries
In this study, 12 new 2,2,7,7-tetramethyl-9-aryl-2,3,4,5,6,7,9,10-octahydro-1,8-acridindione derivatives were synthesised and their effects on vascular potassium channels and mechanism of induced relaxations on phenylephrine-induced contractile responses in isolated rabbit thoracic arteries was inve...
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| Veröffentlicht in: | European journal of medicinal chemistry 2002-06, Vol.37 (6), p.519-523 |
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| container_title | European journal of medicinal chemistry |
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| creator | BERKAN, Öcal SARAC, Bülent SIMSEK, Rahime YILDIRIM, Sahin SARIOGLU, Yusuf SAFAK, Cihat |
| description | In this study, 12 new 2,2,7,7-tetramethyl-9-aryl-2,3,4,5,6,7,9,10-octahydro-1,8-acridindione derivatives were synthesised and their effects on vascular potassium channels and mechanism of induced relaxations on phenylephrine-induced contractile responses in isolated rabbit thoracic arteries was investigated. Pinacidil was used as standard potassium channel openers in this study. Compounds
1–
12 and pinacidil exerted concentration-dependent relaxation responses precontracted phenylephrine in the aortic rings with the efficacy order:
11>pinacidil>
7>
2>
8>
3>
1>
4>
10>
6>
9>
5>
12. |
| doi_str_mv | 10.1016/S0223-5234(02)01374-0 |
| format | Article |
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1–
12 and pinacidil exerted concentration-dependent relaxation responses precontracted phenylephrine in the aortic rings with the efficacy order:
11>pinacidil>
7>
2>
8>
3>
1>
4>
10>
6>
9>
5>
12.</description><identifier>ISSN: 0223-5234</identifier><identifier>EISSN: 1768-3254</identifier><identifier>DOI: 10.1016/S0223-5234(02)01374-0</identifier><identifier>PMID: 12204478</identifier><identifier>CODEN: EJMCA5</identifier><language>eng</language><publisher>Oxford: Elsevier Masson SAS</publisher><subject>Acridindione ; Acridines - chemical synthesis ; Acridines - pharmacology ; Animals ; Aorta, Thoracic - drug effects ; Biological and medical sciences ; Cardiovascular system ; Glyburide - pharmacology ; Hypoglycemic Agents - pharmacology ; In Vitro Techniques ; Kinetics ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; Molecular Weight ; Muscle, Smooth, Vascular - drug effects ; Pharmacology. Drug treatments ; Phenylephrine - antagonists & inhibitors ; Pinacidil - pharmacology ; Potassium channel openers ; Potassium Channels - agonists ; Rabbits ; Synthesis ; Tetraethylammonium Compounds - pharmacology ; Vasoconstrictor Agents - antagonists & inhibitors ; Vasodilator Agents - chemical synthesis ; Vasodilator Agents - pharmacology ; Vasodilator agents. Cerebral vasodilators</subject><ispartof>European journal of medicinal chemistry, 2002-06, Vol.37 (6), p.519-523</ispartof><rights>2002</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-512fc0e814e8dd623dad6ec6b5d14dd96b2c080c477124c35172677d1d5d1c93</citedby><cites>FETCH-LOGICAL-c391t-512fc0e814e8dd623dad6ec6b5d14dd96b2c080c477124c35172677d1d5d1c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0223523402013740$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13755882$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12204478$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BERKAN, Öcal</creatorcontrib><creatorcontrib>SARAC, Bülent</creatorcontrib><creatorcontrib>SIMSEK, Rahime</creatorcontrib><creatorcontrib>YILDIRIM, Sahin</creatorcontrib><creatorcontrib>SARIOGLU, Yusuf</creatorcontrib><creatorcontrib>SAFAK, Cihat</creatorcontrib><title>Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries</title><title>European journal of medicinal chemistry</title><addtitle>Eur J Med Chem</addtitle><description>In this study, 12 new 2,2,7,7-tetramethyl-9-aryl-2,3,4,5,6,7,9,10-octahydro-1,8-acridindione derivatives were synthesised and their effects on vascular potassium channels and mechanism of induced relaxations on phenylephrine-induced contractile responses in isolated rabbit thoracic arteries was investigated. Pinacidil was used as standard potassium channel openers in this study. Compounds
1–
12 and pinacidil exerted concentration-dependent relaxation responses precontracted phenylephrine in the aortic rings with the efficacy order:
11>pinacidil>
7>
2>
8>
3>
1>
4>
10>
6>
9>
5>
12.</description><subject>Acridindione</subject><subject>Acridines - chemical synthesis</subject><subject>Acridines - pharmacology</subject><subject>Animals</subject><subject>Aorta, Thoracic - drug effects</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Glyburide - pharmacology</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Kinetics</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Weight</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenylephrine - antagonists & inhibitors</subject><subject>Pinacidil - pharmacology</subject><subject>Potassium channel openers</subject><subject>Potassium Channels - agonists</subject><subject>Rabbits</subject><subject>Synthesis</subject><subject>Tetraethylammonium Compounds - pharmacology</subject><subject>Vasoconstrictor Agents - antagonists & inhibitors</subject><subject>Vasodilator Agents - chemical synthesis</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Vasodilator agents. Cerebral vasodilators</subject><issn>0223-5234</issn><issn>1768-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEuLFDEURoMoTs_oT1CyUcZF6c2rUr0aZPAFAy4c3IZUcsuOVCVlkhb735uZbpylqwuX893HIeQFg7cMWP_uG3AuOsWFvAT-BpjQsoNHZMN0P3SCK_mYbP4hZ-S8lJ8AoHqAp-SMcQ5S6mFD8ndbUsbZ_gnxB11zWjHXgIWmiZa0IF13GA-zdTn4EJHWw9p6qdpSwn6hbmdjxJm2WMRcaIg0lDTbip5mO46h0rpL2brgqM0Vcxv9jDyZ7Fzw-alekNuPH26vP3c3Xz99uX5_0zmxZbVTjE8OcGASB-97Lrz1Pbp-VJ5J77f9yB0M4KTWjEsnFNO819oz3wC3FRfk9XFse-rXHks1SygO59lGTPtiNAcFWzk0UB1Bl1MpGSez5rDYfDAMzJ1rc-_a3Ik0wM29awMt9_K0YD8u6B9SJ7kNeHUCbHF2nrKNLpQHTmilhoE37urIYbPxO2A2xQWMDn3I6KrxKfznlL8vRp2F</recordid><startdate>20020601</startdate><enddate>20020601</enddate><creator>BERKAN, Öcal</creator><creator>SARAC, Bülent</creator><creator>SIMSEK, Rahime</creator><creator>YILDIRIM, Sahin</creator><creator>SARIOGLU, Yusuf</creator><creator>SAFAK, Cihat</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020601</creationdate><title>Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries</title><author>BERKAN, Öcal ; SARAC, Bülent ; SIMSEK, Rahime ; YILDIRIM, Sahin ; SARIOGLU, Yusuf ; SAFAK, Cihat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-512fc0e814e8dd623dad6ec6b5d14dd96b2c080c477124c35172677d1d5d1c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acridindione</topic><topic>Acridines - chemical synthesis</topic><topic>Acridines - pharmacology</topic><topic>Animals</topic><topic>Aorta, Thoracic - drug effects</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Glyburide - pharmacology</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Kinetics</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular Weight</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenylephrine - antagonists & inhibitors</topic><topic>Pinacidil - pharmacology</topic><topic>Potassium channel openers</topic><topic>Potassium Channels - agonists</topic><topic>Rabbits</topic><topic>Synthesis</topic><topic>Tetraethylammonium Compounds - pharmacology</topic><topic>Vasoconstrictor Agents - antagonists & inhibitors</topic><topic>Vasodilator Agents - chemical synthesis</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Vasodilator agents. Cerebral vasodilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BERKAN, Öcal</creatorcontrib><creatorcontrib>SARAC, Bülent</creatorcontrib><creatorcontrib>SIMSEK, Rahime</creatorcontrib><creatorcontrib>YILDIRIM, Sahin</creatorcontrib><creatorcontrib>SARIOGLU, Yusuf</creatorcontrib><creatorcontrib>SAFAK, Cihat</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BERKAN, Öcal</au><au>SARAC, Bülent</au><au>SIMSEK, Rahime</au><au>YILDIRIM, Sahin</au><au>SARIOGLU, Yusuf</au><au>SAFAK, Cihat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries</atitle><jtitle>European journal of medicinal chemistry</jtitle><addtitle>Eur J Med Chem</addtitle><date>2002-06-01</date><risdate>2002</risdate><volume>37</volume><issue>6</issue><spage>519</spage><epage>523</epage><pages>519-523</pages><issn>0223-5234</issn><eissn>1768-3254</eissn><coden>EJMCA5</coden><abstract>In this study, 12 new 2,2,7,7-tetramethyl-9-aryl-2,3,4,5,6,7,9,10-octahydro-1,8-acridindione derivatives were synthesised and their effects on vascular potassium channels and mechanism of induced relaxations on phenylephrine-induced contractile responses in isolated rabbit thoracic arteries was investigated. Pinacidil was used as standard potassium channel openers in this study. Compounds
1–
12 and pinacidil exerted concentration-dependent relaxation responses precontracted phenylephrine in the aortic rings with the efficacy order:
11>pinacidil>
7>
2>
8>
3>
1>
4>
10>
6>
9>
5>
12.</abstract><cop>Oxford</cop><pub>Elsevier Masson SAS</pub><pmid>12204478</pmid><doi>10.1016/S0223-5234(02)01374-0</doi><tpages>5</tpages></addata></record> |
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| subjects | Acridindione Acridines - chemical synthesis Acridines - pharmacology Animals Aorta, Thoracic - drug effects Biological and medical sciences Cardiovascular system Glyburide - pharmacology Hypoglycemic Agents - pharmacology In Vitro Techniques Kinetics Magnetic Resonance Spectroscopy Male Medical sciences Molecular Weight Muscle, Smooth, Vascular - drug effects Pharmacology. Drug treatments Phenylephrine - antagonists & inhibitors Pinacidil - pharmacology Potassium channel openers Potassium Channels - agonists Rabbits Synthesis Tetraethylammonium Compounds - pharmacology Vasoconstrictor Agents - antagonists & inhibitors Vasodilator Agents - chemical synthesis Vasodilator Agents - pharmacology Vasodilator agents. Cerebral vasodilators |
| title | Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries |
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